{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:50:57Z","timestamp":1778694657760,"version":"3.51.4"},"reference-count":85,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>After tooth extraction, the alveolar ridge undergoes a physiological process of remodelling and disuse atrophy. Socket augmentation (SA) has been shown to preserve alveolar bone volume in order to facilitate implant placement and reduce the need for staged grafting at a later date. Although autogenic grafting has been shown to be the gold standard in bone regeneration, it has significant disadvantages. To prevent post-extraction volumetric alterations and alveolar bone resorption occurring, alternative grafting materials, including xenografts, alloplasts, and allografts, have been used successfully in fresh extraction sites. However, these materials act mostly as bio-scaffolds and require a slower integration period of 6\u20138 months prior to implant placement. Recently, the use of autologous platelet-rich fibrin (PRF) has been advocated alongside socket augmentation as a method of bio-enhancement of healing of soft and hard tissues. PRF contains platelet-derived growth factors, hormones, and bioactive components such as cytokines that have been shown to promote angiogenesis and tissue regeneration during wound healing. The aim of this article is to review the evidence base for the SA technique Clinical benefits of SA will be discussed with a reference to two cases. Therefore, this narrative review will discuss the post-extraction bone changes, the importance of SA, and the bio-enhancement role of PRF in the management of extraction site defects when the alternative technique of immediate implant placement is not possible or contraindicated.<\/jats:p>","DOI":"10.3390\/dj11080196","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:20:14Z","timestamp":1692008414000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extraction Socket Augmentation with Autologous Platelet-Rich Fibrin (PRF): The Rationale for Socket Augmentation"],"prefix":"10.3390","volume":"11","author":[{"given":"Cemal","family":"Ucer","sequence":"first","affiliation":[{"name":"I.C.E Postgraduate Dental Institute and Hospital, University of Salford, Salford M5 4WT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-5248","authenticated-orcid":false,"given":"Rabia S.","family":"Khan","sequence":"additional","affiliation":[{"name":"I.C.E Postgraduate Dental Institute and Hospital, University of Salford, Salford M5 4WT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1834-7819.1969.tb06001.x","article-title":"A study of the dimensional changes occurring in the maxilla following tooth extraction","volume":"14","author":"Johnson","year":"1969","journal-title":"Aust. Dent. J."},{"key":"ref_2","first-page":"1958","article-title":"Influence of PRF in the healing of bone and gingival tissues","volume":"17","author":"Marrelli","year":"2013","journal-title":"Clin. Histol. Eval. Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1902\/jop.2003.74.7.990","article-title":"Ridge preservation with freeze dried bone allograft and a membrane compared to extraction alone for implant site preparation: A clinical and histological study in humans","volume":"74","author":"Isalla","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1111\/cid.12182","article-title":"Influence of periodontal biotype on buccal bone remodeling after tooth extraction using the flapless approach with a xenograft: A histomorphometric and fluorescence study in small dogs","volume":"17","author":"Maia","year":"2015","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/prd.12167","article-title":"Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites","volume":"73","author":"Chappuis","year":"2017","journal-title":"Periodontology 2000"},{"key":"ref_6","first-page":"12","article-title":"Immediate or early placement of implants following tooth extraction: Review of biologic basis, clinical procedures, and outcomes","volume":"19","author":"Chen","year":"2004","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_7","first-page":"CD010176","article-title":"Interventions for replacing missing teeth: Alveolar ridge preservation techniques for dental implant site development","volume":"4","author":"Atieh","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/jcpe.13131","article-title":"Management of the extraction socket and timing of implant placement: Consensus report and clinical recommendations of group 3 of the XV European Workshop in Periodontology","volume":"46","author":"Tonetti","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"9352130","DOI":"10.1155\/2018\/9352130","article-title":"Efficacy of Alveolar Ridge Preservation after Maxillary Molar Extraction in Reducing Crestal Bone Resorption and Sinus Pneumatization: A Multicenter Prospective Case-Control