{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:18:48Z","timestamp":1787649528083,"version":"build-2736575974"},"reference-count":75,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: Substance use disorders (SUDs) remain a major public health challenge, with high relapse rates despite established pharmacological and behavioral treatments. This scoping review maps evidence on structured exercise interventions as therapeutic approaches in SUD treatment, focusing on direct clinical outcomes, substance-specific effects, and implementation strategies. Methods: Following PRISMA-ScR and JBI guidance, searches of PubMed, Scopus, PsycINFO, and SPORTDiscus identified human studies published from 2000 to 31 December 2024 that evaluated supervised exercise interventions in adults with SUDs. Results: Evidence from randomized trials and recent network meta-analyses indicates clinically relevant benefits for abstinence, craving reduction, mood symptoms, cognitive function, treatment retention, and withdrawal management. Moderate-to-vigorous aerobic exercise delivered three to four times weekly for at least 12 weeks, at approximately 180 MET-minutes per week, appears particularly effective, while combined aerobic and muscle-performance protocols may yield broader benefits. Conclusions: Exercise interventions show strong potential as adjuncts to SUD care. Implementation should incorporate individualized prescription, substance-specific safety screening, cardiovascular and psychiatric monitoring, and multidisciplinary coordination. Further long-term randomized trials, mechanistic studies, and cost-effectiveness evaluations are needed.<\/jats:p>","DOI":"10.3390\/diseases14080272","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exercise Training Interventions as Therapeutic Approaches in Substance Use Disorder Treatment: A Scoping Review of Direct Clinical Outcomes and Implementation Strategies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-7678","authenticated-orcid":false,"given":"Karim","family":"Chamari","sequence":"first","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-546X","authenticated-orcid":false,"given":"Wissem","family":"Dhahbi","sequence":"additional","affiliation":[{"name":"Research Unit \u201cSport Sciences, Health and Movement\u201d, High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef 8100, Tunisia"},{"name":"Training Department, Police College, Qatar Police Academy, Doha P.O. Box 7157, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaia","family":"AlMadhoun","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4729-0526","authenticated-orcid":false,"given":"James","family":"England","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mansi","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala Al","family":"Ali","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jallal","family":"Toufiq","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. Box 93097, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9827-7881","authenticated-orcid":false,"given":"Khalifa","family":"Alkuwari","sequence":"additional","affiliation":[{"name":"Naufar Centre, Doha P.O. 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Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/psyrad\/kkac021","article-title":"Neurobiological mechanisms and related clinical treatment of addiction: A review","volume":"2","author":"Fang","year":"2022","journal-title":"Psychoradiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100519","DOI":"10.1016\/j.mhpa.2023.100519","article-title":"Evidence level of physical exercise in the treatment of substance abuse\/dependence: An overview of systematic reviews including 53 meta-analyses that comprised 103 distinct clinical trials","volume":"24","year":"2023","journal-title":"Ment. Health Phys. Act."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, T., Chen, Z., and Gao, K. (2025). Effects of physical exercise interventions on multidimensional health outcomes in patients with substance use disorders: A network meta-analysis. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1732663"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13722-025-00639-x","article-title":"Effects of different exercise types on craving in substance use disorder patients with drug dependence -network meta-analysis and dose-response relationships based on frequentist and Bayesian models","volume":"21","author":"Wang","year":"2025","journal-title":"Addict. Sci. Clin. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mahalakshmi, B., Maurya, N., Lee, S.D., and Kumar, V.B. (2020). Possible neuroprotective mechanisms of physical exercise in neurodegeneration. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165895"},{"key":"ref_9","first-page":"151","article-title":"Evaluation of the effects of high intensity interval training on cytokine levels and clinical course in treatment of opioid use disorder","volume":"31","author":"Durmus","year":"2020","journal-title":"Turk. J. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/bs.irn.2019.07.007","article-title":"Exercise and substance abuse","volume":"147","author":"Zhang","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.35946\/arcr.v34.4.11","article-title":"Stress and the HPA axis: Role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens","year":"2012","journal-title":"Alcohol Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Psarianos, A., Chryssanthopoulos, C., Paparrigopoulos, T.J., and Philippou, A. (2023). The Role of Physical Exercise in Opioid Substitution Therapy: Mechanisms of Sequential Effects. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054763"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mont\u00f3n-Mart\u00ednez, R., Castellano-Galva\u00f1, I., Rold\u00e1n, A., Javaloyes, A., Pe\u00f1a-Gonz\u00e1lez, I., Sarabia, J.M., and Moya-Ram\u00f3n, M. (2025). Effects of physical exercise on substance use disorder: A comprehensive review. Appl. Sci., 15.","DOI":"10.3390\/app15031481"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chmiel, J., Malinowska, A., Rybakowski, F., and Leszek, J. (2024). The Effectiveness of Mindfulness in the Treatment of Methamphetamine Addiction Symptoms: Does Neuroplasticity Play a Role?. Brain Sci., 14.","DOI":"10.3390\/brainsci14040320"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/00952990.2016.1185434","article-title":"Exercise as an adjunctive treatment for cannabis use disorder","volume":"42","author":"Brellenthin","year":"2016","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Vieira, W.F., Real, C.C., Martins, D.O., and Chacur, M. (2025). The Role of Exercise on Glial Cell Activity in Neuropathic Pain Management. Cells, 14.","DOI":"10.3390\/cells14070487"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"616935","DOI":"10.1155\/2014\/616935","article-title":"High-Intensity Interval Training in Patients with Substance Use Disorder","volume":"2014","author":"Flemmen","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Andreassen, \u00d8., Br\u00f8nnick, K.K., Nj\u00e5, A.-L.M., Furulund, E., and Nesv\u00e5g, S. (2019). The Effect of High-Intensity Interval\/Circuit Training on Cognitive Functioning and Quality of Life During Recovery From Substance Abuse Disorder. A Study Protocol. Front. Psychol., 10.","DOI":"10.3389\/fpsyg.2019.02564"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Haberstroh, C., Weider, S., Flemmen, G., Loe, H., Andersson, H.W., Hallgren, M., and Mosti, M.P. (2022). The effect of high-intensity interval training on cognitive function in patients with substance use disorder: Study protocol for a two-armed randomized controlled trial. Front. Sports Act. Living, 4.","DOI":"10.3389\/fspor.2022.954561"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Theodorakis, Y., Hassandra, M., and Panagiotounis, F. (2024). Enhancing Substance Use Disorder Recovery through Integrated Physical Activity and Behavioral Interventions: A Comprehensive Approach to Treatment and Prevention. Brain Sci., 14.","DOI":"10.3390\/brainsci14060534"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Publishing.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_22","unstructured":"Aromataris, E., and Munn, Z. (2020). JBI Manual for Evidence Synthesis, JBI."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_24","first-page":"520","article-title":"Recommendations for the extraction, analysis, and presentation of results in scoping reviews","volume":"19","author":"Pollock","year":"2021","journal-title":"JBI Evid. Synth."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jsat.2017.01.012","article-title":"A pilot randomized trial of exercise as adjunct therapy in a heroin-assisted treatment setting","volume":"76","author":"Colledge","year":"2017","journal-title":"J. Subst. Abus. Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100360","DOI":"10.1016\/j.mhpa.2020.100360","article-title":"Physical activity and the prevention, reduction, and treatment of alcohol and other drug use across the lifespan (the PHASE review): A systematic review","volume":"19","author":"Thompson","year":"2020","journal-title":"Ment. Health Phys. Act."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Munn, Z., Peters, M.D.J., Stern, C., Tufanaru, C., McArthur, A., and Aromataris, E. (2020). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med. Res. Methodol., 18.","DOI":"10.1186\/s12874-018-0611-x"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.5114\/biolsport.2023.125623","article-title":"From human writing to artificial intelligence generated text: Examining the prospects and potential threats of ChatGPT in academic writing","volume":"40","author":"Dergaa","year":"2023","journal-title":"Biol. Sport"},{"key":"ref_30","first-page":"1353","article-title":"Toward autonomous artificial intelligence agents in sports science: A modular framework for development, validation, and implementation","volume":"43","author":"Dergaa","year":"2026","journal-title":"Biol. Sport"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wang, D., Wang, Y., Wang, Y., Li, R., and Zhou, C. (2014). Impact of physical exercise on substance use disorders: A meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110728"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/psb.1841","article-title":"Role of exercise in managing substance use disorders","volume":"31","author":"Cabrera","year":"2020","journal-title":"Prescriber"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2478\/bhk-2022-0015","article-title":"Effects of exercise training on depression and anxiety with changing neurotransmitters in methamphetamine long term abusers: A narrative review","volume":"14","author":"Arazi","year":"2022","journal-title":"Biomed. Hum. Kinet."