{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:52:15Z","timestamp":1793829135326,"version":"4.6.1"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>The incidence of multiple pregnancies has increased in the last decades, mostly explained by the more frequent use of ovulation induction drugs and assisted reproduction techniques. Although single fetal death in the first trimester of twin pregnancy is not an uncommon event nor does it have serious consequences on the survival fetus, the death of one fetus in the second or third trimester of pregnancy is associated with a serious increase in morbidity and mortality for the surviving co-twin. Preterm labor, preeclampsia, intrauterine growth restriction (IUGR), neurological complications or even the death of the surviving twin have been associated with single fetal demise after mid gestation. We present a very rare case of twin pregnancy with single fetal demise at 26 weeks of gestation successfully managed to term.<\/jats:p>","DOI":"10.3390\/diseases9020033","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T05:10:55Z","timestamp":1619759455000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Single Fetal Demise in Twin Pregnancy\u2014A Great Concern but Still a Favorable Outcome"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-8210","authenticated-orcid":false,"given":"Bogdan Ioan","family":"Stefanescu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Pharmacy, University \u201dDunarea de Jos\u201d Galati, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Pharmacy, University \u201dDunarea de Jos\u201d Galati, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana Bianca","family":"Constantin","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University \u201dDunarea de Jos\u201d Galati, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Trus","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University \u201dDunarea de Jos\u201d Galati, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s13224-013-0500-5","article-title":"Review of twin pregnancies with single fetal death: Management, maternal and fetal outcome","volume":"64","author":"Jain","year":"2014","journal-title":"J. Obstet. Gynecol. India"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0002-9378(86)90068-2","article-title":"The \u201cvanishing twin\u201d: Ultrasonographic assessment of fetal disappearance in the first trimester","volume":"155","author":"Landy","year":"1986","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_3","first-page":"293","article-title":"Single foetal death in twin pregnancies: Review of the maternal and neonatal outcomes and management","volume":"6","author":"Woo","year":"2000","journal-title":"Hong Kong Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0028-2243(94)90064-7","article-title":"Monofetal death in multiple pregnancies: Risks for the co-Twin, risk factors and obstetrical management","volume":"55","author":"Gaucherand","year":"1994","journal-title":"Eur. J. Obs. Gynecol. Reprod. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/1471-0528.15530","article-title":"Prognosis of the co-twin following spontaneous single intrauterine fetal death in twin pregnancies: A systematic review and meta-analysis","volume":"126","author":"Mackie","year":"2019","journal-title":"BJOG Int. J. Obs. Gynaecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0002-9378(85)80152-6","article-title":"Twin pregnancy with intrauterine death of one twin","volume":"152","author":"Enbom","year":"1985","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.9790\/0853-13347983","article-title":"Conservative management of single fetal death in twin pregnancy at a tertiary health institution in southern Nigeria: A case report","volume":"13","author":"Babah","year":"2014","journal-title":"IOSR J. Dent. Med. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1479-828X.1992.tb01887.x","article-title":"Antenatal loss of one of twins","volume":"32","author":"Sonneveld","year":"1992","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1471-0528.1995.tb09021.x","article-title":"Expectant management of twin pregnancy with single fetal death","volume":"102","author":"Santema","year":"1995","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_10","unstructured":"Ward, R.H., and Whittle, M. (1995). Intrauterine death in a twin: Implications for the survivor. Multiple Pregnancy, RCOG Press."},{"key":"ref_11","first-page":"30","article-title":"Maternal and neonatal outcome of surviving twin after single fetal demise at 25 weeks: A rare case report","volume":"4","author":"Swarankar","year":"2017","journal-title":"Fertil. Sci. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3329\/dmcj.v6i1.35970","article-title":"Intrauterine Single Fetal Demise in Twin Pregnancy","volume":"6","author":"Haque","year":"2018","journal-title":"Delta Med Coll. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4274\/jtgga.galenos.2018.2018.0053","article-title":"Assesment of pregnancy outcomes among twin pregnancies with single fetal demise regarding chorionicity and fetal death time","volume":"20","author":"Api","year":"2019","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/uog.17426","article-title":"The influence of chorionicity and gestational age at single fetal loss on the risk of preterm birth in twin pregnancies: Analysis of the STORK multiple pregnancy cohort","volume":"50","author":"Thilaganathan","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/AOG.0b013e31822f129d","article-title":"Co-twin prognosis after single fetal death: A systematic review and meta-analysis","volume":"118","author":"Hillman","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_16","first-page":"41s","article-title":"Fetus papyraceus in twin pregnancy","volume":"51","author":"Livnat","year":"1978","journal-title":"Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1515\/JPM.1999.031","article-title":"Maternal and neonatal outcome of twin pregnancies 7 complicated by single fetal death","volume":"27","author":"Axt","year":"1999","journal-title":"J. Perinat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1056\/NEJM198403223101207","article-title":"Prolongation of a preterm pregnancy complicated by death of a single twin in utero and disseminated intravascular coagulation: Effects of treatment with heparin","volume":"310","author":"Romero","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"ref_19","first-page":"467","article-title":"Studies of fibrinogen and other haemostatic factors in women with intrauterine death and delayed delivery","volume":"101","author":"Pritchard","year":"1955","journal-title":"Surg. Gynecol. Obs."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4274\/tjod.35493","article-title":"Single intrauterine demise in twin pregnancies: Analysis of 29 cases","volume":"12","author":"Yaman","year":"2015","journal-title":"Turk. J. Obstet. Gynecol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S0001566000007480","article-title":"Intrauterine fetal demise in multiple gestation","volume":"33","author":"Newton","year":"1984","journal-title":"Acta Genet. Med. Gemellol. Twin Res."},{"key":"ref_22","first-page":"118","article-title":"Single fetal demise in twin pregnancy\u2014A case report","volume":"9","author":"Tasmin","year":"2016","journal-title":"Dinajpur Med. Coll. J."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/9\/2\/33\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:55:28Z","timestamp":1760162128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/9\/2\/33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["diseases9020033"],"URL":"https:\/\/doi.org\/10.3390\/diseases9020033","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]}}}