Study","volume":"2018","author":"Lombardi","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_10","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study","volume":"23","author":"Schropp","year":"2003","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1631\/jzus.B1400119","article-title":"Contour changes in human alveolar bone following tooth extraction of the maxillary central incisor","volume":"15","author":"Li","year":"2014","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-051X.2005.00642.x","article-title":"Dimensional ridge alterations following tooth extraction","volume":"32","author":"Lindhe","year":"2005","journal-title":"Exp. Study Dog. J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdsr.2022.02.003","article-title":"The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies","volume":"58","author":"Farshidfar","year":"2022","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/jcpe.12612","article-title":"The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: A split-mouth, randomized, controlled clinical trial","volume":"43","author":"Temmerman","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/jcpe.13463","article-title":"Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: A split-mouth randomized controlled clinical trial","volume":"48","author":"Castro","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40729-021-00393-0","article-title":"Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: A systematic review","volume":"7","author":"Becker","year":"2021","journal-title":"Int. J. Implant Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"195S","DOI":"10.1177\/0022034513506713","article-title":"Ridge alterations post-extraction in the esthetic zone: A 3D analysis with CBCT","volume":"92","author":"Chappuis","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1177\/0022034514541127","article-title":"Effect of alveolar ridge preservation after tooth extraction: A systematic review and meta-analysis","volume":"93","author":"Elangovan","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/0022034520905660","article-title":"Efficacy of Alveolar Ridge Preservation: A Randomized Controlled Trial","volume":"99","author":"Gubler","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/clr.12639","article-title":"Does ridge preservation following tooth extraction improve implant treatment outcomes: A systematic review: Group 4: Therapeutic concepts & methods","volume":"26","author":"Mardas","year":"2015","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1600-0501.2010.01918.x","article-title":"Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: A randomized, controlled clinical trial","volume":"21","author":"Mardas","year":"2010","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/clr.12288","article-title":"Alveolar ridge preservation techniques: A systematic review and meta-analysis of histological and histomorphometrical data","volume":"26","author":"Clementini","year":"2015","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_23","first-page":"1109","article-title":"A retrospective analysis of patients referred for implant placement to a specialty clinic: Indications, surgical procedures, and early failures","volume":"23","author":"Bornstein","year":"2008","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1902\/jop.2014.140483","article-title":"Histologic healing following tooth extraction with ridge preservation using mineralized versus combined mineralized-demineralized freeze-dried bone allograft: A randomized controlled clinical trial","volume":"86","author":"Borg","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/cid.12490","article-title":"Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans","volume":"19","author":"Lang","year":"2017","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.11607\/jomi.2678","article-title":"Immediate placement of tapered effect (TE) implants: 5-year results of a prospective, multicenter study","volume":"28","author":"Wilson","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_27","first-page":"562","article-title":"A prospective randomized clinical study of changes in soft tissue position following immediate and delayed implant placement","volume":"25","author":"Schoolfield","year":"2010","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/clr.13796","article-title":"Early implant placement with or without alveolar ridge preservation in single tooth gaps renders similar esthetic, clinical and patient-reported outcome measures: One-year results of a randomized clinical trial","volume":"32","author":"Jonker","year":"2021","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.11613\/BM.2012.006","article-title":"Inflammation and haemostasis","volume":"22","author":"Margetic","year":"2012","journal-title":"Biochem. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.5005\/jp-journals-10024-2673","article-title":"Efficacy of PRF vs PRF + biodegradable collagen plug in post-extraction preservation of socket","volume":"20","author":"Ahmed","year":"2019","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jds.2016.06.007","article-title":"Effects of fibroblast growth factor-2 on cell proliferation of cementoblasts","volume":"11","author":"Yu","year":"2016","journal-title":"J. Dent. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zwittnig, K., Kirnbauer, B., Jakse, N., Schlenke, P., Mischak, I., Ghanaati, S., Al-Maawi, S., V\u00e9gh, D., Payer, M., and Zrnc, T.A. (2022). Growth Factor Release within Liquid and Solid PRF. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175070"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1600-0501.1997.080206.x","article-title":"Healing around implants placed in bone defects treated with Bio-Oss","volume":"8","author":"Berglundh","year":"1997","journal-title":"Exp. Study Dog. Clin. Oral Implant. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1034\/j.1600-0501.1999.100607.x","article-title":"The combined use of bioresorbable membranes and xenografts or autografts in the treatment of bone defects around implants. A study in beagle dogs","volume":"10","author":"Hockers","year":"1999","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1034\/j.1600-0501.1990.010104.x","article-title":"Regeneration and enlargement of jaw bone using guided tissue regeneration","volume":"1","author":"Buser","year":"1990","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/prd.12209","article-title":"Alveolar ridge preservation in the esthetic zone","volume":"77","author":"Jung","year":"2018","journal-title":"Periodontology 2000"},{"key":"ref_37","first-page":"6412806","article-title":"Alveolar Ridge Preservation Using a Novel Synthetic Grafting Material: A Case with Two-Year Follow-Up","volume":"2018","author":"Fairbairn","year":"2018","journal-title":"Case Rep. Dent."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Leventis, M., Tsetsenekou, E., and Kalyvas, D. (2020). Treatment of Osseous Defects after Mandibular Third Molar Removal with a Resorbable Alloplastic Grafting Material: A Case Series with 1- to 2-Year Follow-Up. Materials, 13.","DOI":"10.3390\/ma13204688"},{"key":"ref_39","first-page":"186","article-title":"Clinical and esthetic outcomes of implants placed in postextraction sites","volume":"24","author":"Chen","year":"2009","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_40","first-page":"77","article-title":"Dental extractions for patients on oral antiplatelet: A within-person randomised controlled trial comparing haemostatic plugs, advanced-platelet-rich fibrin (A-PRF+) plugs, leukocyte- and platelet-rich fibrin (L-PRF) plugs and suturing alone","volume":"12","author":"Giudice","year":"2019","journal-title":"Int. J. Oral Implantol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jcms.2020.02.020","article-title":"The use of leukocyte- and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial","volume":"48","author":"Javid","year":"2020","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jobcr.2020.06.012","article-title":"Influence of platelet-rich fibrin on wound healing and bone regeneration","volume":"10","author":"Sharma","year":"2020","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/ams.ams_153_17","article-title":"Wound healing and bone regeneration in postextraction sockets with and with- out platelet-rich fibrin","volume":"8","author":"Srinivas","year":"2018","journal-title":"Ann. Maxillofac. Surg."},{"key":"ref_44","first-page":"539","article-title":"Evaluation of diferent platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction","volume":"121","year":"2019","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"369273","DOI":"10.1155\/2015\/369273","article-title":"Influence of leukocyte- and platelet-rich fibrin (L-PRF) in the healing of simple postextraction sockets: A split-mouth study","volume":"2015","author":"Marenzi","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E794","DOI":"10.1097\/SCS.0000000000004818","article-title":"Novel application of platelet-rich fibrin as a wound healing enhancement in extraction sockets of patients who smoke","volume":"29","author":"Asmael","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1563\/AAID-JOI-09-00063","article-title":"Platelet rich plasma to facilitate wound healing following tooth extraction","volume":"36","author":"Rutkowski","year":"2010","journal-title":"J. Oral Implantol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/clr.13798","article-title":"Soft tissue management at implants: Summary and consensus statements of group 2. The 6th EAO Consensus Conference 2021","volume":"32","author":"Thoma","year":"2021","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/s41415-019-1000-5","article-title":"Factors affecting decision making at reassessment of periodontitis. Part 4: Treatment options for residual periodontal pockets","volume":"227","author":"Kalsi","year":"2019","journal-title":"Br. Dent. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"16036","DOI":"10.1038\/boneres.2016.36","article-title":"Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering","volume":"4","author":"Fernandes","year":"2016","journal-title":"Bone Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5051\/jpis.2005120256","article-title":"Compromised extraction sockets: A new classification and prevalence involving both soft and hard tissue loss","volume":"51","author":"Kim","year":"2021","journal-title":"J. Periodontal Implant Sci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pesce, P., Mijiritsky, E., Canullo, L., Menini, M., Caponio, V.C.A., Grassi, A., Gobbato, L., and Baldi, D. (2022). An Analysis of Different Techniques Used to Seal Post-Extractive Sites\u2014A Preliminary Report. Dent. J., 10.","DOI":"10.3390\/dj10100189"},{"key":"ref_53","first-page":"260","article-title":"Ridge preservation techniques for implant therapy","volume":"24","author":"Darby","year":"2009","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Pesce, P., Menini, M., Canullo, L., Khijmatgar, S., Modenese, L., Gallifante, G., and Del Fabbro, M. (2021). Radiographic and Histomorphometric Evaluation of Biomaterials Used for Lateral Sinus Augmentation: A Systematic Review on the Effect of Residual Bone Height and Vertical Graft Size on New Bone Formation and Graft Shrinkage. J. Clin. Med., 10.","DOI":"10.3390\/jcm10214996"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Canullo, L., Rossi-Fedele, G., Camodeca, F., Menini, M., and Pesce, P. (2021). A Pilot Retrospective Study on the Effect of Bone Grafting after Wisdom Teeth Extraction. Materials, 14.","DOI":"10.3390\/ma14112844"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ijom.2011.01.006","article-title":"Sinus floor elevation using osteotomes or piezoelectric surgery","volume":"40","author":"Baldi","year":"2011","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_57","first-page":"399","article-title":"Ridge preservation techniques to avoid invasive bone reconstruction: A systematic review and meta-analysis: Naples Consensus Report Working Group C","volume":"12","author":"Barootchi","year":"2019","journal-title":"Int. J. Oral Implantol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00784-012-0758-5","article-title":"Alveolar ridge preservation","volume":"17","author":"Mardas","year":"2013","journal-title":"Syst. Rev. Clin. Oral Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/ID.0000000000000920","article-title":"Radiological and Histomorphometric Outcomes of Homologous Bone Graft in Postextractive Implant Sites: A 6-Year Retrospective Analysis","volume":"28","author":"Baldi","year":"2019","journal-title":"Implant Dent."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1563\/aaid-joi-D-17-00179","article-title":"Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence?","volume":"44","author":"Ghanaati","year":"2018","journal-title":"J. Oral Implantol."},{"key":"ref_61","first-page":"108","article-title":"Extraction site bone grafting in general dentistry. Review of applications and principles","volume":"23","author":"Tischler","year":"2004","journal-title":"Dent. Today"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: A systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1902\/jop.1998.69.4.414","article-title":"Histologic findings after implantation and evaluation of different grafting materials and titanium micro screws into extraction sockets: Case reports","volume":"69","author":"Becker","year":"1998","journal-title":"J. Periodontol."},{"key":"ref_64","first-page":"19","article-title":"A study of the fate of the buccal wall of extraction sockets of teeth with prominent roots","volume":"26","author":"Nevins","year":"2006","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/clr.12366","article-title":"Ridge alterations following grafting of fresh extraction sockets in man","volume":"26","author":"Lindhe","year":"2015","journal-title":"Randomized Clin. Trial. Clin. Oral Implant. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41415-022-4967-2","article-title":"Is there clinical evidence to support alveolar ridge preservation over extraction alone? A review of recent literature and case reports of late graft failure","volume":"233","author":"Adams","year":"2022","journal-title":"Br. Dent. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.4103\/jpbs.JPBS_176_17","article-title":"Assessment of Regeneration of Bone in the Extracted Third Molar Sockets Augmented Using Xenograft (CollaPlugTN Zimmer) in Comparison with the Normal Healing on the Contralateral Side","volume":"9","author":"Ranganathan","year":"2017","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_68","first-page":"555","article-title":"Deproteinized bovine bone and biodegradable barrier membranes to support healing following immediate placement of transmucosal implants: A short-term controlled clinical trial","volume":"24","author":"Cornelini","year":"2004","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1600-0501.2007.01388.x","article-title":"A prospective clinical study of non-submerged immediate implants: Clinical outcomes and esthetic results","volume":"18","author":"Chen","year":"2007","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41415-019-0647-2","article-title":"Alveolar ridge preservation: Why, when and how","volume":"227","author":"Kalsi","year":"2019","journal-title":"Br. Dent. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1600-0501.2011.02386.x","article-title":"Clinical evaluation of a ridge augmentation procedure for the severely resorbed alveolar socket: Multicenter randomized controlled trial, preliminary results","volume":"23","author":"Sisti","year":"2012","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_72","first-page":"401","article-title":"A clinical and radiographical comparison of buccolingual crestal bone changes after immediate and delayed implant placement","volume":"92","author":"Amin","year":"2019","journal-title":"Med. Pharm. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bjoms.2019.07.019","article-title":"Does preservation of the socket decrease marginal bone loss in the mandible after extraction of first molars?","volume":"57","author":"Tabrizi","year":"2019","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.11607\/jomi.2670","article-title":"Surgical techniques for alveolar socket preservation: A systematic review","volume":"28","author":"Clementini","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5406736","DOI":"10.1155\/2016\/5406736","article-title":"Minimally Invasive Alveolar Ridge Preservation Utilizing an In Situ Hardening \u03b2-Tricalcium Phosphate Bone Substitute: A Multicenter Case Series","volume":"2016","author":"Leventis","year":"2016","journal-title":"Int. J. Dent."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/jcpe.13057","article-title":"Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta-analysis","volume":"46","author":"Chambrone","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1600-0501.2012.02535.x","article-title":"Tissue changes of extraction sockets in humans: A comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing","volume":"24","author":"Barone","year":"2013","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1600-0501.2011.02331.x","article-title":"Surgical protocols for ridge preservation after tooth extraction. A systematic review","volume":"23","author":"Vignoletti","year":"2012","journal-title":"Clin. Oral Implants Res."},{"key":"ref_79","first-page":"11","article-title":"Extraction site preservation using an in-situ hardening alloplastic bone graft substitute","volume":"35","author":"Leventis","year":"2014","journal-title":"Compend. Contin. Educ. Dent."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0501.2006.01320.x","article-title":"Comparison of naturally occurring and ligature-induced peri-implantitis bone defects in humans and dogs","volume":"18","author":"Schwarz","year":"2007","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_81","first-page":"614","article-title":"Ridge preservation and augmentation using regenerative materials to enhance implant predictability and esthetics","volume":"28","author":"Keith","year":"2007","journal-title":"Compend. Contin. Educ. Dent."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Yu, H.Y., and Chang, Y.C. (2022). A Bibliometric Analysis of Platelet-Rich Fibrin in Dentistry. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191912545"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/09537104.2017.1293807","article-title":"Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma","volume":"29","author":"Wang","year":"2018","journal-title":"Platelets"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.prosdent.2014.12.009","article-title":"Clinical and histologic outcomes of socket grafting after flapless tooth extraction: A systematic review of randomized controlled clinical trials","volume":"113","author":"Jambhekar","year":"2015","journal-title":"J. Prosthet. Dent."},{"key":"ref_85","unstructured":"Quirynen, M., and Pinto, N.R. (2022). Leukocyte- and Platelet-Rich Fibrin in Oral Regenerative Procedures: Evidence-Based Clinical Guidelines, Quintessenz Verlag."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/8\/196\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:33:24Z","timestamp":1760128404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/8\/196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":85,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["dj11080196"],"URL":"https:\/\/doi.org\/10.3390\/dj11080196","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]}}}