{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:13:36Z","timestamp":1763644416574,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sunstar America, Inc.","award":["163272"],"award-info":[{"award-number":["163272"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>This study investigated the efficacy of Isomalt-containing toothpaste in preventing development of dental caries. Methods: Human dental enamel slabs were allocated to six groups (30\/group) at random: De-ionized distilled water (DDW), and toothpaste containing 10% Isomalt, 1100 ppm fluoride, 0.05% cetylpyridinium chloride [CPC] (ICT); 10% Isomalt, 1100 ppm fluoride (IT); 10% Isomalt, 1100 ppm fluoride, 1.5% Sodium lauryl sulfate [SLS] (IST); 1100 ppm fluoride only (FT); 1100 ppm fluoride with SLS (FST). The enamel slabs were exposed to caries development via plaque growth in a Microbial Caries Model for 7 days. Toothpastes were applied as slurries (one toothpaste\u2013three DDW) for 2 min twice daily. Demineralization was measured as the change in surface microhardness (\u0394SMH) and amount of mineral lost (\u2206Z), and these metrics were assessed using Transverse Microradiography. Intra-group (SMH) and intergroup (%\u2206SMH and \u2206Z) comparisons were paired t-test and Tukey\u2019s test (\u03b1 = 0.05), respectively. Results: With SMH, demineralization was found to be significant (p &lt; 0.001) in all groups compared to sound enamel baseline, except ICT group. With %\u0394SMH, all other groups had significantly (p &lt; 0.001) less demineralization compared to DDW. Significantly (p &lt; 0.001) greater demineralization was observed in IT, FT and FST compared to ICT, and no significant difference was observed between IST and ICT or FT. With \u2206Z, relative to the DDW group, the inhibition of demineralization was significant (p &lt; 0.0001) in all groups at varying percentages. Conclusions: Toothpaste containing 10% Isomalt, 1100 ppm fluoride, and 0.05% CPC demonstrated greater efficacy in inhibiting caries development amid dental plaque compared to toothpaste containing only 1100 ppm fluoride.<\/jats:p>","DOI":"10.3390\/dj12090290","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:23:43Z","timestamp":1726122223000},"page":"290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of New Isomalt-Containing Toothpaste Formulations in Preventing Dental Caries: A Microbial Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-4466","authenticated-orcid":false,"given":"Bennett Tochukwu","family":"Amaechi","sequence":"first","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parveez Ahamed","family":"Abdul Azees","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Camila","family":"Restrepo-Ceron","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"},{"name":"Department of Odontologia, School of Odontologa, CES University, Medell\u00edn 050001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitope Olabisi","family":"Omosebi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Lagos State University Teaching Hospital, Ikeja 100271, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3377-307X","authenticated-orcid":false,"given":"Kannan","family":"Kanthaiah","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global burden of untreated caries: A systematic review and meta regression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J. 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