{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:28:41Z","timestamp":1786613321282,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>The Functional Lumen Imaging Probe (EndoFLIP\u00ae) system is an impedance-based technology providing real-time measurements of cross-sectional area (CSA) and intraballoon pressure across a luminal segment. Initially developed for esophagogastric junction (EGJ) evaluation in achalasia, the application of EndoFLIP has subsequently expanded to the assessment of both sphincteric and non-sphincteric regions throughout the gastrointestinal tract in a variety of clinical conditions, including eosinophilic esophagitis (EoE), post-fundoplication states, and gastroparesis. Its unique ability to be utilized in both the diagnostic and therapeutic settings, including the assessment of treatment response, makes it a valuable tool in the overall management of gastrointestinal motility disorders. The present review extends beyond a simple overview of EndoFLIP applications by providing a comprehensive evaluation of its performance in comparison with other diagnostic modalities, as well as the current knowledge gaps regarding its use. Study limitations and procedure-related aspects requiring further investigation are critically discussed, with the aim of supporting and guiding future research in this field.<\/jats:p>","DOI":"10.3390\/diseases14080292","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:06:16Z","timestamp":1786608376000},"page":"292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Lumen Imaging Probe (EndoFLIP) in Upper Gastrointestinal Disorders: Current Evidence, Clinical Applications, and Future Perspectives"],"prefix":"10.3390","volume":"14","author":[{"given":"Theodoros A.","family":"Voulgaris","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Second Academic Surgical Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3103-2638","authenticated-orcid":false,"given":"Dimitrios I.","family":"Ziogas","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Second Academic Surgical Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece"},{"name":"Department of Gastroenterology, Athens Naval Hospital, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Stasinos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, 417 Army Equity Fund Hospital (NIMTS), 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8791-9954","authenticated-orcid":false,"given":"Eleni","family":"Koukoulioti","sequence":"additional","affiliation":[{"name":"Second Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Koukouvaidou","sequence":"additional","affiliation":[{"name":"Second Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Vezakis","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Second Academic Surgical Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7368-6168","authenticated-orcid":false,"given":"Ioannis S.","family":"Papanikolaou","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Second Academic Surgical Unit, National and Kapodistrian University of Athens, Aretaieion Hospital, 11528 Athens, Greece"},{"name":"Second Academic Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e13980","DOI":"10.1111\/nmo.13980","article-title":"The use of impedance planimetry (Endoscopic Functional Lumen Imaging Probe, EndoFLIP\u00ae) in the gastrointestinal tract: A systematic review","volume":"32","author":"Desprez","year":"2020","journal-title":"Neurogastroenterol. 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