{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:21:40Z","timestamp":1760149300893,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Osteomyelitis of the jaws presents a clinical challenge to conventional treatment, often requiring multiple surgical interventions resulting in significant deformity and presenting significant problems to satisfactory rehabilitation. While benign odontogenic cysts, such as the radicular cyst, are generally predictably treated, they can cause significant localized bone destruction and thus can present significant problems in satisfactory rehabilitation. In this case report, patients were treated combining conventionally appropriate surgical debridement and oral antibiotics with adjunctive plasma rich in growth factors (PRGF). Patients showed a complete soft tissue and osseous regeneration to their pre-pathologic state, with successful implant rehabilitation. PRGF appears to be highly successful in minimizing or eliminating osseous deformities normally associated with conventional treatment of osteomyelitis of the jaw and treatment of large odontogenic cysts. Future trials must be performed to confirm these results in comparison to controls using conventional treatment alone.<\/jats:p>","DOI":"10.3390\/dj11080184","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T09:22:38Z","timestamp":1690795358000},"page":"184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adjunctive Plasma Rich in Growth Factors in the Treatment of Osteomyelitis and Large Odontogenic Cysts Prior to Successful Implant Rehabilitation: Case Report"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0735-8549","authenticated-orcid":false,"given":"Marc","family":"DuVal","sequence":"first","affiliation":[{"name":"Department of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada"},{"name":"Montreal Jewish General Hospital, Department of Dentistry and Oral and Oral and Maxillofacial Surgery, Montreal, QC H3T 1E2, Canada"},{"name":"Santa Cabrini Hospital, Department of Surgery, Division of Plastics, Montreal, QC H1T 1P7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-4527","authenticated-orcid":false,"given":"Mohammad Hamdan","family":"Alkhraisat","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.bjid.2013.12.005","article-title":"Recommendations for the treatment of osteomyelitis","volume":"18","author":"Lima","year":"2014","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0278-2391(10)80131-4","article-title":"Osteomyelitis of the jaws: A 50-year perspective","volume":"51","author":"Hudson","year":"1993","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0300-9785(84)80063-0","article-title":"Hyperbaric oxygen treatment of chronic osteomyelitis of the jaws","volume":"13","author":"Bakker","year":"1984","journal-title":"Int. J. Oral Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.oooo.2019.11.010","article-title":"Diffuse sclerosing osteomyelitis: A case series and literature review","volume":"129","author":"Matharu","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bjoms.2020.01.012","article-title":"Outcome of different treatments for chronic diffuse sclerosing osteomyelitis of the mandible: A systematic review of published papers","volume":"58","author":"Pichardo","year":"2020","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"D\u2019Agostino, S., Valentini, G., Dolci, M., and Ferrara, E. (2023). Potential Relationship between Poor Oral Hygiene and MRONJ: An Observational Retrospective Study. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20075402"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.oraloncology.2018.08.003","article-title":"Risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: A systematic review with meta-analyses","volume":"85","author":"Karna","year":"2018","journal-title":"Oral Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","article-title":"American Association of Oral and Maxillofacial Surgeons\u2019 Position. Paper on Medication-Related Osteonecrosis of the Jaws\u20142022 Update","volume":"80","author":"Ruggiero","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tempesta, A., Capodiferro, S., Di Nanna, S., D\u2019Agostino, S., Dolci, M., Scarano, A., Gambarini, G., Maiorano, E., Favia, G., and Limongelli, L. (2022). Medication-related osteonecrosis of the jaw triggered by endodontic failure in oncologic patients. Oral Dis.","DOI":"10.1111\/odi.14449"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s12663-021-01607-z","article-title":"Osteomyelitis of Maxilla: A Rare Presentation Yet Not So Rare","volume":"21","author":"Lata","year":"2022","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.joms.2022.03.012","article-title":"Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions?","volume":"80","author":"He","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"177S","DOI":"10.1097\/PRS.0b013e3182001f0f","article-title":"Treating osteomyelitis: Antibiotics and