{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:45:36Z","timestamp":1790117136483,"version":"4.0.1"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Alzheimer\u2019s disease is a slowly progressing neurodegenerative illness and the most common form of dementia. This pathology leads to an increase in cognitive decline and is responsible, in patients, for several difficulties in performing various activities of daily living, such as oral hygiene. Several experimental studies have shown that oral health in patients with Alzheimer\u2019s disease worsens in direct proportion to the progression of the disease due to the appearance of gingivitis and periodontitis. Methods: This clinical literature review aims to evaluate a possible correlation between periodontal disease and Alzheimer\u2019s disease, trying to understand if the periopathogens can contribute to the onset or the progression of Alzheimer\u2019s disease (AD). The study was conducted on the database PubMed (MEDLINE) of full-text systematic reviews in English on humans and animals that were published in the last five years, from 2018 to 2023. This returned 50 publications, which, once the eligibility criteria were applied, resulted in the 10 publications examined in this review. The selected articles were organized through the construction of tables, analyzed, and compared through Judith Garrard\u2019s Matrix method to arrive at the review results. Results: Infection by periopathogens can increase the risk of developing Alzheimer\u2019s disease, but also the onset of the latter can make it more difficult to maintain proper oral hygiene, favoring the onset of periodontal disease: it is possible to affirm the existence of a correlation between periodontitis and AD. It was found that patients exposed to chronic periodontitis have a greater risk of developing a cognitive decline or AD and that oral pathogens can be responsible for neuropathologies and increasing systemic inflammation. Conclusions: Periodontitis and periodontal pathogens represent a real risk factor for the onset or worsening of AD; however, the pathogenetic mechanism is still not completely clear.<\/jats:p>","DOI":"10.3390\/dj12100331","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:56:32Z","timestamp":1729155392000},"page":"331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Correlation between Periodontitis and Onset of Alzheimer\u2019s Disease: A Literature Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1419-0898","authenticated-orcid":false,"given":"Antonio","family":"Barbarisi","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5539-207X","authenticated-orcid":false,"given":"Valeria","family":"Visconti","sequence":"additional","affiliation":[{"name":"Private Practitioner, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-1812","authenticated-orcid":false,"given":"Dorina","family":"Lauritano","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cremonini","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"},{"name":"Postgraduate School of Orthodontics, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Caccianiga","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Ceraulo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, 20100 Monza, Italy"},{"name":"Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","unstructured":"Lindhe, J., and Lang, N.P. (2016). Parodontologia Clinica e Implantologia Orale, Edi Ermes. [7th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.clinthera.2018.01.011","article-title":"Type 1 Diabetes and Periodontal Health","volume":"40","year":"2018","journal-title":"Clin. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1002\/JPER.17-0719","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Chapple","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol. 2000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-030-96881-6_8","article-title":"Recent updates on microbial biofilms in periodontitis: An analysis of in vitro biofilm models","volume":"1373","author":"Prado","year":"2022","journal-title":"Periodontitis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/erm.2013.8","article-title":"Inflammatory mediators in the pathogenesis of periodontitis","volume":"15","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0022034517693567","article-title":"The Global Burden of Oral Disease: Research and Public Health Significance","volume":"96","author":"Dye","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/prd.12337","article-title":"A public health approach for prevention of periodontal disease","volume":"84","author":"Janakiram","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global burden of oral conditions in 1990\u20132010: A systematic analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0022034517693566","article-title":"Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990\u20132015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors","volume":"96","author":"Kassebaum","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Mokdad","year":"2017","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/odi.12428","article-title":"Global burden of oral diseases: Emerging concepts, management and interplay with systemic health","volume":"22","author":"Jin","year":"2016","journal-title":"Oral Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.19256\/d.cadmos.05.2021.05","article-title":"Periodontitis and Italians (2016\u20132020): Need for clinical guidelines to perform effective therapy","volume":"89","author":"Raspini","year":"2021","journal-title":"Dent. Cadmos"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","article-title":"Risk factors for periodontal disease","volume":"62","author":"Genco","year":"2013","journal-title":"Periodontol. 2000"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"ref_17","unstructured":"Giorgio, V., Marcello, C., and Pini, P.G.P. (2011). Parodontologia Clinica, Quintessenza."