{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:09:06Z","timestamp":1790010546212,"version":"4.0.1"},"reference-count":79,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cLe Fonds de la Recherche Scientifique\u201d\u2014FRNS","award":["F 5\/4\/150\/5\u2014SPD"],"award-info":[{"award-number":["F 5\/4\/150\/5\u2014SPD"]}]},{"award":["F 5\/4\/150\/5\u2014SPD"],"award-info":[{"award-number":["F 5\/4\/150\/5\u2014SPD"]}],"id":[{"id":"https:\/\/ror.org\/03q83t159","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: Pancreatic cancer (PC) is characterized by poor survival and a substantial psychological burden. Growing evidence suggests that individuals diagnosed with PC are at an increased risk of suicide. This systematic review aimed to synthesize the available evidence on suicide risk among patients with PC and to identify factors associated with increased vulnerability. Methods: Following the PRISMA 2020 guidelines, a systematic review of the PubMed\/MEDLINE and Scopus databases was conducted in August 2026. Of the 1015 records initially identified, 23 studies published between 2010 and July 2026 were included. Eligible studies specifically examined suicide risk among patients with PC using registry-based, administrative, or death certificate data. Risk of bias was assessed using the ROBINS-E tool. Results: Most included studies reported a higher suicide risk among patients with PC compared with the general population and, in many analyses, compared with patients with other cancer types. Large population-based studies generally reported standardized mortality ratios of approximately 2 to 11, although substantially higher estimates were observed in selected populations and specific subgroups. Suicide risk was particularly elevated during the early post-diagnosis period (with several studies identifying the greatest excess risk within the first two months following diagnosis), remained elevated throughout the first year and gradually declined thereafter. Male sex emerged as the most consistently demonstrated risk factor for suicide, while associations with unmarried status were observed across several studies but were derived largely from partially overlapping SEER-based cohorts. Additional evidence suggests a potential role for social vulnerability and poor prognostic factors. Conclusions: Despite the predominantly observational nature of the available evidence, the consistency of the findings highlights the importance of increased awareness of suicide vulnerability among patients with PC and supports consideration of psychosocial assessment and mental health support within routine pancreatic cancer care. Future prospective studies are needed to better characterize high-risk patients and to inform targeted suicide prevention strategies.<\/jats:p>","DOI":"10.3390\/diseases14090346","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:06:51Z","timestamp":1790006811000},"page":"346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Suicide Risk and Associated Factors in Patients with Pancreatic Cancer: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Maxence","family":"Chicoisneau","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Christelle","family":"Bouchart","sequence":"additional","affiliation":[{"name":"Institut Jules Bordet, Hopital Universitaire de Bruxelles (H.U.B.), Department of Radiotherapy-Oncology, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"},{"name":"Laboratory of Experimental Gastroenterology, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-1653","authenticated-orcid":false,"given":"Matthieu","family":"Hein","sequence":"additional","affiliation":[{"name":"CHU Brugmann, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1020 Brussels, Belgium"},{"name":"Laboratoire de Psychologie M\u00e9dicale et Addictologie (ULB312), Universit\u00e9 Libre de Bruxelles, ULB, 1020 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: A review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41416-025-03274-0","article-title":"Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy","volume":"134","author":"Bouchart","year":"2026","journal-title":"Br. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Manderlier, M., Navez, J., Hein, M., Engelholm, J.L., Closset, J., Bali, M.A., Van Gestel, D., Moretti, L., Van Laethem, J.L., and Bouchart, C. (2022). Isotoxic High-Dose Stereotactic Body Radiotherapy (iHD-SBRT) Versus Conventional Chemoradiotherapy for Localized Pancreatic Cancer: A Single Cancer Center Evaluation. Cancers, 14.","DOI":"10.3390\/cancers14235730"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hein, M., and Bouchart, C. (2025). Impact of Depression on Mortality in Patients with Pancreatic Cancer: A Systematic Review. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32090511"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","article-title":"Pancreatic cancer","volume":"405","author":"Stoop","year":"2025","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Deori, C., Andreis, F., Giubileo, V., Noventa, S., Oneda, E., Meriggi, F., and Zaniboni, A. (2025). Depression as a prodromal symptom of pancreatic cancer: A narrative review. Cancers, 18.","DOI":"10.3390\/cancers18010016"},{"key":"ref_7","unstructured":"National Comprehensive Cancer Network (2025). NCCN Clinical Practice Guidelines in Oncology: Pancreatic Adenocarcinoma, National Comprehensive Cancer Network. [2nd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1192\/bjp.2025.10363","article-title":"Association between recent cancer and suicide: Danish national cohort study","volume":"229","author":"Fitzgerald","year":"2026","journal-title":"Br. J. Psychiatry"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"972908","DOI":"10.3389\/fonc.2022.972908","article-title":"Incidence and risk factors of suicide among patients with pancreatic cancer: A population-based analysis from 2000 to 2018","volume":"12","author":"Ma","year":"2022","journal-title":"Front Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jamapsychiatry.2018.3181","article-title":"Risk of suicide after cancer diagnosis in England","volume":"76","author":"Henson","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/cncr.25428","article-title":"Suicide in patients with pancreatic cancer","volume":"117","author":"Turaga","year":"2011","journal-title":"Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e2251863","DOI":"10.1001\/jamanetworkopen.2022.51863","article-title":"Suicide risk among individuals diagnosed with cancer in the US, 2000\u20132016","volume":"6","author":"Hu","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/cncr.31876","article-title":"Suicidal death within a year of a cancer diagnosis: A population-based study","volume":"125","author":"Saad","year":"2019","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Watanabe, K., Nakamura, S., Chei, C.L., and Narimatsu, H. (2025). Suicide risk transition and cumulative incidence post-cancer diagnosis: Retrospective cohort study utilizing population-based cancer registry in Japan. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14635-6"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1158\/1055-9965.EPI-10-0261","article-title":"Suicide rates and risk factors among Korean cancer patients, 1993-2005","volume":"19","author":"Ahn","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/13811118.2013.722056","article-title":"Suicide in cancer patients in California, 1997\u20132006","volume":"16","author":"Nasseri","year":"2012","journal-title":"Arch. Suicide Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/pon.4827","article-title":"Suicide rates among patients with cancers of the digestive system","volume":"27","author":"Anderson","year":"2018","journal-title":"Psychooncology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e049358","DOI":"10.1136\/bmjopen-2021-049358","article-title":"Suicide after cancer diagnosis in South Korea: A population-based cohort study","volume":"11","author":"Choi","year":"2021","journal-title":"BMJ Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1245\/s10434-023-13471-x","article-title":"Suicidal Ideation Among Patients with Gastrointestinal Cancer","volume":"30","author":"Katayama","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"119813","DOI":"10.1016\/j.jad.2025.119813","article-title":"Suicide rates and methods among veteran cancer survivors within the Veterans Health Administration (VHA), 2010\u20132020","volume":"390","author":"Kittel","year":"2025","journal-title":"J. Affect. Disord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e47381","DOI":"10.1097\/MD.0000000000047381","article-title":"Cause-specific mortality in a population-level cohort of pancreatic cancer patients following chemotherapy: A SEER-based study","volume":"105","author":"Gao","year":"2026","journal-title":"Medicine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/aje\/kwaf201","article-title":"Suicide mortality trends among cancer patients in Taiwan: Suicide prevention efforts and cancer care improvements","volume":"195","author":"Hsiao","year":"2026","journal-title":"Am. J. Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Listabarth, S., Sommer, L., Trojer, A., Weber, S., Gr\u00f6mer, M., Waldhoer, T., Hackl, D., Vyssoki, B., Masel, E.K., and Unseld, M. (2026). Suicide Rates Among Patients Receiving Palliative Care-Descriptive Results of a National Cohort Study. J. Clin. Med., 15.","DOI":"10.3390\/jcm15062149"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1097\/CEJ.0000000000000375","article-title":"Increasing suicide risk among cancer patients in Lithuania from 1993 to 2012: A cancer registry-based study","volume":"26","author":"Kaceniene","year":"2017","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101601","DOI":"10.1016\/j.canep.2019.101601","article-title":"Socioeconomic predictors of suicide risk among cancer patients in the United States: A population-based study","volume":"63","year":"2019","journal-title":"Cancer Epidemiol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Su, C., Wang, Y., Wu, F., Qiu, Y., and Tao, J. (2022). Suicide and Cardiovascular Death Among Patients with Multiple Primary Cancers in the United States. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.857194"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1001\/jamaoncol.2022.6549","article-title":"Incidence, Timing, and Factors Associated with Suicide Among Patients Undergoing Surgery for Cancer in the US","volume":"9","author":"Potter","year":"2023","journal-title":"JAMA Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Michalek, I.M., Caetano Dos Santos, F.L., Wojciechowska, U., and Didkowska, J. (2023). Suicide after a Diagnosis of Cancer: Follow-Up of 1.4 Million Individuals, 2009\u20132019. Cancers, 15.","DOI":"10.3390\/cancers15174315"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102826","DOI":"10.1016\/j.eclinm.2024.102826","article-title":"Early, medium and long-term mental health in cancer survivors compared with cancer-free comparators: Matched cohort study using linked UK electronic health records","volume":"76","author":"Forbes","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/aac2.12069","article-title":"Risk factors for suicide in patients with pancreatic ductal adenocarcinoma: A population-based study","volume":"5","author":"Wang","year":"2024","journal-title":"Aging Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/cncr.35118","article-title":"Prognosis and risk of suicide after cancer diagnosis","volume":"130","author":"Kinslow","year":"2024","journal-title":"Cancer"},{"key":"ref_32","unstructured":"Agence nationale d\u2019accr\u00e9ditation et d\u2019\u00e9valuation en sant\u00e9 (Haute autorit\u00e9 de la sant\u00e9) (2026, July 01). Analyse de la Litt\u00e9rature et Gradation des Recommandations, Available online: https:\/\/www.has-sante.fr\/jcms\/c_434715\/fr\/guide-d-analyse-de-la-litterature-et-gradation-des-recommandations."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108602","DOI":"10.1016\/j.envint.2024.108602","article-title":"A tool to assess risk of bias in non-randomized follow-up studies of exposure effects (ROBINS-E)","volume":"186","author":"Higgins","year":"2024","journal-title":"Environ. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1758835920936093","DOI":"10.1177\/1758835920936093","article-title":"Novel strategies using modern radiotherapy to improve pancreatic cancer outcomes: Toward a new standard?","volume":"12","author":"Bouchart","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1245\/s10434-020-09568-2","article-title":"What Should Guide the Performance of Venous Resection During Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma with Venous Contact?","volume":"28","author":"Navez","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1408762","DOI":"10.3389\/fpsyt.2024.1408762","article-title":"Research progress on the psychological burden and intervention measures in cancer patients","volume":"15","author":"Wang","year":"2024","journal-title":"Front Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S2215-0366(14)70313-X","article-title":"Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: A cross-sectional analysis of routinely collected clinical data","volume":"1","author":"Walker","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/jncimonographs\/lgh014","article-title":"Prevalence of depression in patients with cancer","volume":"32","author":"Massie","year":"2004","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: From evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S1470-2045(04)01597-9","article-title":"Stress, depression, the immune system, and cancer","volume":"5","author":"Reiche","year":"2004","journal-title":"Lancet Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e2339116","DOI":"10.1001\/jamanetworkopen.2023.39116","article-title":"Chemotherapy-Related Toxic Effects and Quality of Life and Physical Functioning in Older Patients","volume":"6","author":"Baltussen","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.31557\/APJCP.2023.24.3.769","article-title":"Prevalence and Impact of Fatigue on Quality of Life (QOL) of Cancer Patients Undergoing Chemotherapy: A Systematic Review and Meta-Analysis","volume":"24","author":"Muthanna","year":"2023","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_44","first-page":"6385","article-title":"The