{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:39:02Z","timestamp":1787027942928,"version":"build-2736575974"},"reference-count":106,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Catholic University of Cuenca, Cuenca, Ecuador","award":["PICODS21-38"],"award-info":[{"award-number":["PICODS21-38"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Asthma is a chronic, heterogeneous respiratory pathology characterized by reversible airway inflammation. Therapeutics focus on symptom reduction and control, aimed at preserving normal pulmonary function and inducing bronchodilatation. The objective of this review is to describe the adverse effects produced by anti-asthmatic drugs on dental health, according to the reported scientific evidence. A bibliographic review was carried out on databases, such as Web of science, Scopus, and ScienceDirect. Most anti-asthmatic medications are administered using inhalers or nebulizers, making it impossible to avoid contact of the drug with hard dental tissues and oral mucosa, and thus promoting a greater risk of oral alterations, mainly due to decreases in the salivary flow and pH. Such changes can cause diseases, such as dental caries, dental erosion, tooth loss, periodontal disease, bone resorption, as well as fungal infections, such as oral candidiasis.<\/jats:p>","DOI":"10.3390\/dj11050113","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T01:16:25Z","timestamp":1682471785000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Drugs Prescribed for Asthma and Their Adverse Effects on Dental Health"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-3218","authenticated-orcid":false,"given":"Edisson-Mauricio","family":"Pacheco-Quito","sequence":"first","affiliation":[{"name":"Academic Unit of Health and Wellness, Faculty of Dentistry, Catholic University of Cuenca, Cuenca 010105, Ecuador"},{"name":"Innovation and Pharmaceutical Development in Dentistry Research Group, Faculty of Dentistry, Head of Research and Innovation, Catholic University of Cuenca, Cuenca 010105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Ministry of Health, Dentistry Department, Cuenca 010105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4159-9286","authenticated-orcid":false,"given":"J\u00e9ssica","family":"Sarmiento-Ordo\u00f1ez","sequence":"additional","affiliation":[{"name":"Academic Unit of Health and Wellness, Faculty of Dentistry, Catholic University of Cuenca, Cuenca 010105, Ecuador"},{"name":"Innovation and Pharmaceutical Development in Dentistry Research Group, Faculty of Dentistry, Head of Research and Innovation, Catholic University of Cuenca, Cuenca 010105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-0114","authenticated-orcid":false,"given":"Katherine","family":"Cuenca-Le\u00f3n","sequence":"additional","affiliation":[{"name":"Academic Unit of Health and Wellness, Faculty of Dentistry, Catholic University of Cuenca, Cuenca 010105, Ecuador"},{"name":"Innovation and Pharmaceutical Development in Dentistry Research Group, Faculty of Dentistry, Head of Research and Innovation, Catholic University of Cuenca, Cuenca 010105, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101333","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic Mechanisms in Asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12948-020-00137-2","article-title":"Oral Health in Asthmatic Patients: A Review: Asthma and Its Therapy May Impact on Oral Health","volume":"18","author":"Gani","year":"2020","journal-title":"Clin. Mol. Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13223-017-0225-6","article-title":"Asthma","volume":"14","author":"Quirt","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1900491","DOI":"10.1183\/13993003.00491-2019","article-title":"Asthma Progression and Mortality: The Role of Inhaled Corticosteroids","volume":"54","author":"Fabbri","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fped.2019.00246","article-title":"Epidemiology of Asthma in Children and Adults","volume":"7","author":"Dharmage","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2013.00263","article-title":"Pathology of Asthma","volume":"4","author":"Kudo","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00281-020-00785-1","article-title":"Asthma Epidemiology and Risk Factors","volume":"42","author":"Stern","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.3389\/fimmu.2018.02997","article-title":"Sex Bias in Asthma Prevalence and Pathogenesis","volume":"9","author":"Shah","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_9","first-page":"1823","article-title":"Prevalence of Asthma and Its Management: A Review","volume":"68","author":"Rehman","year":"2018","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_10","unstructured":"(2023, April 11). Global Strategy for Asthma Management and Prevention. Available online: https:\/\/ginasthma.org\/wp-content\/uploads\/2021\/05\/GINA-Main-Report-2021-V2-WMS.