{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:35:30Z","timestamp":1790361330889,"version":"4.1.0"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Caries and periodontitis are the most prevalent oral diseases worldwide. Major factors contributing to the development of these oral conditions include poor oral hygiene, dental biofilm formation, high carbohydrates diet, smoking, other systemic diseases, and genetic factors. Various preventive measures have been established to mitigate the risk of caries and periodontal disease development. The present review aims to discuss the role of the probiotics Lactobacillus rhamnosus and Lactobacillus plantarum in the prevention and treatment of caries and periodontal diseases. The study was conducted in accordance with PRISMA guidelines and was registered on PROSPERO. The search involved PubMed, Web of Science, and Scopus and considered the PICO format. Studies were screened by two reviewers independently, and disagreements were solved by consensus with a third reviewer. Data extraction included details about the type of probiotics, strains, and purpose of administration. A total of 15 RCTs were included, of which just 1 was about tooth cavities. Overall, 87% of the included studies were good-quality papers regarding the Jadad Scale. Several studies agreed on the potential of probiotics L. rhamnosus and L. plantarum, both alone and combined, to prevent and improve clinical outcomes in caries and periodontal treatments, weaker evidence is provided for the microbiological benefit.<\/jats:p>","DOI":"10.3390\/dj12040102","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:55:28Z","timestamp":1712746528000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-4768","authenticated-orcid":false,"given":"Silvia","family":"D\u2019Agostino","sequence":"first","affiliation":[{"name":"Complex Unit of Odontostomatology, Interdisciplinary Department of Medicine, University A. Moro, 70124 Bari, Italy"},{"name":"Department of Medical, Oral and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4051-6075","authenticated-orcid":false,"given":"Giulia","family":"Valentini","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Iarussi","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5495-5660","authenticated-orcid":false,"given":"Marco","family":"Dolci","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences, University G. d\u2019Annunzio, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"ref_1","unstructured":"(2023, November 25). World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/oral-health."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/10454411950060040401","article-title":"Genetic Influences in Caries and Periodontal Diseases","volume":"6","author":"Hassell","year":"1995","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_4","first-page":"257","article-title":"Caries Management by Risk Assessment: Consensus Statement, April 2002","volume":"31","author":"Featherstone","year":"2003","journal-title":"J. Calif. Dent. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1538-5442(03)00093-2","article-title":"Dental caries, oral health, and pediatricians","volume":"33","author":"Krol","year":"2003","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1745-7599.2008.00367.x","article-title":"Assessment, management, and prevention of early childhood caries","volume":"21","author":"Kagihara","year":"2009","journal-title":"J. Am. Acad. Nurse Pract."},{"key":"ref_7","unstructured":"Nassar, Y., and Brizuela, M. (2023). The Role of Fluoride on Caries Prevention, StatPearls Publishing."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1107\/S2053230X23003199","article-title":"The catalytic domains of Streptococcus mutans glucosyltransferases: A structural analysis","volume":"79","author":"Schormann","year":"2023","journal-title":"Acta Crystallogr. Sect. F Struct. Biol. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-051X.1990.tb01071.x","article-title":"Diagnostic predictability of scores of plaque, bleeding, suppuration and probing depth for probing attachment loss","volume":"17","author":"Claffey","year":"1990","journal-title":"J. Clin. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jagannathan, R., Balaji, T.M., Rao, S.R., Alosaimi, M.S., Patil, S., Siurkel, Y., Cicci\u00f9, M., and Minervini, G. (2024). Effect of non-surgical periodontal therapy on CD14+ CD16+ monocyte counts in peripheral blood samples: A clinical interventional study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-023-03793-3"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1902\/jop.1992.63.2.118","article-title":"Periodontal Response to Mechanical Non-Surgical Therapy: A Review","volume":"63","author":"Greenstein","year":"1992","journal-title":"J. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-051X.1997.tb00765.x","article-title":"The effect of SRP on the clinical and microbiological parameters of periodontal diseases","volume":"24","author":"Haffajee","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1902\/jop.1988.59.4.222","article-title":"Bacterial Invasion in Root Cementum and Radicular Dentin of Periodontally Diseased Teeth in Humans","volume":"59","author":"Adriaens","year":"1988","journal-title":"J. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1902\/jop.1987.58.8.529","article-title":"Tissue Localization of Actinobacillus actinomycetemcomitans in Human Periodontitis","volume":"58","author":"Christersson","year":"1987","journal-title":"J. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1902\/jop.1989.60.7.402","article-title":"Scaling and Root Planing Efficacy in Multirooted Teeth","volume":"60","author":"Fleischer","year":"1989","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Reyes, L., Getachew, H., Dunn, W., and Progulske-Fox, A. (2020). Porphyromonas gingivalis W83 traffics via ICAM1 in microvascular endothelial cells and alters capillary organization in vivo. J. Oral Microbiol., 12.","DOI":"10.1080\/20002297.2020.1742528"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1600-051X.1992.tb00460.x","article-title":"Non-surgical periodontal treatment: Where are the limits?","volume":"19","author":"Schwarz","year":"1992","journal-title":"J. Clin. Periodontol."},{"key":"ref_18","first-page":"488","article-title":"Probiotics\u2014Do they have a role in medicine and dentistry?","volume":"58","author":"Saraf","year":"2010","journal-title":"J. Assoc. Physicians India"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bdj.2016.865","article-title":"The oral microbiome\u2014An update for oral healthcare professionals","volume":"221","author":"Kilian","year":"2016","journal-title":"Br. Dent. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1159\/000047484","article-title":"Effect of Long\u2013Term Consumption of a Probiotic Bacterium, Lactobacillus rhamnosus GG, in Milk on Dental Caries and Caries Risk in Children","volume":"35","author":"Hatakka","year":"2001","journal-title":"Caries Res."},{"key":"ref_21","first-page":"482","article-title":"Probiotic characteristics of Lactobacilus plantarum HO-69 applied in oral cavity","volume":"26","author":"Yang","year":"2008","journal-title":"Huaxi Kouqiang Yixue Zazhi West China J. Stomatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/1678-775720150145","article-title":"Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuation","volume":"24","author":"Mendi","year":"2016","journal-title":"J. Appl. Oral Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.archoralbio.2011.10.006","article-title":"Isolation and characterization of probiotic strains for improving oral health","volume":"57","author":"Bosch","year":"2012","journal-title":"Arch. Oral Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"10","author":"Page","year":"2021","journal-title":"Syst. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control. Clin. Trials"},{"key":"ref_26","first-page":"372","article-title":"Effect of Lacticaseibacillus rhamnosus L8020 on the abundance of periodontal pathogens in individuals with intellectual disability: A randomized clinical trial","volume":"54","author":"Oda","year":"2023","journal-title":"Quintessence Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"104599","DOI":"10.1016\/j.jdent.2023.104599","article-title":"The effect of a lozenge combining prebiotic arginine and probiotics on caries increment in children during 10\u201312 months, a randomized clinical trial","volume":"135","author":"Keller","year":"2023","journal-title":"J. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/idh.12589","article-title":"Probiotic mouthwash as an adjunct to mechanical therapy in the treatment of stage II periodontitis: A randomized controlled clinical trial","volume":"20","author":"Ranjith","year":"2022","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/jcpe.13663","article-title":"Adjuvant use of multispecies probiotic in the treatment of peri-implant mucositis: A randomized controlled trial","volume":"49","author":"Santana","year":"2022","journal-title":"J. Clin. Periodontol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Morales, A., Contador, R., Bravo, J., Carvajal, P., Silva, N., Strauss, F.-J., and Gamonal, J. (2021). Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: A pilot randomized controlled clinical trial. BMC Oral Health, 21.","DOI":"10.1186\/s12903-020-01276-3"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00784-020-03449-4","article-title":"Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial","volume":"25","author":"Pudgar","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e20180564","DOI":"10.1590\/1678-7757-2018-0564","article-title":"Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: A randomized clinical trial","volume":"27","author":"Yuki","year":"2019","journal-title":"J. Appl. Oral Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3920\/BM2017.0139","article-title":"Effect of Lactobacillus rhamnosus and Bifidobacterium lactis on gingival health, dental plaque, and periodontopathogens in adolescents: A randomised placebo-controlled clinical trial","volume":"9","author":"Alanzi","year":"2018","journal-title":"Benef. Microbes"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e20170075","DOI":"10.1590\/1678-7757-2017-0075","article-title":"Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: A randomized placebo- controlled trial with 9-month follow-up","volume":"26","author":"Morales","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3920\/BM2017.0104","article-title":"Effect of tablets containing probiotic candidate strains on gingival inflammation and composition of the salivary microbiome: A randomised controlled trial","volume":"9","author":"Keller","year":"2018","journal-title":"Benef. Microbes"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/jcpe.12689","article-title":"Adjunctive efficacy of probiotics in the treatment of experimental peri-implant mucositis with mechanical and photodynamic therapy: A randomized, cross-over clinical trial","volume":"44","author":"Mongardini","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jcpe.12752","article-title":"Clinical and microbiological effects of the adjunctive use of probiotics in the treatment of gingivitis: A randomized controlled clinical trial","volume":"44","author":"Montero","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"ref_38","first-page":"207","article-title":"Daily Intake of Heat-killed Lactobacillus plantarum L-137 Decreases the Probing Depth in Patients Undergoing Supportive Periodontal Therapy","volume":"14","author":"Kazuto","year":"2016","journal-title":"Oral Health Prev. Dent."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1902\/jop.2016.150665","article-title":"Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial with 1-Year Follow-Up","volume":"87","author":"Morales","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00784-014-1221-6","article-title":"Impact of orally administered lozenges with Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 on the number of salivary mutans streptococci, amount of plaque, gingival inflammation and the oral microbiome in healthy adults","volume":"19","author":"Toiviainen","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/0022034512449465","article-title":"Probiotics for Caries Prevention and Control","volume":"24","author":"Twetman","year":"2012","journal-title":"Adv. Dent. Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Devine, D.A., Marsh, P.D., and Meade, J. (2015). Modulation of host responses by oral commensal bacteria. J. Oral Microbiol., 7.","DOI":"10.3402\/jom.v7.26941"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/4\/102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:25:54Z","timestamp":1760106354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/4\/102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["dj12040102"],"URL":"https:\/\/doi.org\/10.3390\/dj12040102","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]}}}