economic impact of cancer diagnosis to individuals and their families: A systematic review","volume":"30","author":"Alzehr","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wi\u0119ckiewicz, G., Weber, S., Florczyk, I., and Gorczyca, P. (2024). Socioeconomic Burden of Psychiatric Cancer Patients: A Narrative Review. Cancers, 16.","DOI":"10.3390\/cancers16061108"},{"key":"ref_46","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/annonc\/mdm127","article-title":"Prognosis for long-term survivors of cancer","volume":"18","author":"Houterman","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/clinchem\/hvad202","article-title":"Epidemiology of Cancer","volume":"70","author":"Schwartz","year":"2024","journal-title":"Clin. Chem."},{"key":"ref_49","first-page":"221","article-title":"Suicide in Patients with Cancer: Identifying the Risk Factors","volume":"33","author":"McFarland","year":"2019","journal-title":"Oncology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.gtc.2024.09.006","article-title":"Pancreatic Cancer: Screening and Early Detection","volume":"54","author":"Mohamed","year":"2025","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.31557\/APJCP.2024.25.7.2483","article-title":"Characterizing the Physical and Psychological Experiences of Newly Diagnosed Pancreatic Cancer Patients","volume":"25","author":"Ibrahim","year":"2024","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.pan.2015.05.471","article-title":"Pancreatic cancer: Patient and caregiver perceptions on diagnosis, psychological impact, and importance of support","volume":"15","author":"Engebretson","year":"2015","journal-title":"Pancreatology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e695","DOI":"10.1136\/bmjspcare-2021-003266","article-title":"Coping in patients with pancreatic cancer: A scoping review and narrative synthesis","volume":"13","author":"Ristau","year":"2024","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"23743735231215605","DOI":"10.1177\/23743735231215605","article-title":"From Surviving to Living (on): A Grounded Theory Study on Coping in People with Pancreatic Cancer","volume":"10","author":"Ristau","year":"2023","journal-title":"J. Patient Exp."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e84919","DOI":"10.7554\/eLife.84919","article-title":"Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records","volume":"12","author":"Hjaltelin","year":"2023","journal-title":"Elife"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3390\/curroncol28040244","article-title":"Symptom Burden of Patients with Advanced Pancreas Cancer (APC): A Provincial Cancer Institute Observational Study","volume":"28","author":"Lelond","year":"2021","journal-title":"Curr. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e200643","DOI":"10.1001\/jamanetworkopen.2020.0643","article-title":"Association of Disease Progression with Health-Related Quality of Life Among Adults With Breast, Lung, Pancreatic, and Colorectal Cancer","volume":"3","author":"Marschner","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Cipora, E., Czerw, A., Partyka, O., Pajewska, M., Badowska-Kozakiewicz, A., Fudalej, M., Sygit, K., Kaczmarski, M., Krzych-Fa\u0142ta, E., and Jurczak, A. (2023). Quality of Life in Patients with Pancreatic Cancer-A Literature Review. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064895"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/NCC.0000000000000463","article-title":"The Symptom Experience of Patients with Advanced Pancreatic Cancer: An Integrative Review","volume":"41","author":"Tang","year":"2018","journal-title":"Cancer Nurs."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/jjco\/hyv169","article-title":"Prevalence and predictive factors of depression and anxiety in patients with pancreatic cancer: A longitudinal study","volume":"46","author":"Akizuki","year":"2016","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/NMD.0000000000000593","article-title":"Pancreatic Cancer and Depression: A Narrative Review","volume":"205","author":"Parker","year":"2017","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/pon.1697","article-title":"Psychological distress in patients with pancreatic cancer--an understudied group","volume":"19","author":"Clark","year":"2010","journal-title":"Psychooncology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.12998\/wjcc.v11.i12.2631","article-title":"Pancreatic cancer and depression","volume":"11","author":"Michoglou","year":"2023","journal-title":"World J. Clin. Cases"},{"key":"ref_64","first-page":"e9969","article-title":"The Role of Interleukin-6 and Inflammatory Cytokines in Pancreatic Cancer-Associated Depression","volume":"12","author":"Jara","year":"2020","journal-title":"Cureus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12032-025-02763-9","article-title":"Molecular