{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:11:41Z","timestamp":1785003101240,"version":"3.55.0"},"reference-count":123,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>In modern societies, ageing and obesity represent medical challenges for healthcare professionals and caregivers. Obesity and ageing share common features including the related cellular and molecular pathways as well as the impacts they have as risk factors for a variety of diseases and health problems. Both of these health problems also share exercise and a healthy lifestyle as the best therapeutic options. Importantly, ageing and obesity also have common epigenetic changes (histone modification, DNA methylation, noncoding RNAs, and chromatin remodeling) that are also impacted by exercise. This suggests that epigenetic pathways are among the mechanisms via which exercise induces its benefits, including ageing and obesity improvements. Exploring these interrelations and based on the fact that both ageing and obesity represent risk factors for each other, would lead to optimizing the available therapeutic approaches towards improved obesity management and healthy ageing.<\/jats:p>","DOI":"10.3390\/diseases9040087","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T03:12:56Z","timestamp":1638328376000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ageing and Obesity Shared Patterns: From Molecular Pathogenesis to Epigenetics"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-1119","authenticated-orcid":false,"given":"Abdelaziz","family":"Ghanemi","sequence":"first","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec City, QC G1V 4G2, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Laval University, Qu\u00e9bec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-9024","authenticated-orcid":false,"given":"Mayumi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec City, QC G1V 4G2, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Laval University, Qu\u00e9bec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-6127","authenticated-orcid":false,"given":"Jonny","family":"St-Amand","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Qu\u00e9bec City, QC G1V 4G2, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Laval University, Qu\u00e9bec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11357-016-9884-3","article-title":"Obesity and related consequences to ageing","volume":"38","author":"Jura","year":"2016","journal-title":"Age"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/bmb\/ldr002","article-title":"Obesity and weight management in the elderly","volume":"97","author":"Han","year":"2011","journal-title":"Br. 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