{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:58:35Z","timestamp":1788353915316,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>The main objective of this prospective study was the evaluation of 1 mm step titration of mandible advancement in the success of treating obstructive sleep apnea (OSA). For that, a multicenter prospective study was designed to recruit patients with OSA who were eligible to receive a mandibular advancement device. Gradual titration of mandibular advancement (steps of 1 mm) from maximum intercuspidation was performed to determine the optimal mandibular advancement (highest reduction in the apnea-hypopnea index (AHI)). The principal variable was the percentage of patients where a reduction \u226550% of the AHI was achieved at the end of the titration phase. A total of 102 patients participated in this study. Fifty-six percent of the participants were males and 67% had a BMI \u2265 25 kg\/m2. Most of the patients (79%) had an age \u2265 50 years and the majority (74%) were either non-smokers or ex-smokers. Excessive daytime sleepiness was reported by 40% of the patients. The mean AHI at baseline was 20.6 \u00b1 12.7 events\/h. The mean advancement of the mandible was 3.1 \u00b1 1.6 mm. The device achieved a reduction in the AHI in 93% of the patients and success (\u226550% reduction in the AHI) in 69% of the patients. Success was achieved in 50%, 81.6%, and 73.3% of the patients with mild, moderate, and severe OSA, respectively. Decreasing the magnitude of mandibular advancement could be possible by controlling the vertical mouth opening and step-by-step titration.<\/jats:p>","DOI":"10.3390\/dj11110247","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:34:47Z","timestamp":1698147287000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Multicenter Prospective Study on the Use of a Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-5303","authenticated-orcid":false,"given":"Eduardo","family":"Anitua","sequence":"first","affiliation":[{"name":"Sleep Unit, Cl\u00ednica Eduardo Anitua, 01007 Vitoria, Spain"},{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-7301","authenticated-orcid":false,"given":"Pedro","family":"Mayoral","sequence":"additional","affiliation":[{"name":"Sleep Unit, Clinica Bisheimer, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Zamora","family":"Almeida","sequence":"additional","affiliation":[{"name":"Sleep Unit, Cl\u00ednica Eduardo Anitua, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Dur\u00e1n-Cantolla","sequence":"additional","affiliation":[{"name":"Sleep Unit, Cl\u00ednica Eduardo Anitua, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-4527","authenticated-orcid":false,"given":"Mohammad Hamdan","family":"Alkhraisat","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department, BTI Biotechnology Institute, 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Sleep Disorders Association (1995). 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