{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:15:24Z","timestamp":1789866924241,"version":"4.0.1"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Salivary duct carcinoma with rhabdoid features (SDC-RF) is a rare form of salivary gland neoplasm that was recently described. We report a case of SDC-RF of the parotid gland with loss of E-cadherin and decreased \u03b2-catenin expression in a 73-year-old male who presented with right facial\/neck swelling and intermittent pain. Morphologically, the tumor presented with a discohesive infiltrate of isolated and cords of pleomorphic round cells containing moderate amount of eosinophilic to fine-vacuolated cytoplasm and hyperchromatic nuclei infiltrating through fibroadipose tissue and salivary parenchyma. Immunophenotypically, the tumor was positive for Cytokeratins Oscar and 7, GATA3, GCDFP, HER2, and an androgen receptor but negative for CK20, S100, p40, Melan A, CDX2, TTF1, ER, SATB2, DOG1, synaptophysin, and chromogranin. Due to its diffuse infiltrating pattern, involvement of the parapharyngeal space, supraclavicular fat pad, dermis, and skin without a defined surgical target, the tumor was deemed unresectable. Anti-HER2 therapy (Herceptin and Pertuzumab) was utilized. At the last follow-up, the patient is alive, with complete locoregional control and brain metastases. An electronic search was performed in the following registries for papers published up to June 2023: PubMed, Embase, and Web of Science. For the database searches, the keywords searched were \u201csalivary gland\u201d, \u201csalivary duct carcinoma\u201d, and \u201csalivary duct carcinoma with rhabdoid features\u201d. Our review of the literature identified 30 cases of SDC-RF that reveal there is a predilection for males (83%), parotid gland (72%), and patients older than the 6th decade of life (83%). Immunophenotypically, all SDC-RF cases except one were positive for AR and GCDFP (97%), 81% were positive for HER2, and loss or decreased expression of E-cadherin in 93% of cases. In conclusion, we described a rare case of SDF-RF of the parotid gland with no E-cadherin expression, decreased \u03b2-catenin expression, and its immunophenotypic profile.<\/jats:p>","DOI":"10.3390\/dj11100229","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T03:56:49Z","timestamp":1695614209000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Salivary Duct Carcinoma with Rhabdoid Features of the Parotid Gland with No E-Cadherin Expression: A Report with Anti-HER2 Therapy and Review of the Literature"],"prefix":"10.3390","volume":"11","author":[{"given":"Richa","family":"Jain","sequence":"first","affiliation":[{"name":"Methodist Le Bonheur Healthcare, Memphis, TN 38104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ritter","family":"Sansoni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Angel","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Gleysteen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Neil","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-9469","authenticated-orcid":false,"given":"Adepitan A.","family":"Owosho","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"},{"name":"Department of Diagnostic Sciences, College of Dentistry, The University of Tennessee Health Science Center, Memphis, TN 38103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/BF00301495","article-title":"Salivary duct carcinoma. A group of salivary gland tumors analogous to mammary duct carcinoma","volume":"192","author":"Kleinsasser","year":"1968","journal-title":"Arch. Klin. Exp. Ohren Nasen Kehlkopfheilkd."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N","article-title":"Salivary duct carcinoma. Clinicopathologic and immunohistochemical review of 26 cases","volume":"77","author":"Lewis","year":"1996","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0046-8177(00)80221-X","article-title":"Sarcomatoid salivary duct carcinoma of the parotid gland","volume":"31","author":"Henley","year":"2000","journal-title":"Hum. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/00000478-200308000-00004","article-title":"Mucin-rich variant of salivary duct carcinoma: A clinicopathologic and immunohistochemical study of four cases","volume":"27","author":"Simpson","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00000478-200403000-00004","article-title":"Invasive micropapillary salivary duct carcinoma: A distinct histologic variant with biologic significance","volume":"28","author":"Nagao","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"152549","DOI":"10.1016\/j.prp.2019.152549","article-title":"Salivary duct carcinoma: A case report of oncocytic variant with possible treatment implications and review of literature","volume":"215","author":"Sekhri","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/PAS.0000000000000413","article-title":"Salivary duct carcinoma: The predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression","volume":"39","author":"Williams","year":"2015","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/PAS.0000000000001672","article-title":"Salivary Duct Carcinoma With Rhabdoid Features-No or Aberrant Expression of E-cadherin and Genetic Changes in CDH1: Immunohistochemical and Genetic Analyses of 17 Cases","volume":"45","author":"Kusafuka","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_9","first-page":"30","article-title":"Salivary Duct Carcinoma with Invasive Micropapillary and Rhabdoid Feature Arising in the Submandibular Gland","volume":"42","author":"Otsuru","year":"2017","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12105-020-01186-4","article-title":"Signet Ring Cell Differentiation in Salivary Duct Carcinoma with Rhabdoid Features: Report of Three Cases