{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:28:59Z","timestamp":1790731739331,"version":"4.1.0"},"reference-count":114,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III, Spain and Fondo Europeo de Desarrollo Regional","award":["PI13\/00129"],"award-info":[{"award-number":["PI13\/00129"]}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS-5725"],"award-info":[{"award-number":["CTS-5725"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission\/fusion, movements and turnover, are essential for the mitochondrial network quality control. Alterations in mitochondrial dynamics can cause neuropathies such as Charcot-Marie-Tooth disease in which mitochondrial fusion and transport are impaired, or dominant optic atrophy which is caused by a reduced mitochondrial fusion. On the other hand, mitochondrial dysfunction in primary mitochondrial diseases promotes reactive oxygen species production that impairs its own function and dynamics, causing a continuous vicious cycle that aggravates the pathological phenotype. Mitochondrial dynamics provides a new way to understand the pathophysiology of mitochondrial disorders and other diseases related to mitochondria dysfunction such as diabetes, heart failure, or Hungtinton\u2019s disease. The knowledge about mitochondrial dynamics also offers new therapeutics targets in mitochondrial diseases.<\/jats:p>","DOI":"10.3390\/diseases5010001","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T09:47:26Z","timestamp":1482486446000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Mitochondrial Dynamics in Mitochondrial Diseases"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6260-7284","authenticated-orcid":false,"given":"Juan","family":"Su\u00e1rez-Rivero","sequence":"first","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Villanueva-Paz","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"De la Cruz-Ojeda","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"De la Mata","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cot\u00e1n","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Oropesa-\u00c1vila","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"De Lavera","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"\u00c1lvarez-C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2957-7981","authenticated-orcid":false,"given":"Raquel","family":"Luz\u00f3n-Hidalgo","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"S\u00e1nchez-Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Raras, Instituto de Salud Carlos III, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mito.2016.07.003","article-title":"The rise of mitochondria in medicine","volume":"30","author":"Picard","year":"2016","journal-title":"Mitochondrion"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","article-title":"Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"key":"ref_3","unstructured":"Hofmann, S., and Bauer, M.F. 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