{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:58:46Z","timestamp":1791730726015,"version":"4.3.4"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Dental &amp; Craniofacial Research of the National Institutes of Health","award":["K23DE031021"],"award-info":[{"award-number":["K23DE031021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>The use of anticholinergic medications is increasing in younger ages, yet information about xerostomia, the most common anticholinergic side effect, is limited. This case\u2013control retrospective study examines the relationship between anticholinergic medication-induced xerostomia and caries status among adults between 18 and 65 years of age. The study sample comprised 649 cases with xerostomia and 649 age- and gender-matched controls. The anticholinergic burden was estimated using the anticholinergic drug scale (ADS). Caries experience was recorded by calculating the Decayed, Missing, Filled Tooth (DMFT) index. Individuals with xerostomia had a higher mean DMFT index (16.02 \u00b1 9.50), which corresponded with a higher level of anticholinergic exposure from medications (3.26 \u00b1 2.81) compared to their age and gender-matched controls without xerostomia (13.83 + 8.83 and 1.89 \u00b1 2.45, respectively). Logistic regression analysis verified the effects of DMFT, the total number of AC medications, and the ADS burden on xerostomia status. Comparing adults with or without xerostomia revealed statistical differences in several risk factors, such as smoking, diabetes, sleep apnea, and the utilization of anticholinergic medications. A personalized dental care plan should include the evaluation of the anticholinergic burden from medications regardless of the patient\u2019s age to prevent increased caries severity.<\/jats:p>","DOI":"10.3390\/dj11040087","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T04:31:05Z","timestamp":1679632265000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anticholinergic Medication and Caries Status Predict Xerostomia under 65"],"prefix":"10.3390","volume":"11","author":[{"given":"Hui Ling","family":"Cheah","sequence":"first","affiliation":[{"name":"General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gray","sequence":"additional","affiliation":[{"name":"General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahenda","family":"Aboelmagd","sequence":"additional","affiliation":[{"name":"General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Basir","family":"Barmak","sequence":"additional","affiliation":[{"name":"General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-7088","authenticated-orcid":false,"given":"Szilvia","family":"Arany","sequence":"additional","affiliation":[{"name":"General Dentistry, Department of Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"},{"name":"Specialty Care Clinic, Eastman Institute of Oral Health, University of Rochester, Rochester, NY 14620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ger.12101","article-title":"Prevalence and factors associated with xerostomia and hyposalivation among community-dwelling older people in Japan","volume":"33","author":"Ohara","year":"2013","journal-title":"Gerodontology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/ger.12214","article-title":"A risk prediction model for xerostomia: A retrospective cohort study","volume":"33","author":"Villa","year":"2016","journal-title":"Gerodontology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1067\/moe.2002.122434","article-title":"Late-life depression: Psychopathology, medical interventions, and dental implications","volume":"94","author":"Friedlander","year":"2002","journal-title":"Oral Surg. 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