{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:26:26Z","timestamp":1782170786823,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Dental caries is a dynamic, multifactorial disease that destroys teeth and can affect anyone\u2019s quality of life because it can cause tooth loss and make chewing difficult. Dental caries involves various factors, such as Streptococcus mutans and host factors. Currently, adjuvant therapies, such as curcumin, have emerged, but how they work has not been adequately described. Therefore, this work aims to identify the molecular mechanism of curcumin in caries and Streptococcus mutans. Methods: We obtained differentially expressed genes from a GEO dataset, and curcumin targets were obtained from other databases. The common targets were analyzed according to gene ontology enrichment, key genes were obtained, and binding to curcumin was verified by molecular docking. Results: Our analysis showed that curcumin presents 134 therapeutic targets in caries. According to the gene ontology analysis, these targets are mainly involved in apoptosis and inflammation. There are seven key proteins involved in the action of curcumin on caries: MAPK1, BCL2, KRAS, CXCL8, TGFB1, MMP9, and IL1B, all of which spontaneously bind curcumin. In addition, curcumin affects metabolic pathways related to lipid, purine, and pyrimidine metabolism in Streptococcus mutans. Conclusions: Curcumin affects both host carious processes and Streptococcus mutans.<\/jats:p>","DOI":"10.3390\/dj12060153","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T06:54:09Z","timestamp":1716360849000},"page":"153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-112X","authenticated-orcid":false,"given":"Juan Manuel","family":"Guzm\u00e1n-Flores","sequence":"first","affiliation":[{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"P\u00e9rez-Reyes","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Isela","family":"V\u00e1zquez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-6866","authenticated-orcid":false,"given":"Mario Alberto","family":"Isiordia-Espinoza","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias M\u00e9dicas, Cuerpo Acad\u00e9mico Terap\u00e9utica y Biolog\u00eda Molecular (UDG-CA-973), Departamento de Cl\u00ednicas, Divisi\u00f3n de Ciencias Biom\u00e9dicas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-3153","authenticated-orcid":false,"given":"Fernando","family":"Mart\u00ednez-Esquivias","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Pecuarias y Agr\u00edcolas, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitl\u00e1n de Morelos 47620, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000503309","article-title":"Terminology of Dental Caries and Dental Caries Management: Consensus Report of a Workshop Organized by ORCA and Cariology Research Group of IADR","volume":"54","author":"Machiulskiene","year":"2020","journal-title":"Caries Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1570164620666230331102317","article-title":"Integration of Proteomic Data Obtained from the Saliva of Children with Caries through Bioinformatic Analysis","volume":"20","year":"2023","journal-title":"Curr. 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