mechanisms and clinical value of the correlation between depression and cancer","volume":"42","author":"Chen","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MPA.0000000000001024","article-title":"Early Detection of Pancreatic Cancer: The Role of Depression and Anxiety as a Precursor for Disease","volume":"47","author":"Kenner","year":"2018","journal-title":"Pancreas"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Frangie Machado, M., Masoumi, N., Azari, L., Centrella, M., Mukenschnabl, K., Lin, Y.C., Hodul, P., Islam, J.Y., Turner, K., and Alishahi Tabriz, A. (2026). Depression as a potential early indicator of pancreatic cancer: A systematic review of prevalence, mechanisms, and temporal associations. J. Psychosoc. Oncol.","DOI":"10.1080\/07347332.2026.2679587"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/MPA.0000000000001016","article-title":"Understanding the Pathophysiology of Psychological Distress and Pancreatic Cancer: A Systematic Review","volume":"47","author":"Bettison","year":"2018","journal-title":"Pancreas"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17588359211045860","DOI":"10.1177\/17588359211045860","article-title":"Isotoxic high-dose stereotactic body radiotherapy integrated in a total multimodal neoadjuvant strategy for the treatment of localized pancreatic ductal adenocarcinoma","volume":"13","author":"Bouchart","year":"2021","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bouchart, C., Navez, J., Borbath, I., Geboes, K., Vandamme, T., Closset, J., Moretti, L., Demetter, P., Paesmans, M., and Van Laethem, J.L. (2023). Preoperative treatment with mFOLFIRINOX or Gemcitabine\/Nab-paclitaxel +\/\u2212 isotoxic high-dose stereotactic body Radiation Therapy (iHD-SBRT) for borderline resectable pancreatic adenocarcinoma (the STEREOPAC trial): Study protocol for a randomised comparative multicenter phase II trial. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11327-x"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1056\/NEJMoa2605555","article-title":"Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer","volume":"395","author":"Wainberg","year":"2026","journal-title":"N. Engl. J. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1627422","DOI":"10.3389\/fpsyt.2025.1627422","article-title":"Psychological capital and death anxiety in pancreatic cancer patients: A latent profile analysis","volume":"16","author":"Yang","year":"2025","journal-title":"Front Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"450","DOI":"10.6004\/jnccn.2023.0026","article-title":"NCCN Guidelines\u00ae Insights: Distress Management, Version 2.2023","volume":"21","author":"Riba","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Bogn\u00e1r, A.S., S\u00fck\u00f6s, D.A., Patoni, C., Szalai, E.\u00c1., Teutsch, B., Veres, D.S., Hossz\u00fafalusi, N., Er\u0151ss, B.M., M\u00e1rta, K., and Hegyi, P. (2026). One out of four patients with pancreatic cancer experience psychological symptoms: A systematic review and meta-analysis. PLoS ONE, 21.","DOI":"10.1371\/journal.pone.0348435"},{"key":"ref_75","unstructured":"Pancreatic Cancer UK (2025). NICE Guideline 4: Emotional (Psychological) Support, Pancreatic Cancer UK."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/jgh.13172","article-title":"The prognostic factors and trajectory of HRQOL in patients with pancreatic cancer who received psychiatric intervention","volume":"31","author":"Sugimoto","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_77","first-page":"250","article-title":"The impact of early palliative care on the quality of life of patients with advanced pancreatic cancer: The IMPERATIVE case-crossover study","volume":"31","author":"Kim","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Subramaniam, D.S., Zhang, Z., Timmer, Z., DeMarco, E.C., Poirier, M.P., and Hinyard, L.J. (2024). Palliative Care and Mental Health among Pancreatic Cancer Patients in the United States: An Examination of Service Utilization and Health Outcomes. Healthcare, 12.","DOI":"10.3390\/healthcare12080842"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00127-015-1119-x","article-title":"The accuracy of suicide statistics: Are true suicide deaths misclassified?","volume":"51","author":"Bakst","year":"2016","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/14\/9\/346\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:26:21Z","timestamp":1790007981000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/14\/9\/346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":79,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["diseases14090346"],"URL":"https:\/\/doi.org\/10.3390\/diseases14090346","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}