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/00220345211000656","article-title":"Filifactor alocis: Recent Insights and Advances","volume":"100","author":"Aja","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1996","DOI":"10.1002\/rmv.1996","article-title":"Contribution of herpesviruses in the progression of periodontal and peri-implant diseases in systemically healthy individuals","volume":"28","author":"Binshabaib","year":"2018","journal-title":"Rev. Med. Virol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1034\/j.1399-302x.2000.150501.x","article-title":"Herpesviruses: A unifying causative factor in periodontitis?","volume":"15","author":"Slots","year":"2000","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_21","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde Allgemeine Zeitschrift fur Psychiatrie und Psychisch-gerichtliche Medizin","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Clin. Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer\u2019s 1907 paper, Uber eine eigenartige Erkankung der Hirnrinde","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin Anat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.24272\/j.issn.2095-8137.2021.479","article-title":"Adult hippocampal neurogenesis and its impairment in Alzheimer\u2019s disease","volume":"43","author":"Kim","year":"2022","journal-title":"Zool. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.5005\/jp-journals-10024-2288","article-title":"Oral Health Status in Alzheimer\u2019s Disease Patients: A Descriptive Study in an Italian Population","volume":"19","author":"Costi","year":"2018","journal-title":"J. Contemp. Dent. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00784-017-2264-2","article-title":"Oral hygiene and oral health in older people with dementia: A comprehensive review with focus on oral soft tissues","volume":"22","author":"Delwel","year":"2018","journal-title":"Clin. Oral Investig."},{"key":"ref_26","first-page":"30","article-title":"The effects of oral health on systemic health","volume":"65","author":"Kane","year":"2017","journal-title":"Gen. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/jcpe.13016","article-title":"Association between periodontitis and risk of Alzheimer\u2019s disease, mild cognitive impairment and subjective cognitive decline: A case-control study","volume":"45","author":"Holmer","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1093\/brain\/awz268","article-title":"The bivariate distribution of amyloid-beta and tau: Relationship with established neurocognitive clinical syndromes","volume":"142","author":"Jack","year":"2019","journal-title":"Brain"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrneurol.2015.251","article-title":"Suspected non-Alzheimer disease pathophysiology\u2014Concept and controversy","volume":"12","author":"Jack","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Said-Sadier, N., Sayegh, B., Farah, R., Abbas, L.A., Dweik, R., Tang, N., and Ojcius, D.M. (2023). Association between Periodontal Disease and Cognitive Impairment in Adults. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064707"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/odi.14054","article-title":"Periodontal bacteria in the brain-Implication for Alzheimer\u2019s disease: A systematic review","volume":"29","author":"Sanhueza","year":"2023","journal-title":"Oral Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.jds.2022.07.001","article-title":"Association of periodontitis and oral microbiomes with Alzheimer\u2019s disease: A narrative systematic review","volume":"17","author":"Mao","year":"2022","journal-title":"J. Dent. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pisani, F., Pisani, V., Arcangeli, F., Harding, A., and Singhrao, S.K. (2022). The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer\u2019s Disease Pathology. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19159386"},{"key":"ref_35","first-page":"144","article-title":"Association of Alzheimer\u2019s disease and periodontitis\u2014A systematic review and meta-analysis of evidence from observational studies","volume":"95","author":"Kaliamoorthy","year":"2022","journal-title":"Med. Pharm. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/ADR-200237","article-title":"Porphyromonas gingivalis as a Risk Factor to Alzheimer\u2019s Disease: A Systematic Review","volume":"5","author":"Elwishahy","year":"2021","journal-title":"J. Alzheimers Dis. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Borsa, L., Dubois, M., Sacco, G., and Lupi, L. (2021). Analysis the Link between Periodontal Diseases and Alzheimer\u2019s Disease: A Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18179312"},{"key":"ref_38","first-page":"37","article-title":"The role of periodontal bacteria, Porphyromonas Gingivalis, in Alzheimer\u2019s disease pathogenesis and aggravation: A review","volume":"35","author":"Lorenzi","year":"2021","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00784-020-03764-w","article-title":"Relationship of Porphyromonas gingivalis and Alzheimer\u2019s disease: A systematic review of pre-clinical studies","volume":"25","author":"Costa","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Dioguardi, M., Crincoli, V., Laino, L., Alovisi, M., Sovereto, D., Mastrangelo, F., Russo, L.L., and Muzio, L.L. (2020). The Role of Periodontitis and Periodontal Bacteria in the Onset and Progression of Alzheimer\u2019s Disease: A Systematic Review. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020495"},{"key":"ref_41","first-page":"1148","article-title":"Periodontal Disease and Alzheimer\u2019s: Insights from a Systematic Literature Network Analysis","volume":"11","author":"Villar","year":"2024","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100062","DOI":"10.1016\/j.dentre.2022.100062","article-title":"The link between periodontitis and Alzheimer\u2019s disease\u2014Emerging clinical evidence","volume":"3","author":"Wu","year":"2023","journal-title":"Dent. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/oral4010006","article-title":"Periodontitis and Alzheimer\u2019s Disease: Is There a Connection?","volume":"4","author":"Lundergan","year":"2024","journal-title":"Oral"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/10\/331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:15:02Z","timestamp":1760112902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/12\/10\/331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["dj12100331"],"URL":"https:\/\/doi.org\/10.3390\/dj12100331","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,17]]}}}