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1183\/20734735.008115","article-title":"Clinical Asthma Phenotypes in the Real World: Opportunities and Challenges","volume":"11","author":"Bostantzoglou","year":"2015","journal-title":"Breathe"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijpam.2019.02.004","article-title":"The Prevalence of Childhood Asthma in Saudi Arabia","volume":"6","author":"Alahmadi","year":"2019","journal-title":"Int. J. Pediatr. Adolesc. Med."},{"key":"ref_13","first-page":"100916","article-title":"Asthma and Smoking: A Review","volume":"82","author":"Kamga","year":"2022","journal-title":"Respir. Med. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.jaci.2009.10.071","article-title":"Genetics of Allergic Disease","volume":"125","author":"Holloway","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ranjbar, M., Whetstone, C.E., Omer, H., Power, L., Cusack, R.P., and Gauvreau, G.M. (2022). The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma. Genes, 13.","DOI":"10.3390\/genes13101870"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2011.01029.x","article-title":"The Genetics of Asthma and Allergic Disease: A 21st Century Perspective","volume":"242","author":"Ober","year":"2011","journal-title":"Immunol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/alr.21609","article-title":"Asthma: Definitions and Pathophysiology","volume":"5","author":"Mims","year":"2015","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jaip.2017.05.001","article-title":"Asthma Exacerbations: Pathogenesis, Prevention, and Treatment","volume":"5","author":"Castillo","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_19","first-page":"113","article-title":"The Effects of Asthma and Asthma Medication on Dental Caries and Salivary Characteristics in Children","volume":"11","author":"Alaki","year":"2013","journal-title":"Oral Health Prev. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40733-016-0029-3","article-title":"Asthma Costs and Social Impact","volume":"3","author":"Nunes","year":"2017","journal-title":"Asthma Res. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40510-021-00351-x","article-title":"Allergies\/Asthma and Root Resorption: A Systematic Review","volume":"22","author":"Medina","year":"2021","journal-title":"Prog. Orthod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jds.2019.08.002","article-title":"Asthma Medication Increases Dental Caries among Children in Taiwan: An Analysis Using the National Health Insurance Research Database","volume":"14","author":"Wu","year":"2019","journal-title":"J. Dent. Sci."},{"key":"ref_23","unstructured":"(2022, May 22). GINA Report, Global Strategy for Asthma Management and Prevention. Available online: https:\/\/ginasthma.org\/gina-reports\/."},{"key":"ref_24","unstructured":"(2022, May 23). National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC)|NHLBI, NIH, Available online: https:\/\/www.nhlbi.nih.gov\/science\/national-asthma-education-and-prevention-program-naepp."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jama.292.3.367","article-title":"Pharmacological Management to Reduce Exacerbations in Adults with Asthma: A Systematic Review and Meta-Analysis","volume":"292","author":"Sin","year":"2004","journal-title":"J. Am. Med. Assoc."},{"key":"ref_26","first-page":"847","article-title":"Severe Asthma","volume":"111","author":"Lommatzsch","year":"2014","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4103\/ejd.ejd_65_17","article-title":"Assessment of the Oral Health Status of Asthmatic Children","volume":"11","author":"Arafa","year":"2017","journal-title":"Eur. J. Dent."},{"key":"ref_28","first-page":"665","article-title":"Knowledge Level Regarding the Prescription of Antibiotics within the Dentistry Field","volume":"41","year":"2022","journal-title":"Arch. Venez. Farmacol. Ter."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Velez-Le\u00f3n, E.M., Vargas, K.L., Cuenca-Le\u00f3n, K., Acurio-Vargas, C., Zumba, A., and Pacheco-Quito, E.M. (2022). Ambulatory Sedation for Dental Procedures-Case of Cuenca, Ecuador. Children, 9.","DOI":"10.3390\/children9111618"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5455\/medarh.2015.69.247-250","article-title":"Cariogenic Potential of Inhaled Antiasthmatic Drugs","volume":"69","author":"Brigic","year":"2015","journal-title":"Med. Arch."