{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T12:27:08Z","timestamp":1769948828444,"version":"3.49.0"},"reference-count":18,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T00:00:00Z","timestamp":1529539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/201.322\/2016"],"award-info":[{"award-number":["E-26\/201.322\/2016"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["503024\/2014-7"],"award-info":[{"award-number":["503024\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Zika virus (ZIKV) infection usually presents as a mild and self-limited illness, but it may be associated with severe outcomes. We describe a case of a 30-year-old man with systemic erythematous lupus and common variable immunodeficiency who became infected with both Zika (ZIKV) and Chikungunya (CHIKV) virus during the 2016 outbreak in Rio de Janeiro, Brazil. The patient presented with intense wrist and right ankle arthritis, and ZIKV RNA and virus particles were detected in synovial tissue, blood and urine, and CHIKV RNA in serum sample, at the time of the diagnosis. During the follow up, ZIKV RNA persisted for 275 days post symptoms onset. The patient evolved with severe arthralgia\/arthritis and progressive deterioration of renal function. Fatal outcome occurred after 310 days post ZIKV and CHIKV co-infection onset. The results show the development of severe disease and fatal outcome of ZIKV infection in an immunosuppressed adult. The data suggests a correlation between immunodeficiency and prolonged ZIKV RNA shedding in both blood and urine with progressive disease. The results also indicate a possible role for arbovirus co-infections as risk factors for severe and fatal outcomes from ZIKV infection.<\/jats:p>","DOI":"10.3390\/diseases6030053","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T02:46:21Z","timestamp":1529635581000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fatal Human Case of Zika and Chikungunya Virus Co-Infection with Prolonged Viremia and Viruria"],"prefix":"10.3390","volume":"6","author":[{"given":"Kelly R.","family":"Silva","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Reumatologia, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-6617","authenticated-orcid":false,"given":"Blanca E. R. G.","family":"Bica","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatologia, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo S.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas e Parasit\u00e1rias, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"},{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro (FM\/UFRJ), Rio de Janeiro 21941590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo B.","family":"Serafim","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro (FM\/UFRJ), Rio de Janeiro 21941590, Brazil"},{"name":"Servi\u00e7o de Cl\u00ednica M\u00e9dica, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirhelen M.","family":"Abreu","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Reumatologia, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L. S.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro (IMPG\/UFRJ), Rio de Janeiro 21941902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa de S.","family":"Santana","sequence":"additional","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro (IMPG\/UFRJ), Rio de Janeiro 21941902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1755-999X","authenticated-orcid":false,"given":"Mauro J.","family":"Cabral-Castro","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro (FM\/UFRJ), Rio de Janeiro 21941590, Brazil"},{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro (IMPG\/UFRJ), Rio de Janeiro 21941902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Peralta","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro (FM\/UFRJ), Rio de Janeiro 21941590, Brazil"},{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro (IMPG\/UFRJ), Rio de Janeiro 21941902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta G.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Doen\u00e7as Infecciosas e Parasit\u00e1rias, Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (HUCFF\/UFRJ), Rio de Janeiro 21941590, Brazil"},{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro (IMPG\/UFRJ), Rio de Janeiro 21941902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcv.2016.10.024","article-title":"Zika v\u00edrus epidemic in Brazil. 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