{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:12:34Z","timestamp":1789600354874,"version":"build-2803163510"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs (MAFRA)","doi-asserted-by":"publisher","award":["316054-3"],"award-info":[{"award-number":["316054-3"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET)","award":["316054-3"],"award-info":[{"award-number":["316054-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Gingivitis and periodontitis are inflammatory disorders caused by dental plaque and calculus. These disorders often lead to tooth loss if not treated properly. Although antibiotics can be used, it is hard to treat them due to the difficulty in supplying effective doses of antibiotics to lesion areas and side effects associated with long-term use of antibiotics. In the present study, attempts were made to provide in vitro and in vivo evidence to support anti-inflammatory activities of TEES-10\u00ae, a mixture of ethanol extracts of Ligularia stenocephala (LSE) and Secale cereale L. sprout (SCSE) toward gingivitis and periodontitis by performing the following experiments. TEES-10\u00ae with a ratio of 6:4 (LSE:SCSE) showed the best effects in both stimulating the viability and inhibiting the cytotoxicity. In in vitro experiments, TEES-10\u00ae showed an ability to scavenge 2,2-diphenyl-1-picrylhydrazyl and superoxide radicals and remove ROS generated in periodontal ligament cells treated with lipopolysaccharide. TEES-10\u00ae also enhanced the viability of stem cells from human exfoliated deciduous teeth and stimulated the osteogenic differentiation of deciduous teeth cells. In in vivo experiments using rats with induced periodontitis, TEES-10\u00ae significantly decreased inflammatory cell infiltration and the numbers of osteoclasts, increased alveolar process volume and the numbers of osteoblasts, decreased serum levels of IL-1\u03b2 and TNF-\u03b1 (pro-inflammatory cytokines), and increased serum levels of IL-10 and IL-13 (anti-inflammatory cytokines). These results strongly support the theory that TEES-10\u00ae has the potential to be developed as a health functional food that can treat and prevent gingival and periodontal diseases and improve dental health.<\/jats:p>","DOI":"10.3390\/dj10080143","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T21:41:37Z","timestamp":1659476497000},"page":"143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vitro and In Vivo Anti-Inflammatory Effects of TEES-10\u00ae, a Mixture of Ethanol Extracts of Ligularia stenocephala Matsum. &amp; Koidz. and Secale cereale L. Sprout, on Gingivitis and Periodontitis"],"prefix":"10.3390","volume":"10","author":[{"given":"Seungah","family":"Lee","sequence":"first","affiliation":[{"name":"Naturesense Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Famenity Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkee","family":"Hong","sequence":"additional","affiliation":[{"name":"Famenity Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Ju","family":"Jeon","sequence":"additional","affiliation":[{"name":"Naturesense Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Famenity Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Famenity Co., Ltd., Uiwang-si 16006, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6408-1618","authenticated-orcid":false,"given":"Jin-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea"},{"name":"Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-6124","authenticated-orcid":false,"given":"Seong-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea"},{"name":"Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Kyeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Research Institute of Periodontal Regeneration, Yonsei University College of Dentistry, Seoul 03722, Korea"},{"name":"Innovation Research and Support Center for Dental Science, Yonsei University Dental Hospital, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7178-6501","authenticated-orcid":false,"given":"Moo-Ho","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheo 24341, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2249.2006.03028.x","article-title":"Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions","volume":"144","author":"Honda","year":"2006","journal-title":"Clin. 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