{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:15:27Z","timestamp":1760242527407,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Chronic pain in patients with chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS), NIH category III is difficult to treat without understanding its cause. The main symptom of chronic prostatitis is pain. In this study, we would like to explain the origin of pain in men with CP\/CPPS and its therapy. Forty-five patients with CP\/CPPS have received thermobalancing therapy (TT) enabled by Dr Allen\u2019s therapeutic device (DATD) for six months as mono-therapy. The control group comprised 45 men with CP\/CPPS did not receive TT. Before and after six months the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) scores, prostatic volume (PV) by ultrasound measurement and uroflowmetry (Qmax) were compared between the groups. Baseline characteristics have shown no difference. After TT, significant improvements in pain score (p &lt; 0.001), quality of life index (QoL) (p &lt; 0.001), decrease of PV (p &lt; 0.001), and increase Qmax (p &lt; 0.001) were determined. There were not noteworthy changes in the control group. Chronic pain due to CP\/CPPS happens as a consequence and challenges at the capillary level, namely pathological capillary activity. In response to initial triggers\u2014such as inflammation, cold, psychological and other factors\u2014constriction and spontaneous expansion of capillaries follows, creating a continuous secondary trigger\u2014i.e., the micro-focus of hypothermia\u2014which in turn provokes expansion of capillaries. The additional tissue due to vascular changes into the prostate increases pressure on nociceptors causing pain. TT relieves chronic pelvic pain by eliminating the lasting focus of hypothermia in the affected prostate tissue.<\/jats:p>","DOI":"10.3390\/diseases5040025","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T12:38:48Z","timestamp":1510144728000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Vascular Factor Plays the Main Role in the Cause of Pain in Men with Chronic Prostatitis and Chronic Pelvic Pain Syndrome: The Results of Clinical Trial on Thermobalancing Therapy"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-8439","authenticated-orcid":false,"given":"Simon","family":"Allen","sequence":"first","affiliation":[{"name":"Fine Treatment, 29 Rewley Road, Oxford OX1 2RA, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.juro.2017.01.035","article-title":"Chronic Prostate Inflammation Predicts Symptom Progression in Chronic Prostatitis\/Chronic Pelvic Pain (CP\/CPPS) Patients","volume":"198","author":"Nickel","year":"2017","journal-title":"J. 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