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5455\/msm.2015.27.237-240","article-title":"Antiasthmatic Inhaled Medications as Favoring Factors for Increased Concentration of Streptococcus Mutans","volume":"27","author":"Brigic","year":"2015","journal-title":"Mater. Socio Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1159\/000330233","article-title":"Cariogenic Microorganisms and Oral Conditions in Asthmatic Children","volume":"45","author":"Botelho","year":"2011","journal-title":"Caries Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1442-200X.2006.02281.x","article-title":"Oral and Dental Manifestations of Young Asthmatics Related to Medication, Severity and Duration of Condition","volume":"48","author":"Ersin","year":"2006","journal-title":"Pediatr. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3109\/00016357.2010.547516","article-title":"Oral Health in Young Adults with Long-Term, Controlled Asthma","volume":"69","author":"Stensson","year":"2011","journal-title":"Acta Odontol. Scand."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.24953\/turkjped.2021.01.009","article-title":"Oral Health Status of Asthmatic Children Using Inhaled Corticosteroids","volume":"63","author":"Soyer","year":"2021","journal-title":"Turk. J. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1834-7819.2010.01226.x","article-title":"Asthma and Oral Health: A Review","volume":"55","author":"Thomas","year":"2010","journal-title":"Aust. Dent. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5114\/jos.2021.104694","article-title":"The Effect of the Type of Inhaled Anti-Asthmatic Therapy on the Properties of Saliva in Children\u2014A Phantom Study","volume":"74","author":"Kulus","year":"2021","journal-title":"J. Stomatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034518816961","article-title":"Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health","volume":"98","author":"Dawes","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/ipd.12487","article-title":"Asthma and Oral Changes in Children: Associated Factors in a Community of Southern Brazil","volume":"29","author":"Rezende","year":"2019","journal-title":"Int. J. Paediatr. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1834-7819.2002.tb00541.x","article-title":"Dental Erosion in Asthma: A Case-Control Study from South East Queensland","volume":"47","author":"Sivasithamparam","year":"2002","journal-title":"Aust. Dent. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/sj.bdj.4811041","article-title":"A Multifactorial Analysis of Factors Associated with Dental Erosion","volume":"196","author":"Dugmore","year":"2004","journal-title":"Br. Dent. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.rmed.2008.09.002","article-title":"Lung Function and Asthma Control with Beclomethasone and Formoterol in a Single Inhaler","volume":"103","author":"Huchon","year":"2009","journal-title":"Respir. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"816","DOI":"10.5812\/ircmj.4658","article-title":"Effect of Inhaled Medication and Inhalation Technique on Dental Caries in Asthmatic Patients","volume":"14","author":"Boskabady","year":"2012","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_44","first-page":"254","article-title":"Oral Health Status in Preschool Asthmatic Children in Iran","volume":"12","author":"Ehsani","year":"2013","journal-title":"Iran J. Allergy Asthma Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0970-2113.110418","article-title":"Evaluation of Cariogenic Potential of Dry Powder Inhalers: A Case-Control Study","volume":"30","author":"Godara","year":"2013","journal-title":"Lung India"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4103\/2141-9248.139311","article-title":"Effect of Diuretics on Salivary Flow, Composition and Oral Health Status: A Clinico-Biochemical Study","volume":"4","author":"Prasanthi","year":"2014","journal-title":"Ann. Med. Health Sci. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00198-015-3089-y","article-title":"Impact of Treatment with Inhaled Corticosteroids on Bone Mineral Density of Patients with Asthma: Related with Age","volume":"26","author":"Monadi","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(16)31399-X","article-title":"Should Recommendations about Starting Inhaled Corticosteroid Treatment for Mild Asthma Be Based on Symptom Frequency: A Post-Hoc Efficacy Analysis of the START Study","volume":"389","author":"Reddel","year":"2017","journal-title":"Lancet"},{"key":"ref_49","first-page":"455","article-title":"Oral Health and Risk of Pneumonia in Asthmatic Pacients with Inhaled Treatment","volume":"150","author":"Duran","year":"2018","journal-title":"Med. Clin."