{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:28:42Z","timestamp":1791239322860,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Dental caries management consists of both preventive and restorative approaches. Pediatric dentists can rely on many techniques and materials to restore decayed teeth, but a high failure rate is still observed, mainly due to secondary caries. New restorative bioactive materials combine the mechanical and aesthetic characteristics of resinous materials with the capability to remineralize and the antimicrobial properties of glass ionomers, thus counteracting the occurrence of secondary caries. The aim of this study was to assess the antimicrobial activity against Streptococcus mutans of a bioactive restorative material (ACTIVA\u2122 BioActive-Restorative\u2122-Pulpdent\u00a9) and a glass ionomer cement with silver particles added (Ketac\u2122 Silver\u20143M\u00a9), using agar diffusion assay. Methods: Each material was formed into disks of 4 mm in diameter, and four discs of each material were placed on nine agar plates. The analysis was repeated seven times. Results: Both materials showed statistically significant growth inhibition properties against S. mutans (p &lt; 0.05). The difference in the effectiveness of the two materials was not statistically significant. Conclusion: Both ACTIVA\u2122 and Ketac\u2122 Silver can be recommended since both are similarly effective against S. mutans. However ACTIVA\u2122, given its bioactivity and better aesthetics and mechanical properties compared to GICs, may provide better clinical performance.<\/jats:p>","DOI":"10.3390\/dj11060149","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T01:34:32Z","timestamp":1686188072000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of Antibacterial Activity of a Bioactive Restorative Material Versus a Glass-Ionomer Cement on Streptococcus Mutans: In-Vitro Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Giulio","family":"Conti","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, School of Dentistry, University of Insubria, Via Ravasi 2, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Veneri","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, Unit of Dentistry & Oral-Maxillo-Facial Surgery, University of Modena and Reggio Emilia, Via del Pozzo, 41124 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Amadori","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Pl. Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Garzoni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Pl. Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Majorana","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Pl. Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bardellini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Public Health, School of Pediatric Dentistry, University of Brescia, Pl. Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Skeie, M.S., Sen, A., Dahll\u00f6f, G., Fagerhaug, T.N., H\u00f8vik, H., and Klock, K.S. (2022). Dental Caries at Enamel and Dentine Level among European Adolescents\u2014A Systematic Review and Meta-Analysis. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02631-2"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15622","DOI":"10.1038\/s41598-020-72403-x","article-title":"Caries Severity and Socioeconomic Inequalities in a Nationwide Setting: Data from the Italian National Pathfinder in 12-Years Children","volume":"10","author":"Campus","year":"2020","journal-title":"Sci. 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