surgery","volume":"127","author":"Rao","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00002281-199407000-00009","article-title":"Osteomyelitis","volume":"6","author":"Laughlin","year":"1994","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.idc.2017.01.010","article-title":"Osteomyelitis","volume":"31","author":"Schmitt","year":"2017","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00084-17","DOI":"10.1128\/CMR.00084-17","article-title":"Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions","volume":"31","author":"Kavanagh","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/cir842","article-title":"Systemic antibiotic therapy for chronic osteomyelitis in adults","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0030-4220(92)90373-X","article-title":"Retrospective assessment of osteomyelitis: Etiology, demographics, risk factors, and management in 35 cases","volume":"74","author":"Koorbusch","year":"1992","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10006-009-0151-y","article-title":"Maxillomandibular osteomyelitis in osteopetrosis. Report of a case and review of the literature","volume":"13","author":"Vazquez","year":"2009","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijom.2012.03.019","article-title":"Hemimandibulectomy and vascularized fibula flap in bisphosphonate-induced mandibular osteonecrosis with polycythaemia rubra vera","volume":"42","author":"Ghazali","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2011.07.004","article-title":"Perspectives and challenges in regenerative medicine using plasma rich in growth factors","volume":"157","author":"Anitua","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"151853","DOI":"10.1016\/j.aanat.2021.151853","article-title":"The inclusion of leukocytes into platelet rich plasma reduces scaffold stability and hinders extracellular matrix remodelling","volume":"240","author":"Anitua","year":"2022","journal-title":"Ann. Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.transci.2008.01.006","article-title":"Treatment of chronic femoral osteomyelitis with platelet-rich plasma (PRP): A case report","volume":"38","author":"Yuan","year":"2008","journal-title":"Transfus. Apher. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tripleo.2007.07.039","article-title":"Improved treatment of mandibular odontogenic cysts with platelet-rich gel","volume":"105","author":"Bielecki","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_24","first-page":"833","article-title":"Successful management of spontaneous bone regeneration after jaws cystectomy using PRGF approach; case series","volume":"61","author":"Cavalu","year":"2020","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.path.2016.10.006","article-title":"Odontogenic Cysts and Neoplasms","volume":"10","author":"Bilodeau","year":"2017","journal-title":"Surg. Pathol. Clin."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"bcr2014203678","DOI":"10.1136\/bcr-2014-203678","article-title":"Giant radicular cyst of the maxilla","volume":"2014","author":"Deshmukh","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2298\/VSP1504372M","article-title":"Treatment of a large radicular cyst-enucleation or decompression?","volume":"72","author":"Matijevic","year":"2015","journal-title":"Vojnosanit. Pregl."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.joen.2018.12.014","article-title":"Management of Large Radicular Lesions Using Decompression: A Case Series and Review of the Literature","volume":"45","author":"Tian","year":"2019","journal-title":"J. Endod."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e13529","DOI":"10.1097\/MD.0000000000013529","article-title":"Pathological fracture of the mandible caused by radicular cyst: A case report and literature review","volume":"97","author":"Xiao","year":"2018","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1001\/archotol.1988.01860220091031","article-title":"Osteomyelitis of the mandible","volume":"114","author":"Calhoun","year":"1988","journal-title":"Arch. Otolaryngol. Head. Neck Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.joms.2019.01.036","article-title":"Management of Mandibular Osteomyelitis with Segmental Resection, Nerve Preservation, and Immediate Reconstruction","volume":"77","author":"Marschall","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e658","DOI":"10.1097\/SCS.0000000000005725","article-title":"Surgical Management of Large Odontogenic Cysts of the Mandible","volume":"30","author":"Bonavolonta","year":"2019","journal-title":"J. Craniofacial Surg."},{"key":"ref_33","first-page":"c59","article-title":"Management of a deeply impacted mandibular third molar and associated large dentigerous cyst to avoid nerve injury and improve periodontal healing: Case report","volume":"78","author":"Montevecchi","year":"2012","journal-title":"J. Can. Dent. Assoc."