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Zhao, Y., Chen, X., and Li, S. (2024). Effect of physical exercise on the emotional and cognitive levels of patients with substance use disorder: A meta-analysis. Front. Psychol., 15.","DOI":"10.3389\/fpsyg.2024.1348224"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e061014","DOI":"10.1136\/bmjopen-2022-061014","article-title":"Cardiopulmonary and muscular effects of different doses of high-intensity physical training in substance use disorder patients: Study protocol for a block allocated controlled endurance and strength training trial in an inpatient setting","volume":"12","author":"Loe","year":"2022","journal-title":"BMJ Open"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pich\u00e9, F., Daneau, C., Plourde, C., Girard, S., and Romain, A.J. (2023). Characteristics and impact of physical activity interventions during substance use disorder treatment excluding tobacco: A systematic review. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0283861"},{"key":"ref_37","unstructured":"American College of Sports Medicine (2021). ACSM\u2019s Guidelines for Exercise Testing and Prescription, Wolters Kluwer."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.addbeh.2008.03.011","article-title":"Exercise-related activities are associated with positive outcome in contingency management treatment for substance use disorders","volume":"33","author":"Weinstock","year":"2008","journal-title":"Addict. Behav."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhang, Z., and Liu, X. (2022). A systematic review of exercise intervention program for people with substance use disorder. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.817927"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Unhjem, R., Flemmen, G., Hoff, J., and Wang, E. (2016). Maximal strength training as physical rehabilitation for patients with substance use disorder; a randomized controlled trial. BMC Sports Sci. Med. Rehabil., 8.","DOI":"10.1186\/s13102-016-0032-2"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Colledge, F., Gerber, M., P\u00fchse, U., and Ludyga, S. (2018). Anaerobic exercise training in the therapy of substance use disorders: A systematic review. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00644"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109247","DOI":"10.1016\/j.drugalcdep.2021.109247","article-title":"Craving among individuals with stimulant use disorder in residential social model-based treatment\u2014Can exercise help?","volume":"231","author":"Salem","year":"2022","journal-title":"Drug Alcohol Depend."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.drugalcdep.2015.08.029","article-title":"Impact of an exercise intervention on methamphetamine use outcomes post-residential treatment care","volume":"156","author":"Rawson","year":"2015","journal-title":"Drug Alcohol Depend."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/ADM.0b013e318282475e","article-title":"Eight weeks of exercise training improves fitness measures in methamphetamine-dependent individuals in residential treatment","volume":"7","author":"Dolezal","year":"2013","journal-title":"J. Addict. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, H., Su, W., Cai, J., Zhao, L., and Li, Y. (2023). Effects of exercise of different intensities on withdrawal symptoms among people with substance use disorder: A systematic review and meta-analysis. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1126777"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/ajad.12175","article-title":"Predictors of depression outcomes among abstinent methamphetamine-dependent individuals exposed to an exercise intervention","volume":"24","author":"Haglund","year":"2015","journal-title":"Am. J. Addict."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1519\/JSC.0b013e31816a4419","article-title":"Effect of concurrent endurance and circuit resistance training sequence on muscular strength and power development","volume":"22","author":"Chtara","year":"2008","journal-title":"J. Strength Cond. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/bjsm.2004.015248","article-title":"Effects of intra-session concurrent endurance and strength training sequence on aerobic performance and capacity","volume":"39","author":"Chtara","year":"2005","journal-title":"Br. J. Sports Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/17461391.2010.509889","article-title":"Changes in mental distress following individualized physical training in patients suffering from chemical dependence","volume":"11","author":"Mamen","year":"2011","journal-title":"Eur. J. Sport Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Xu, C., Zhang, Z., Hou, D., Wang, G., Li, C., Ma, X., Wang, K., Luo, H., and Zhu, M. (2024). Effects of exercise interventions on negative emotions, cognitive performance and drug craving in methamphetamine addiction. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1402533"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e41018","DOI":"10.1097\/MD.0000000000041018","article-title":"Exploring exercise interventions in substance abuse treatment: A comprehensive bibliometric analysis","volume":"103","author":"Chen","year":"2024","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.4088\/JCP.15m10591","article-title":"Randomized controlled trial comparing exercise to health education for stimulant use disorder: Results from STimulant Reduction Intervention using Dosed Exercise study","volume":"78","author":"Trivedi","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cui, J., Liu, F., Liu, X., Li, R., Chen, X., and Zeng, H. (2022). The impact of qigong and tai chi exercise on drug addiction: A systematic review and meta-analysis. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.826187"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/bjsports-2016-096814","article-title":"Exercise as treatment for alcohol use disorders: Systematic review and meta-analysis","volume":"51","author":"Hallgren","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/NNR.0b013e318292379b","article-title":"Yoga effects on mood and quality of life in Chinese women undergoing heroin detoxification: A randomized controlled trial","volume":"62","author":"Zhuang","year":"2013","journal-title":"Nurs. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1590\/0047-2085000000416","article-title":"Combined physical training associated with multidisciplinary intervention in the treatment of alcohol use disorder: A study with n of 1","volume":"72","author":"Pires","year":"2023","journal-title":"J. Bras. Psiquiatr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13063-024-07993-2","article-title":"Integrated exercise program in opioid agonist therapy clinics and effect on psychological distress: Study protocol for a randomized controlled trial (BAReAktiv)","volume":"25","author":"Furulund","year":"2024","journal-title":"Trials"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100421","DOI":"10.1016\/j.mhpa.2021.100421","article-title":"Moderators of treatment response to exercise in participants with stimulant use disorder: Exploratory results from the stimulant reduction using dosed exercise (STRIDE) CTN-0037 study","volume":"21","author":"Rethorst","year":"2021","journal-title":"Ment. Health Phys. Act."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/10901981221090155","article-title":"Exercise in the treatment of addiction: A systematic literature review","volume":"49","author":"Patterson","year":"2022","journal-title":"Health Educ. Behav."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Dineen, T.E., Bean, C., Cranston, K.D., MacPherson, M.M., and Jung, M.E. (2021). Fitness Facility Staff Can Be Trained to Deliver a Motivational Interviewing-Informed Diabetes Prevention Program. Front. Public Health, 9.","DOI":"10.3389\/fpubh.2021.728612"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3109\/10826084.2015.1013131","article-title":"Sobriety Treatment and Recovery Teams: Implementation Fidelity and Related Outcomes","volume":"50","author":"Huebner","year":"2015","journal-title":"Subst. Use Misuse"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/camh.12671","article-title":"Therapeutic alliance in the treatment of adolescent substance misuse: A systematic review","volume":"29","author":"Sulaman","year":"2024","journal-title":"Child Adolesc. Ment. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12982-025-00696-2","article-title":"Implementing and documenting cultural adaption of evidence-based practice strategies to reduce opioid overdose deaths: Examples and lessons from the HEALing communities study","volume":"22","author":"Gibson","year":"2025","journal-title":"Discov. Public Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"383","DOI":"10.31189\/2165-7629-13-s2.383","article-title":"Call for Action: Guidelines for Physical Activity Based Interventions in Addiction","volume":"13","author":"Gould","year":"2024","journal-title":"J. Clin. Exerc. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0895-4356(98)00131-0","article-title":"The Delphi list: A criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus","volume":"51","author":"Verhagen","year":"1998","journal-title":"J. Clin. Epidemiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13011-025-00635-z","article-title":"Use of alternative payment models for substance use disorder prevention in the United States: Development of a conceptual framework","volume":"20","author":"Rosenfeld","year":"2025","journal-title":"Subst. Abus. Treat. Prev. Policy"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13012-020-01076-x","article-title":"A facilitation model for implementing quality improvement practices to enhance outpatient substance use disorder treatment outcomes: A stepped-wedge randomized controlled trial study protocol","volume":"16","author":"Lincourt","year":"2021","journal-title":"Implement. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1748-5908-2-40","article-title":"A conceptual framework for implementation fidelity","volume":"2","author":"Carroll","year":"2007","journal-title":"Implement. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pbb.2018.12.003","article-title":"Heart rate variability in alcohol use: A review","volume":"176","author":"Ralevski","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Penzlin, A.I., Barlinn, K., Illigens, B.M.-W., Weidner, K., Siepmann, M., and Siepmann, T. (2017). Effect of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients\u2013a one-year follow-up. BMC Psychiatry, 17.","DOI":"10.1186\/s12888-017-1480-2"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Agarwal, K., Manza, P., Chapman, M., Nawal, N., Biesecker, E., McPherson, K., Dennis, E., Johnson, A., Volkow, N.D., and Joseph, P.V. (2022). Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.863734"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Millet, G.P., and Chamari, K. (2022). Look to the stars-Is there anything that public health and rehabilitation can learn from elite sports?. Front. Sports Act. Living, 4.","DOI":"10.3389\/fspor.2022.1072154"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13643-020-01542-z","article-title":"PRISMA-S: An extension to the PRISMA Statement for Reporting Literature Searches in Systematic Reviews","volume":"10","author":"Rethlefsen","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: Advancing the methodology","volume":"5","author":"Levac","year":"2010","journal-title":"Implement. 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