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4103\/jomfp.JOMFP_235_15","article-title":"Oral Carriage of Cariogenic Bacteria and Candida Albicans in Asthmatic Adults before and after Anti-Asthma Medication: A Longitudinal Study","volume":"22","author":"Ashuja","year":"2018","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"103575","DOI":"10.1016\/j.micpath.2019.103575","article-title":"Characterization of Oral Candidiasis and the Candida Species Profile in Patients with Oral Mucosal Diseases","volume":"134","author":"Hu","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"em119","DOI":"10.29333\/ejgm\/93478","article-title":"Comparison of the Frequency of Dental Caries in Asthmatic Children under Treatment with Inhaled Corticosteroids and Healthy Children in Sabzevar in 2017\u20132018","volume":"16","author":"Hassanpour","year":"2019","journal-title":"Electron. J. Gen. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1080\/02770903.2018.1466315","article-title":"The Association between Bronchial Asthma and Periodontitis: A Case-Control Study in Jordan","volume":"56","author":"Khassawneh","year":"2019","journal-title":"J. Asthma."},{"key":"ref_54","first-page":"38","article-title":"Impact of Inhaler Use on Dental Caries in Asthma Pediatrics Patients: A Case-Control Study","volume":"118","year":"2020","journal-title":"Arch. Argent. Pediatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/scd.12462","article-title":"Impact of Asthma and Its Medication on Salivary Characteristics and Oral Health in Adolescents: A Cross-Sectional Comparative Study","volume":"40","author":"Bairappan","year":"2020","journal-title":"Spec. Care Dent."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e20200117","DOI":"10.36416\/1806-3756\/e20200117","article-title":"Oral Health-Related Quality of Life in Individuals with Severe Asthma","volume":"47","author":"Cruz","year":"2021","journal-title":"J. Bras. Pneumol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Akiki, Z., Saadeh, D., Farah, R., Hallit, S., Sacre, H., Hosseini, H., and Salameh, P. (2021). Asthma Prevalence and Associated Factors among Lebanese Adults: The First National Survey. BMC Pulm. Med., 21.","DOI":"10.1186\/s12890-021-01529-z"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/pai.13494","article-title":"Genome-Wide Association Studies of Exacerbations in Children Using Long-Acting Beta2-Agonists","volume":"32","author":"Slob","year":"2021","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.25122\/jml-2022-0142","article-title":"Salivary Candida Albicans in Asthmatic Patients Taking Anti-Asthmatic Medication","volume":"15","author":"Abidullah","year":"2022","journal-title":"J. Med. Life"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"203215","DOI":"10.1007\/s00210-008-0302-y","article-title":"Inhaled Corticosteroids and Long-Acting Beta-Agonists in Adult Asthma: A Winning Combination in All?","volume":"378","author":"Postma","year":"2008","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.rmed.2019.02.011","article-title":"Impact of EHealth on Medication Adherence among Patients with Asthma: A Systematic Review and Meta-Analysis","volume":"149","author":"Jeminiwa","year":"2019","journal-title":"Respir. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.rmed.2006.04.015","article-title":"The Dose-Response Characteristics of Inhaled Corticosteroids When Used to Treat Asthma: An Overview of Cochrane Systematic Reviews","volume":"100","author":"Adams","year":"2006","journal-title":"Respir. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1874306401408010059","article-title":"Systemic Effects of Inhaled Corticosteroids: An Overview","volume":"8","author":"Pandya","year":"2015","journal-title":"Open Respir. Med. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1164\/rccm.200801-060ST","article-title":"An Official American Thoracic Society\/European Respiratory Society Statement: Asthma Control and Exacerbations\u2014Standardizing Endpoints for Clinical Asthma Trials and Clinical Practice","volume":"180","author":"Reddel","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1183\/09031936.00166410","article-title":"What the Pulmonary Specialist Should Know about the New Inhalation Therapies","volume":"37","author":"Laube","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2223\/JPED.2024","article-title":"Advances in Inhalation Therapy in Pediatrics","volume":"86","year":"2010","journal-title":"J. Pediatr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1208\/s12249-014-0092-0","article-title":"Mechanisms of Pharmaceutical Aerosol Deposition in the Respiratory Tract","volume":"15","author":"Cheng","year":"2014","journal-title":"AAPS PharmSciTech"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40248-015-0012-5","article-title":"Dry Powder Inhalers and the Right Things to Remember: A Concept Review","volume":"10","year":"2015","journal-title":"Multidiscip. Respir. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.rmed.2010.04.012","article-title":"Choosing Inhaler Devices for People with Asthma: Current Knowledge and Outstanding Research Needs","volume":"104","author":"Haughney","year":"2010","journal-title":"Respir. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/00016357.2018.1436723","article-title":"Association between Age at Asthma Diagnosis and Tooth Loss","volume":"76","author":"Choi","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1542\/pir.2018-0282","article-title":"Asthma","volume":"40","author":"Patel","year":"2019","journal-title":"Pediatr. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/02770903.2017.1290105","article-title":"Long-Term Control Medication Use and Asthma Control Status among Children and Adults with Asthma","volume":"54","author":"Zahran","year":"2017","journal-title":"J. Asthma"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40733-021-00068-y","article-title":"Comparison of Dental Caries (DMFT and DMFS Indices) between Asthmatic Patients and Control Group in Iran: A Meta-Analysis","volume":"7","author":"Nasiri","year":"2021","journal-title":"Asthma Res. Pract."},{"key":"ref_74","first-page":"643","article-title":"Dental Caries in Saudi Arabia: A Systematic Review","volume":"16","author":"Alshammari","year":"2021","journal-title":"J. Taibah. Univ. Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"V\u00e9lez-Le\u00f3n, E.M., Albaladejo-Mart\u00ednez, A., Cuenca-Le\u00f3n, K., Encalada-Verdugo, L., Armas-Vega, A., and Melo, M. (2022). Caries Experience and Treatment Needs in Urban and Rural Environments in School-Age Children from Three Provinces of Ecuador: A Cross-Sectional Study. Dent. J., 10.","DOI":"10.3390\/dj10100185"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"V\u00e9lez-Le\u00f3n, E., Albaladejo, A., Cuenca-Le\u00f3n, K., Jim\u00e9nez-Romero, M., Armas-Vega, A., and Melo, M. (2022). Prevalence of Caries According to the ICDAS II in Children from 6 and 12 Years of Age from Southern Ecuadorian Regions. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19127266"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1159\/000321566","article-title":"Caries Prevalence, Caries-Related Factors and Plaque PH in Adolescents with Long-Term Asthma","volume":"44","author":"Stensson","year":"2011","journal-title":"Caries Res."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"V\u00e9lez-Le\u00f3n, E., Albaladejo-Mart\u00ednez, A., Pacheco-Quito, E.-M., Armas-Vega, A., Delgado-Gaete, A., Pes\u00e1ntez-Ochoa, D., and Melo, M. (2022). Developmental Enamel Defects in Children from the Southern Region of Ecuador. Children, 9.","DOI":"10.3390\/children9111755"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1590\/1678-7757-2016-0147","article-title":"Impact of Inhalation Therapy on the Incidence of Carious Lesions in Patients with Asthma and COPD","volume":"25","author":"Bozejac","year":"2017","journal-title":"J. Appl. Oral Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/02770903.2020.1826045","article-title":"Association between Asthma and Caries-Related Salivary Factors: A Meta-Analysis","volume":"59","year":"2022","journal-title":"J. Asthma"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/odi.13020","article-title":"Oral Microbiomes in Children with Asthma and Dental Caries","volume":"25","author":"Cherkasov","year":"2019","journal-title":"Oral Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1902\/jop.2006.060010","article-title":"Systematic Review of the Association Between Respiratory Diseases and Oral Health","volume":"77","author":"Azarpazhooh","year":"2006","journal-title":"J. Periodontol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.14219\/jada.archive.2010.0335","article-title":"Is There a Relationship between Asthma and Dental Caries?: A Critical Review of the Literature","volume":"141","author":"Shulman","year":"2010","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1080\/02770903.2020.1784196","article-title":"Association between Asthma and Dental Caries in US (United States) Adult Population","volume":"58","author":"Shah","year":"2021","journal-title":"J. Asthma"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/0970-4388.33450","article-title":"Effect of Antiasthmatic Medication on Dental Disease: Dental Caries and Periodontal Disease","volume":"25","author":"Shashikiran","year":"2007","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.14219\/jada.archive.2001.0365","article-title":"The Dental Patient with Asthma: An Update and Oral Health Considerations","volume":"132","author":"Steinbacher","year":"2001","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_87","first-page":"69","article-title":"Prevalence and Associated Factors of Oral Non-Candida Albicans Candida Carriage in Denture Wearers in Sana\u2019a City\u2014Yemen","volume":"3","year":"2018","journal-title":"Univers. J. Pharm. Res."},{"key":"ref_88","first-page":"1","article-title":"Oropharyngeal Candidiasis in HIV\/AIDS Patients and Non-HIV Subjects in the Southeast of Iran","volume":"4","author":"Pour","year":"2018","journal-title":"Curr. Med. Mycol."