and Literature Review","volume":"15","author":"Akaki","year":"2021","journal-title":"Head Neck Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s12105-022-01464-3","article-title":"Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: Which phenotype should drive classification?","volume":"16","author":"Rooper","year":"2022","journal-title":"Head Neck Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1002\/hed.23466","article-title":"Salivary duct carcinoma with rhabdoid features: Report of 2 cases with immunohistochemical and ultrastructural analyses","volume":"36","author":"Kusafuka","year":"2014","journal-title":"Head Neck"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/his.12987","article-title":"Salivary duct carcinoma with rhabdoid features: A salivary counterpart of pleomorphic lobular carcinoma of the breast","volume":"70","author":"Kusafuka","year":"2017","journal-title":"Histopathology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1016\/j.clgc.2021.11.002","article-title":"Trends and Predictors of Hypofractionated and Intensity-Modulated Radiotherapy for Organ Preservation in Bladder Cancer","volume":"20","author":"Xiang","year":"2022","journal-title":"Clin. Genitourin. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12105-013-0442-3","article-title":"GATA3 immunohistochemical expression in salivary gland neoplasms","volume":"7","author":"Schwartz","year":"2013","journal-title":"Head Neck Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sisto, M., Ribatti, D., and Lisi, S. (2022). E-Cadherin Signaling in Salivary Gland Development and Autoimmunity. J. Clin. Med., 11.","DOI":"10.3390\/jcm11082241"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1158\/0008-5472.CAN-07-2938","article-title":"Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways","volume":"68","author":"Onder","year":"2008","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Burandt, E., Lubbersmeyer, F., Gorbokon, N., Buscheck, F., Luebke, A.M., Menz, A., Kluth, M., Hube-Magg, C., Hinsch, A., and Hoflmayer, D. (2021). E-Cadherin expression in human tumors: A tissue microarray study on 10,851 tumors. Biomark. Res., 9.","DOI":"10.1186\/s40364-021-00299-4"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14995","DOI":"10.1038\/s41598-020-72096-2","article-title":"Integrative genomic analysis of salivary duct carcinoma","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E1838","DOI":"10.1002\/hed.24332","article-title":"Salivary duct carcinoma: Clinicopathologic features, morphologic spectrum, and somatic mutations","volume":"38","author":"Luk","year":"2016","journal-title":"Head Neck"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/his.13759","article-title":"Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features","volume":"74","author":"Asahina","year":"2019","journal-title":"Histopathology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0000000000001591","article-title":"Molecular Profiling of Clear Cell Myoepithelial Carcinoma of Salivary Glands With EWSR1 Rearrangement Identifies Frequent PLAG1 Gene Fusions But No EWSR1 Fusion Transcripts","volume":"45","author":"Skalova","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41467-017-01178-z","article-title":"Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions","volume":"8","author":"Dalin","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0000000000000933","article-title":"Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common HRAS Mutations in PLAG1-intact and HMGA2-intact Cases, and Occasional TP53, FBXW7, and SMARCB1 Alterations in High-grade Cases","volume":"42","author":"Udager","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/gcc.22885","article-title":"Activation of PLAG1 and HMGA2 by gene fusions involving the transcriptional regulator gene NFIB","volume":"59","author":"Afshari","year":"2020","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/gcc.20619","article-title":"High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2","volume":"48","author":"Persson","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1097\/PAS.0000000000001280","article-title":"Metastasizing Pleomorphic Adenoma: Recurrent PLAG1\/HMGA2 Rearrangements and Identification of a Novel HMGA2-TMTC2 Fusion","volume":"43","author":"Wasserman","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"18740","DOI":"10.1073\/pnas.0909114106","article-title":"Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck","volume":"106","author":"Persson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1158\/2159-8290.CD-15-0859","article-title":"Recurrent Fusions in MYB and MYBL1 Define a Common, Transcription Factor-Driven Oncogenic Pathway in Salivary Gland Adenoid Cystic Carcinoma","volume":"6","author":"Brayer","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/modpathol.2009.126","article-title":"Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma","volume":"22","author":"Nakayama","year":"2009","journal-title":"Mod. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/gcc.22195","article-title":"Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin","volume":"53","author":"Weinreb","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ng.3096","article-title":"Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands","volume":"46","author":"Weinreb","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/PAS.0000000000001431","article-title":"Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study","volume":"44","author":"Xu","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neo.2021.03.008","article-title":"SalvGlandDx\u2014A comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets","volume":"23","author":"Freiberger","year":"2021","journal-title":"Neoplasia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/gcc.23122","article-title":"A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland","volume":"62","author":"Schuuring","year":"2023","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/gcc.23181","article-title":"A novel STRN3::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland with high-grade transformation","volume":"62","author":"Owosho","year":"2023","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/PAS.0b013e3181d9efcc","article-title":"Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity","volume":"34","author":"Skalova","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PAS.0000000000000972","article-title":"Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases","volume":"42","author":"Skalova","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/PAS.0000000000001065","article-title":"Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion: Expanding the Molecular Spectrum of a Recently Described Entity","volume":"42","author":"Rooper","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/PAS.0000000000001273","article-title":"Microsecretory Adenocarcinoma: A Novel Salivary Gland Tumor Characterized by a Recurrent MEF2C-SS18 Fusion","volume":"43","author":"Bishop","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/PAS.0000000000001301","article-title":"NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is \u201cIntraductal\u201d Correct?","volume":"43","author":"Skalova","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/his.14296","article-title":"Oncocytic intraductal carcinoma of salivary glands: A distinct variant with TRIM33-RET fusions and BRAF V600E mutations","volume":"79","author":"Bishop","year":"2021","journal-title":"Histopathology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/PAS.0000000000001200","article-title":"The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland","volume":"43","author":"Andreasen","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/PAS.0000000000001279","article-title":"Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands","volume":"43","author":"Haller","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41467-018-08069-x","article-title":"Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands","volume":"10","author":"Haller","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/PAS.0000000000001258","article-title":"Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum","volume":"43","author":"Urano","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1097\/PAS.0000000000001080","article-title":"Intraductal Papillary Mucinous Neoplasms of Minor Salivary Glands With AKT1 p.Glu17Lys Mutation","volume":"42","author":"Agaimy","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/PAS.0000000000001688","article-title":"Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations: Clinicopathologic and Molecular Characterization With Proposal for a Unified Classification","volume":"45","author":"Rooper","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/PAS.0000000000000669","article-title":"Distinctive Patterns of CTNNB1 (beta-Catenin) Alterations in Salivary Gland Basal Cell Adenoma and Basal Cell Adenocarcinoma","volume":"40","author":"Jo","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jfma.2017.11.011","article-title":"CTNNB1 mutations in basal cell adenoma of the salivary gland","volume":"117","author":"Lee","year":"2018","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s12105-019-01068-4","article-title":"Salivary Sialadenoma Papilliferum Consists of Two Morphologically, Immunophenotypically, and Genetically Distinct Subtypes","volume":"14","author":"Hsieh","year":"2020","journal-title":"Head Neck Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13000-021-01084-5","article-title":"Sialadenoma papilliferum: Clinicopathologic, Immunohistochemical, molecular analyses of new five cases and review of the literature","volume":"16","author":"Chen","year":"2021","journal-title":"Diagn. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Owosho, A.A., Shasteen, A.M., Aguirre, S.E., and Summersgill, K.F. (2023). Clinicopathologic Study of Sialadenoma Papilliferum of the Minor Salivary Glands: A Series of 8 New Cases With BRAF V600E Mutation-specific Immunohistochemical Analysis. Int. J. Surg. Pathol., 1\u20138.","DOI":"10.1177\/10668969221147170"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/hed.25035","article-title":"Androgen deprivation therapy for androgen receptor-positive advanced salivary duct carcinoma: A nationwide case series of 35 patients in The Netherlands","volume":"40","author":"Boon","year":"2018","journal-title":"Head Neck"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/cncr.33968","article-title":"Treatment patterns and outcomes of palliative systemic therapy in patients with salivary duct carcinoma and adenocarcinoma, not otherwise specified","volume":"128","author":"Sousa","year":"2022","journal-title":"Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/17588359221119538","article-title":"Survival benefit of HER2-targeted or androgen deprivation therapy in salivary duct carcinoma","volume":"14","author":"Kawakita","year":"2022","journal-title":"Ther. Adv. Med. Oncol."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/10\/229\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:57:24Z","timestamp":1760129844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/11\/10\/229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":56,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["dj11100229"],"URL":"https:\/\/doi.org\/10.3390\/dj11100229","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]}}}