{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:29:10Z","timestamp":1784291350497,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>The prevalence of dementia has substantially increased worldwide. Currently, there is no cure for dementia or Alzheimer\u2019s disease (AD), and care for affected patients is financially and psychologically costly. Of late, more attention has been given to preventive interventions\u2014in particular, physical activity\/exercise. In this review, examine the risk factors associated with AD and the effects physical activity may play in the prevention of the degenerative process of this disease, loss of memory and cognitive performance in the elderly. To date, research has shown that physical activity, especially aerobic exercise, has a protective effect on cognitive function and memory in the elderly and Alzheimer\u2019s patients. In comparison with aerobic exercise, several strength training studies have also shown positive effects, and the rare studies that compare the two different modalities show no difference.<\/jats:p>","DOI":"10.3390\/diseases8020018","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:19:39Z","timestamp":1591676379000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer\u2019s Diseases"],"prefix":"10.3390","volume":"8","author":[{"given":"Khadijeh","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Department of Sports Science and Physical Education, Marand Branch, Islamic Azad University, Marand 5418916571, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Jourkesh","sequence":"additional","affiliation":[{"name":"Department of Physical Education &amp; Sports Science, Islamic Azad University, Shabestar Branch 5381637181, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Sadigh-Eteghad","sequence":"additional","affiliation":[{"name":"Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz 5166614766, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R","family":"Stannard","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise, and Nutrition, Massey University, Palmerston North 4442, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-1268","authenticated-orcid":false,"given":"Conrad P.","family":"Earnest","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology, Texas A&amp;M University, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Ramsbottom","sequence":"additional","affiliation":[{"name":"Department of Sport, Health Sciences and Social Work, Oxford Brookes University, Oxford OX3 0BP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-1058","authenticated-orcid":false,"given":"Jose","family":"Antonio","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance, Nova Southeastern University, Davie, FL 32004, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khan H.","family":"Navin","sequence":"additional","affiliation":[{"name":"Immune Whey, Sugar Hill, GA 30518, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nlm.2014.12.005","article-title":"Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer\u2019s disease (APP\/PS1) transgenic mice","volume":"118","author":"Lin","year":"2015","journal-title":"Neurobiol. 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