{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:39:18Z","timestamp":1762051158953,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Necrotizing periodontitis (NP) is a reactive and destructive inflammatory process that occurs in response to bacterial infection. Predisposing factors such as compromised host immune responses contribute significantly to NP pathogenesis. NP occasionally progresses to a more advanced and life-threatening state. Case presentation: A 73-year-old man in need of nursing care visited our dental clinic with severe gingival pain and intraoral bleeding. He had a disability and was immunocompromised because his medical history included cerebral infarction and type 2 diabetes mellitus. He was diagnosed with NP based on his typical symptoms, such as prominent bleeding and suppurative discharge from the gingiva, in addition to crater-shaped ulcerations of the interdental papillae. To improve daily oral hygiene, periodontists, dentists, and dental hygienists educated care workers and other staff at the nursing home on appropriate oral cleansing, including brushing three times a day using the Bass technique. Basic periodontal therapy, including whole-mouth scaling and debridement of the root surfaces using hand and ultrasonic instruments, was also performed. After this basic treatment of NP, we extracted the hopeless teeth. Currently, dentists visit the patient fortnightly to manage his oral hygiene. To date, good oral health has been maintained.<\/jats:p>","DOI":"10.3390\/dj10050079","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T08:04:21Z","timestamp":1651997061000},"page":"79","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Case of Necrotizing Periodontitis in a Care-Requiring Elderly Person Treated and Managed by Interprofessional Collaboration"],"prefix":"10.3390","volume":"10","author":[{"given":"Masahiko","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Iruma 350-0495, Japan"},{"name":"Kamimura Dental Orthodontic Clinic, Koshigaya 343-0823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-3604","authenticated-orcid":false,"given":"Ryutaro","family":"Kuraji","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo 102-8159, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kamimura","sequence":"additional","affiliation":[{"name":"Kamimura Dental Orthodontic Clinic, Koshigaya 343-0823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Numabe","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo 102-8159, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Iruma 350-0495, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Iruma 350-0495, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Kokabu","sequence":"additional","affiliation":[{"name":"Division of Molecular Signaling and Biochemistry, Kyushu Dental University, Kitakyushu 803-8580, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1111\/jcpe.12941","article-title":"Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo-periodontal lesions","volume":"45","author":"Herrera","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1902\/annals.1999.4.1.78","article-title":"Consensus report: Necrotizing periodontal diseases","volume":"4","author":"Lang","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.4103\/ccd.ccd_1181_16","article-title":"Necrotizing ulcerative gingivitis","volume":"8","author":"Malek","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1902\/annals.1999.4.1.74","article-title":"Necrotizing ulcerative periodontitis","volume":"4","author":"Novak","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1902\/annals.1999.4.1.65","article-title":"Necrotizing ulcerative gingivitis","volume":"4","author":"Rowland","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1002\/JPER.17-0733","article-title":"Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Jepsen","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_7","first-page":"57","article-title":"Necrotizing ulcerative periodontitis in an HIV patient","volume":"23","author":"Gowdey","year":"1995","journal-title":"J. Calif. Dent. Assoc."},{"key":"ref_8","first-page":"98","article-title":"The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count","volume":"12","author":"Phiri","year":"2010","journal-title":"J. Int. Acad. Periodontol."},{"key":"ref_9","first-page":"108","article-title":"Necrotising periodontal diseases","volume":"9","year":"2004","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1902\/jop.1995.66.11.990","article-title":"Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: Clinical staging and predisposing factors","volume":"66","author":"Horning","year":"1995","journal-title":"J. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1002\/JPER.17-0721","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-051X.1984.tb00900.x","article-title":"Demographic and clinical data associated with acute necrotizing ulcerative gingivitis in a dental school population (ANUG-demographic and clinical data)","volume":"11","author":"Stevens","year":"1984","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-051X.1987.tb00976.x","article-title":"A clinical, demographic and microbiologic study of ANUG patients in an urban dental school","volume":"14","author":"Falkler","year":"1987","journal-title":"J. Clin. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1902\/jop.1973.44.1.35","article-title":"Acute necrotizing ulcerative gingivitis: A survey of 218 cases","volume":"44","author":"Barnes","year":"1973","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1034\/j.1600-0765.2003.02011.x","article-title":"A TEM\/SEM study of the microbial plaque overlying the necrotic gingival papillae of HIV-seropositive, necrotizing ulcerative periodontitis","volume":"38","author":"Cobb","year":"2003","journal-title":"J. Periodontal Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1754-4505.1996.tb01546.x","article-title":"Clinical and radiographic presentations of HIV-1 necrotizing ulcerative periodontitis","volume":"16","author":"Barr","year":"1996","journal-title":"Spec. Care Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1902\/jop.1975.46.12.721","article-title":"The relationship of 17-hydroxycorticosteroid to acute necrotizing ulcerative gingivitis","volume":"46","author":"Maupin","year":"1975","journal-title":"J. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1902\/jop.1982.53.4.223","article-title":"The bacteriology of acute necrotizing ulcerative gingivitis","volume":"53","author":"Loesche","year":"1982","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1902\/jop.1986.57.3.141","article-title":"Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment","volume":"57","author":"Johnson","year":"1986","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1902\/jop.1993.64.11.1071","article-title":"Oral hygiene status and necrotizing ulcerative gingivitis in Nigerian children","volume":"64","author":"Taiwo","year":"1993","journal-title":"J. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/prd.12022","article-title":"Acute periodontal lesions","volume":"65","author":"Herrera","year":"2014","journal-title":"Periodontology 2000"},{"key":"ref_22","first-page":"d44","article-title":"Managing patients with necrotizing ulcerative periodontitis","volume":"79","author":"Todescan","year":"2013","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1308\/205016814813877234","article-title":"Prescribing for periodontal disease","volume":"3","author":"Blair","year":"2014","journal-title":"Prim. Dent. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ijom.2019.01.013","article-title":"Safety of tooth extraction in patients receiving direct oral anticoagulant treatment versus warfarin: A prospective observation study","volume":"48","author":"Yoshikawa","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11239-013-0967-z","article-title":"The pharmacology of novel oral anticoagulants","volume":"37","author":"DeWald","year":"2014","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1016\/j.oooo.2016.06.003","article-title":"Management of dental extraction in patients undergoing anticoagulant oral direct treatment: A pilot study","volume":"122","author":"Mauprivez","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.thromres.2015.05.001","article-title":"Direct Oral Anticoagulants (DOACs) in the laboratory: 2015 review","volume":"136","author":"Adcock","year":"2015","journal-title":"Thromb. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_29","first-page":"503","article-title":"Four-year cross-sectional study of bleeding risk in dental patients on direct oral anticoagulants","volume":"48","author":"Zeevi","year":"2017","journal-title":"Quintessence Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00784-015-1627-9","article-title":"Postoperative bleeding risk for oral surgery under continued rivaroxaban anticoagulant therapy","volume":"20","author":"Hanken","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1007\/s00784-016-2010-1","article-title":"Pragmatic approach to manage new oral anticoagulants in patients undergoing dental extractions: A prospective case-control study","volume":"21","author":"Miclotte","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.joms.2010.10.018","article-title":"Risk factors affecting postoperative hemorrhage after tooth extraction in patients receiving oral antithrombotic therapy","volume":"69","author":"Morimoto","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.joms.2016.04.007","article-title":"Postoperative bleeding following dental extractions in patients anticoagulated with warfarin","volume":"74","author":"Febbo","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.oooo.2014.10.011","article-title":"Dental surgery in anticoagulated patients\u2013stop the interruption","volume":"119","author":"Wahl","year":"2015","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_35","first-page":"105","article-title":"Antithrombotic therapy in dental practice","volume":"45","author":"Komatsu","year":"2021","journal-title":"Dent. J. Iwate Med. Univ."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/10\/5\/79\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:07:37Z","timestamp":1760137657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/10\/5\/79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,7]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["dj10050079"],"URL":"https:\/\/doi.org\/10.3390\/dj10050079","relation":{},"ISSN":["2304-6767"],"issn-type":[{"type":"electronic","value":"2304-6767"}],"subject":[],"published":{"date-parts":[[2022,5,7]]}}}