},{"key":"ref_34","first-page":"529","article-title":"Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants","volume":"14","author":"Anitua","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00784-014-1278-2","article-title":"Clinical, radiographical, and histological outcomes of plasma rich in growth factors in extraction socket: A randomized controlled clinical trial","volume":"19","author":"Anitua","year":"2015","journal-title":"Clin. Oral Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1902\/jop.2012.120292","article-title":"Plasma rich in growth factors promotes bone tissue regeneration by stimulating proliferation, migration, and autocrine secretion in primary human osteoblasts","volume":"84","author":"Anitua","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"151578","DOI":"10.1016\/j.aanat.2020.151578","article-title":"The influence of alveolar bone healing degree on its potential as a source of human alveolar bone-derived cells","volume":"232","author":"Anitua","year":"2020","journal-title":"Ann. Anat."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2217\/rme-2019-0123","article-title":"Bone regeneration in rabbit calvarial defects using PRGF and adipose-derived stem cells: Histomorphometrical analysis","volume":"15","author":"Stumbras","year":"2020","journal-title":"Regen. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/cid.12950","article-title":"Three-dimensional analysis of dimensional changes after alveolar ridge preservation with bone substitutes or plasma rich in growth factors: Randomized and controlled clinical trial","volume":"23","author":"Stumbras","year":"2021","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Anitua, E., Allende, M., and Alkhraisat, M.H. (2022). Unravelling Alveolar Bone Regeneration Ability of Platelet-Rich Plasma: A Systematic Review with Meta-Analysis. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100506"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Anitua, E., Allende, M., Eguia, A., and Alkhraisat, M.H. (2022). Bone-Regenerative Ability of Platelet-Rich Plasma Following Sinus Augmentation with Anorganic Bovine Bone: A Systematic Review with Meta-Analysis. Bioengineering, 9.","DOI":"10.3390\/bioengineering9100597"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2015.01.029","article-title":"Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia","volume":"202","author":"Anitua","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1563\/aaid-joi-D-19-00179","article-title":"Randomized and Controlled Clinical Trial of Bone Healing after Alveolar Ridge Preservation Using Xenografts and Allografts Versus Plasma Rich in Growth Factors","volume":"46","author":"Stumbras","year":"2020","journal-title":"J. Oral Implantol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000152915","article-title":"Osteonecrosis of the jaw: An update and review of recommendations","volume":"189","author":"Novince","year":"2009","journal-title":"Cells Tissues Organs"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00256-008-0549-x","article-title":"Osteonecrosis of the jaw","volume":"38","author":"Reid","year":"2009","journal-title":"Skelet. Radiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1158\/1078-0432.CCR-07-0551","article-title":"Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients","volume":"13","author":"Santini","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/annonc\/mdg194","article-title":"Bisphosphonates: New antiangiogenic molecules in cancer treatment?","volume":"14","author":"Vincenzi","year":"2003","journal-title":"Ann. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000518994","article-title":"The Effectiveness of Platelet-Rich Plasma as a Carrier of Stem Cells in Tissue Regeneration: A Systematic Review of Pre-Clinical Research","volume":"210","author":"Anitua","year":"2021","journal-title":"Cells Tissues Organs"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2217\/rme-2018-0066","article-title":"Autologous plasma rich in growth factors technology for isolation and ex vivo expansion of human dental pulp stem cells for clinical translation","volume":"14","author":"Anitua","year":"2019","journal-title":"Regen. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Anitua, E., Zalduendo, M., Troya, M., Alkhraisat, M.H., and Blanco-Antona, L.A. (2022). Platelet-Rich Plasma as an Alternative to Xenogeneic Sera in Cell-Based Therapies: A Need for Standardization. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126552"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00784-015-1528-y","article-title":"PRGF exerts a cytoprotective role in zoledronic acid-treated oral cells","volume":"20","author":"Anitua","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/cid.12171","article-title":"Plasma Rich in Growth Factors Improves Patients\u2019 Postoperative Quality of Life in Maxillary Sinus Floor Augmentation: Preliminary Results of a Randomized Clinical Study","volume":"17","author":"Corbella","year":"2015","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1016\/j.bjoms.2012.08.018","article-title":"Treatment of hemimandibular paresthesia in a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) by combining surgical resection and