},{"key":"ref_89","first-page":"107","article-title":"Oral Candidiasis as a Local Adverse Effect of Inhaled Corticosteroids: What the Dental Practitioner Should Know","volume":"5","year":"2021","journal-title":"Black Sea J. Health Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Vila, T., Sultan, A.S., Montelongo-Jauregui, D., and Jabra-Rizk, M.A. (2020). Oral Candidiasis: A Disease of Opportunity. J. Fungi, 6.","DOI":"10.3390\/jof6010015"},{"key":"ref_91","first-page":"26512","article-title":"Impact of Asthma on Oral Health: A Review","volume":"9","author":"Sharma","year":"2018","journal-title":"Int. J. Recent. Sci. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e053133","DOI":"10.1136\/bmjopen-2021-053133","article-title":"Diseases with Oral Manifestations among Adult Asthmatics in Finland: A Population-Based Matched Cohort Study","volume":"11","author":"Lemmetyinen","year":"2021","journal-title":"BMJ Open"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Cuenca-Le\u00f3n, K., Pacheco-Quito, E.M., Granda-Granda, Y., V\u00e9lez-Le\u00f3n, E., and Zarzuelo-Casta\u00f1eda, A. (2022). Phytotherapy: A Solution to Decrease Antifungal Resistance in the Dental Field. Biomolecules, 12.","DOI":"10.3390\/biom12060789"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lfs.2019.03.005","article-title":"Is There an Association between Asthma and Periodontal Disease among Adults? Systematic Review and Meta-Analysis","volume":"223","author":"Ferreira","year":"2019","journal-title":"Life Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/odi.13228","article-title":"Periodontitis and Respiratory Diseases: A Systematic Review with Meta-Analysis","volume":"26","author":"Trindade","year":"2020","journal-title":"Oral Dis."},{"key":"ref_96","first-page":"47","article-title":"Association between Asthma and Periodontal Disease","volume":"5","author":"Yaghobee","year":"2018","journal-title":"Front. Dent. (J. Dent. Tehran Univ. Med. Sci.)"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1902\/jop.2017.170363","article-title":"Association Between Asthma and Periodontal Disease: A Systematic Review and Meta-Analysis","volume":"89","author":"Moraschini","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/jcpe.12553","article-title":"Relationship between Periodontal Disease and Asthma among Overweight\/Obese Adults","volume":"43","author":"Rivera","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_99","first-page":"e179","article-title":"Does Periodontal Infection Have an Effect on Severe Asthma in Adults?","volume":"85","author":"Trindade","year":"2014","journal-title":"J. Periodontol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Candeo, L.C., Rigonato-Oliveira, N.C., Brito, A.A., Marcos, R.L., Fran\u00e7a, C.M., Fernandes, K.P.S., Mesquita-Ferrari, R.A., Bussadori, S.K., Vieira, R.P., and Lino-Dos-Santos-Franco, A. (2017). Effects of Periodontitis on the Development of Asthma: The Role of Photodynamic Therapy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187945"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1902\/jop.2017.160414","article-title":"Risk of Periodontal Disease in Patients with Asthma: A Nationwide Population-Based Retrospective Cohort Study","volume":"88","author":"Shen","year":"2017","journal-title":"J. Periodontol."},{"key":"ref_102","first-page":"68","article-title":"Periodontal Disease Associated with Corticosteroid in Asthma Patients-A Systematic Review","volume":"11","author":"Mappangara","year":"2019","journal-title":"Int. J. Appl. Pharm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1834-7819.2010.01255.x","article-title":"A Literature Review of Dental Erosion in Children","volume":"55","author":"Taji","year":"2010","journal-title":"Aust. Dent. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3126\/kumj.v6i3.1714","article-title":"Asthma and Dental Erosion","volume":"6","author":"Manuel","year":"2008","journal-title":"Kathmandu Univ. Med. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5005\/johcd-3-3-56","article-title":"Dental Erosion in Children","volume":"3","author":"Gupta","year":"2009","journal-title":"J. Oral Health Comm. Dent."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000093360","article-title":"Dental Erosion in Children","volume":"20","author":"Lussi","year":"2006","journal-title":"Monogr. Oral Sci."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/5\/113\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:23:36Z","timestamp":1760124216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/5\/113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":106,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["dj11050113"],"URL":"https:\/\/doi.org\/10.3390\/dj11050113","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]}}}