{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:39:05Z","timestamp":1787027945090,"version":"build-2736575974"},"reference-count":61,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Current research IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>A retrospective analysis was performed with the aim of understanding whether the risk factors showed in the literature for medication-related osteonecrosis of the jaws (MRONJ) in cancer patients are also relevant in osteoporotic patients taking antiresorptive drugs (ARDs). Data were retrospectively pooled from health records of patients on ARDs who requested a dental visit between January 2006 and April 2020 in the Dental Unit at Fondazione Ca\u2019 Granda IRCCS Ospedale Maggiore Policlinico, University of Milan. A total of 434 patients were included. The following variables were collected: sex, age, smoking habit, type of ARD, duration of treatment, route of administration, therapeutic indication, concurrent systemic therapies and pathologies. Statistical analysis confirmed the relevance of chemotherapy, smoking, and immunosuppressive drugs as risk factors. In addition, a higher frequency of MRONJ in osteoporotic patients was reported in our cohort in association with an immunodeficiency disorder of variable origin. In conclusion, the identification of individual risk-profile before dental treatments is crucial for prevention. Anamnesis should include main risk factors, such as immunosuppression, dental extractions, smoking, trauma, and poor dental health. Nevertheless, our suggestion for dental professionals is to conduct a complete medical history of patients who mention long-term per oral therapies with ARDs for osteoporosis. Osteoporotic, as well as cancer patients, may also benefit from periodic monitoring of the ARDs therapy in order to prevent MRONJ.<\/jats:p>","DOI":"10.3390\/dj10050089","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T12:25:57Z","timestamp":1652963157000},"page":"89","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Medication-Related Osteonecrosis of the Jaw in Dental Practice: A Retrospective Analysis of Data from the Milan Cohort"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-1421","authenticated-orcid":false,"given":"Cristina","family":"Mirelli","sequence":"first","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-9226","authenticated-orcid":false,"given":"Sonia","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bovio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-099X","authenticated-orcid":false,"given":"Sara","family":"Pederielli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Dall\u2019Agnola","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5983-9674","authenticated-orcid":false,"given":"Aldo Bruno","family":"Gianni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"},{"name":"UOC di Chirurgia Maxillo-Facciale e Odontostomatologia, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Via della Commenda 10, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-2633","authenticated-orcid":false,"given":"Roberto","family":"Biagi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, School of Dentistry, University of Milan, 20122 Milan, Italy"},{"name":"UOC di Chirurgia Maxillo-Facciale e Odontostomatologia, Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Via della Commenda 10, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. 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