PRGF-Endoret","volume":"51","author":"Anitua","year":"2013","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1563\/aaid-joi-D-18-00254","article-title":"Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Plasma Rich in Growth Factors After Dental Implant Surgery: A Case Report","volume":"45","author":"Gil","year":"2019","journal-title":"J. Oral Implantol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100208","DOI":"10.1016\/j.bonr.2019.100208","article-title":"Three-dimensional bone evaluation after surgical treatment with plasma rich in growth factors of Medication Related Osteonecrosis of the Jaw (MRONJ): A report of 3 cases","volume":"10","author":"Iocca","year":"2019","journal-title":"Bone Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jbspin.2011.04.017","article-title":"A dental extraction protocol with plasma rich in growth factors (PRGF) in patients on intravenous bisphosphonate therapy: A case-control study","volume":"78","author":"Mozzati","year":"2011","journal-title":"Jt. Bone Spine"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.oraloncology.2011.12.004","article-title":"Platelet-rich therapies in the treatment of intravenous bisphosphonate-related osteonecrosis of the jaw: A report of 32 cases","volume":"48","author":"Mozzati","year":"2012","journal-title":"Oral Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Drago, L., Bortolin, M., Vassena, C., Romano, C.L., Taschieri, S., and Del Fabbro, M. (2014). Plasma components and platelet activation are essential for the antimicrobial properties of autologous platelet-rich plasma: An in vitro study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107813"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1365-2230.2011.04303.x","article-title":"Antibacterial effect of plasma rich in growth factors (PRGF(R)-Endoret(R)) against Staphylococcus aureus and Staphylococcus epidermidis strains","volume":"37","author":"Anitua","year":"2012","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Drago, L., Bortolin, M., Vassena, C., Taschieri, S., and Del Fabbro, M. (2013). Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity. BMC Microbiol., 13.","DOI":"10.1186\/1471-2180-13-47"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"250","DOI":"10.4103\/0974-8237.193260","article-title":"Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors reduce pain in patients with chronic low back pain","volume":"7","author":"Kirchner","year":"2016","journal-title":"J. Craniovertebr Junction Spine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s00167-013-2479-y","article-title":"Ultrasound-guided platelet-rich plasma injections for the treatment of common peroneal nerve palsy associated with multiple ligament injuries of the knee","volume":"22","author":"Sanchez","year":"2014","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_63","unstructured":"Atala, A., Lanza, R., Thomson, J., and Nerem, R. (2010). Foundations of Regenerative Medicines: Clinical and Therapeutic Applications, Academic Press."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/term.2079","article-title":"Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury","volume":"11","author":"Sanchez","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-2008-1076752","article-title":"Effect of platelet-rich plasma on peripheral nerve regeneration","volume":"24","author":"Sariguney","year":"2008","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1097\/WNR.0b013e3283567196","article-title":"Human platelet-rich plasma promotes axon growth in brain-spinal cord coculture","volume":"23","author":"Takeuchi","year":"2012","journal-title":"Neuroreport"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1111\/j.1743-6109.2012.02881.x","article-title":"The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model","volume":"9","author":"Wu","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_68","first-page":"2286","article-title":"Platelet-rich plasma gel in combination with Schwann cells for repair of sciatic nerve injury","volume":"7","author":"Ye","year":"2012","journal-title":"Neural Regen. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"47","DOI":"10.4103\/1673-5374.198973","article-title":"Platelet-rich plasma, an adjuvant biological therapy to assist peripheral nerve repair","volume":"12","author":"Sanchez","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1823.e1","DOI":"10.1016\/j.joms.2018.04.012","article-title":"Comparison of the Regenerative Effects of Platelet-Rich Fibrin and Plasma Rich in Growth Factors on Injured Peripheral Nerve: An Experimental Study","volume":"76","author":"Torul","year":"2018","journal-title":"J. Oral Maxillofac. Surg."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/8\/184\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:22:55Z","timestamp":1760127775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/8\/184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["dj11080184"],"URL":"https:\/\/doi.org\/10.3390\/dj11080184","relation":{},"ISSN":["2304-6767"],"issn-type":[{"type":"electronic","value":"2304-6767"}],"subject":[],"published":{"date-parts":[[2023,7,31]]}}}