{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:59:02Z","timestamp":1791212342612,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>The goal of plastic periodontal surgery is to obtain complete root coverage, increasing gingival thickness (GT), a positive prognostic factor for gingival margin stability over time. The aim of this study was to compare the effectiveness of the Coronally Advanced Flap (CAF) in RT1 (GR; gingival recession with no loss of interproximal attachment) when associated with a connective tissue graft from the maxillary tuberosity (tCTG) or with leukocyte and platelet-rich fibrin (L-PRF) membranes in obtaining root coverage and increasing the thickness and width of the keratinized tissue, along with aesthetic improvement, taking into account a number of patient-related outcomes. Thirty patients with two adjacent RT1 GRs (GRs with no loss of interproximal attachment) were each treated using CAF associated with tCTG (15 patients) or L-PRF. The main outcome was a GT increase; secondary outcomes were keratinized tissue width (KT), gingival recession (GR), probing depth (PD), clinical attachment level (CAL), root coverage percentage (RC%), complete root coverage (CRC), and root coverage esthetic score (RES). Patient-reported outcomes were discomfort (D), dentine hypersensitivity (DH), patient-related esthetic score (PRES), and overall treatment satisfaction (OTS). After 12 months, clinical and patient-reported parameters did not show significant differences between groups, with the only exception being a GT gain, which was significantly greater in the CAF + tCTG group. Our results showed that both techniques were effective in treating RT1 GRs, with comparable patient-related outcomes. However, the use of tCTG produces significantly thicker tissue, covering the exposed root surface.<\/jats:p>","DOI":"10.3390\/dj12040086","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T13:20:53Z","timestamp":1711632053000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Multiple RT1 Gingival Recessions Using a Coronally Advanced Flap Associated with L-PRF or Subgingival Connective Tissue Graft from Maxillary Tuberosity: A Randomized, Controlled Clinical Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2760-8956","authenticated-orcid":false,"given":"Giuseppe","family":"Balice","sequence":"first","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Paolantonio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Serroni","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"De Ninis","sequence":"additional","affiliation":[{"name":"\u201cLuisa D\u2019Annunzio\u201d Institute for High Culture, Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-0556","authenticated-orcid":false,"given":"Imena","family":"Rexhepi","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Frisone","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Di Gregorio","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-3343","authenticated-orcid":false,"given":"Bruna","family":"Sinjari","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Murmura","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Femminella","sequence":"additional","affiliation":[{"name":"Department of Innovative Technologies in Medicine and Dentistry, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"ref_1","unstructured":"(2023, December 20). Glossary of Periodontal Terms\u2014AAP Connect. Available online: https:\/\/members.perio.org\/libraries\/glossary?ssopc=1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1902\/jop.1992.63.6.489","article-title":"The natural history of periodontal disease in man: Prevalence, severity, and extent of gingival recession","volume":"63","author":"Boysen","year":"1992","journal-title":"J. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-051X.1994.tb00278.x","article-title":"The prevalence and distribution of gingival recession in subjects with a high standard of oral hygiene","volume":"21","author":"Serino","year":"1994","journal-title":"J. Clin. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0528.1976.tb01607.x","article-title":"Prevalence of oral soft and hard tissue lesions related to mechanical toothcleansing procedures","volume":"4","author":"Sangnes","year":"1976","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1902\/jop.2007.060277","article-title":"The evolution of buccal gingival recessions in a student population: A 5-year follow-up","volume":"78","author":"Daprile","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1902\/jop.2009.090122","article-title":"Periodontal conditions of sites treated with gingival-augmentation surgery compared to untreated contralateral homologous sites: A 10- to 27-year long-term study","volume":"80","author":"Agudio","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1902\/jop.2016.150625","article-title":"Long-Term Outcomes of Untreated Buccal Gingival Recessions: A Systematic Review and Meta-Analysis","volume":"87","author":"Chambrone","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/prd.12059","article-title":"Periodontal plastic surgery","volume":"68","author":"Zucchelli","year":"2015","journal-title":"Periodontology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1111\/jcpe.12182","article-title":"Efficacy of periodontal plastic surgery procedures in the treatment of localized facial gingival recessions. A systematic review","volume":"41","author":"Cairo","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1111\/jcpe.12185","article-title":"The addition of soft tissue replacement grafts in plastic periodontal and implant surgery: Critical elements in design and execution","volume":"41","author":"Zuhr","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1902\/jop.2009.080565","article-title":"Root coverage esthetic score: A system to evaluate the esthetic outcome of the treatment of gingival recession through evaluation of clinical cases","volume":"80","author":"Cairo","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1902\/jop.2015.130674","article-title":"Periodontal soft tissue root coverage procedures: A systematic review from the AAP Regeneration Workshop","volume":"86","author":"Chambrone","year":"2015","journal-title":"J. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jcpe.12256","article-title":"Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial","volume":"41","author":"Zucchelli","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1975.tb00001.x","article-title":"The role of gingival connective tissue in determining epithelial differentiation","volume":"10","author":"Karring","year":"1975","journal-title":"J. Periodontal Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.11607\/prd.1929","article-title":"Human palatal and tuberosity mucosa as donor sites for ridge augmentation","volume":"34","author":"Dellavia","year":"2014","journal-title":"Int. J. Periodontics Restorative Dent."},{"key":"ref_16","first-page":"121","article-title":"Free autogenous gingival grafts. I. Principles of successful grafting","volume":"6","author":"Sullivan","year":"1968","journal-title":"Periodontics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00784-018-2516-9","article-title":"Structural and histological differences between connective tissue grafts harvested from the lateral palatal mucosa or from the tuberosity area","volume":"23","author":"Rojo","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1902\/jop.2008.070445","article-title":"Histologic observation of soft tissue acquired from maxillary tuberosity area for root coverage","volume":"79","author":"Jung","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1902\/jop.2001.72.11.1572","article-title":"Root coverage and pocket reduction as combined surgical procedures","volume":"72","author":"Hirsch","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/jcpe.13800","article-title":"Histological and histomorphometric study of human palatal mucosa: Implications for connective tissue graft harvesting","volume":"50","author":"Gallego","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41368-023-00260-1","article-title":"Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate","volume":"15","author":"Asparuhova","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"ref_22","first-page":"589","article-title":"Tuberosity versus palatal donor sites for soft tissue grafting: A split-mouth clinical study","volume":"49","author":"Amin","year":"2018","journal-title":"Quintessence Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.5005\/jp-journals-10024-3104","article-title":"Connective Tissue Graft vs Platelet-rich Fibrin in the Treatment of Gingival Recessions: A Randomized Split-mouth Case Series","volume":"22","author":"Collins","year":"2021","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1902\/jop.2009.080253","article-title":"Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: A 6-month study","volume":"80","author":"Aroca","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.4103\/0972-124X.119281","article-title":"A split mouth randomized controlled study to evaluate the adjunctive effect of platelet-rich fibrin to coronally advanced flap in Miller\u2019s class-I and II recession defects","volume":"17","author":"Padma","year":"2013","journal-title":"J. Indian. Soc. Periodontol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mancini, L., Tarallo, F., Quinzi, V., Fratini, A., Mummolo, S., and Marchetti, E. (2021). Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis. Medicina, 57.","DOI":"10.3390\/medicina57020144"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/JPER.22-0075","article-title":"Efficacy of biologics in root coverage and gingival augmentation therapy: An American Academy of Periodontology best evidence systematic review and network meta-analysis","volume":"93","author":"Chambrone","year":"2022","journal-title":"J. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00784-020-03400-7","article-title":"Use of platelet-rich fibrin for the treatment of gingival recessions: A systematic review and meta-analysis","volume":"24","author":"Miron","year":"2020","journal-title":"Clin Oral Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1007\/s00784-020-03547-3","article-title":"Effectiveness of connective tissue graft substitutes for the treatment of gingival recessions compared with coronally advanced flap: A network meta-analysis","volume":"24","author":"Moraschini","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jcpe.12643","article-title":"Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: Intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis","volume":"44","author":"Castro","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1002\/JPER.16-0671","article-title":"Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations","volume":"89","author":"Cortellini","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_32","first-page":"8A","article-title":"Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity","volume":"22","author":"Cummins","year":"2009","journal-title":"Am. J. Dent."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1902\/jop.1989.60.6.316","article-title":"Coronal positioning of existing gingiva: Short term results in the treatment of shallow marginal tissue recession","volume":"60","author":"Allen","year":"1989","journal-title":"J. Periodontol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/jcpe.13843","article-title":"Histological assessment and gene expression analysis of intra-oral soft tissue graft donor sites","volume":"50","author":"Stuhr","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/jcpe.13163","article-title":"Acellular dermal matrix and coronally advanced flap or tunnel technique in the treatment of multiple adjacent gingival recessions. A 12-year follow-up from a randomized clinical trial","volume":"46","author":"Tavelli","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/jcpe.13641","article-title":"Soft tissue phenotype modification predicts gingival margin long-term (10-year) stability: Longitudinal analysis of six randomized clinical trials","volume":"49","author":"Barootchi","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/jcpe.12254","article-title":"Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: A RCT using 3D digital measuring methods. Part II. Volumetric studies on healing dynamics and gingival dimensions","volume":"41","author":"Rebele","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/JPER.18-0615","article-title":"Is a soft tissue graft harvested from the maxillary tuberosity the approach of choice in an isolated site?","volume":"90","author":"Tavelli","year":"2019","journal-title":"J. Periodontol."},{"key":"ref_40","first-page":"e41","article-title":"Use of platelet-rich fibrin membrane following treatment of gingival recession: A randomized clinical trial","volume":"32","author":"Jankovic","year":"2012","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00784-017-2225-9","article-title":"Clinical evaluation of coronally advanced flap with or without platelet-rich fibrin for the treatment of multiple gingival recessions","volume":"22","author":"Kuka","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1902\/jop.2002.73.1.53","article-title":"Treatment of gingival recessions by combined periodontal regenerative technique, guided tissue regeneration, and subpedicle connective tissue graft. A comparative clinical study","volume":"73","author":"Paolantonio","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/jcpe.12224","article-title":"Coronally advanced flap with and without connective tissue graft for the treatment of multiple gingival recessions: A comparative short- and long-term controlled randomized clinical trial","volume":"41","author":"Zucchelli","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1007\/s00784-023-04944-0","article-title":"Gingival phenotype changes after different periodontal plastic surgical techniques: A single-masked randomized controlled clinical trial","volume":"27","author":"Santamaria","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1902\/jop.2009.090531","article-title":"Three-dimensional architecture and cell composition of a Choukroun\u2019s platelet-rich fibrin clot and membrane","volume":"81","author":"Ehrenfest","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/jcpe.12869","article-title":"Soft tissue volume gain around dental implants using autogenous subepithelial connective tissue grafts harvested from the lateral palate or tuberosity area. A randomized controlled clinical study","volume":"45","author":"Rojo","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cap.10047","article-title":"Hyperplastic Response Following Soft Tissue Augmentation in the Esthetic Zone","volume":"9","author":"Gluckman","year":"2019","journal-title":"Clin. Adv. Periodontics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/cre2.468","article-title":"Full versus partial thickness flap to determine differentiation and over keratinization of non-keratinized mucosa. A 3-year split mouth randomized pilot study","volume":"7","author":"Puisys","year":"2021","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1902\/jop.2015.150198","article-title":"Clinical Comparison of Platelet-Rich Fibrin and a Gelatin Sponge in the Management of Palatal Wounds After Epithelialized Free Gingival Graft Harvest: A Randomized Clinical Trial","volume":"87","author":"Femminella","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/jcpe.12590","article-title":"Clinical efficacy of coronally advanced flap with or without connective tissue graft for the treatment of multiple adjacent gingival recessions in the aesthetic area: A randomized controlled clinical trial","volume":"43","author":"Cairo","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/jcpe.12932","article-title":"Predictor factors for long-term outcomes stability of coronally advanced flap with or without connective tissue graft in the treatment of single maxillary gingival recessions: 9 years results of a randomized controlled clinical trial","volume":"45","author":"Rasperini","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12477","article-title":"Minimal invasiveness in gingival augmentation and root coverage procedures","volume":"91","author":"Cairo","year":"2023","journal-title":"Periodontology 2000"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/4\/86\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:20:23Z","timestamp":1760106023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/4\/86"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["dj12040086"],"URL":"https:\/\/doi.org\/10.3390\/dj12040086","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]}}}