{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:08:46Z","timestamp":1793315326583,"version":"4.5.0"},"reference-count":356,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"School of Dental Medicine (Clinic for Conservative Dentistry and Periodontology), Christian Albrechts University, Kiel, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: As a unique joint that facilitates the articulation of the upper and lower jaws, the temporomandibular joint (TMJ) is concerned with several critical functions, such as speech and mastication. Pain that can become incapacitating is a result of temporomandibular disorders (TMDs), which are complex disorders affecting the masticatory muscles and the TMJ. Several anomalies and TMDs have an interdisciplinary relationship. Complementary and concurrent disorders may be caused by occlusal anomalies, psychological disorders, and changes in spine posture. Methods: This article examines the clinical characteristics of TMDs, their classification, their etiological factors, and the impact of TMJ disorders on the human body with reference to their anatomies and histological structures. Results: The clinical picture of some TMJ pathologies may be unknown, so certain biomarkers, such as cytokines, may be useful for an accurate diagnosis as they are frequently seen in TMJ disorders. Furthermore, novel therapeutic approaches that target pro-inflammatory cytokines and treat TMDs by using tissue engineering and regenerative medicine while permitting TMJ cartilage and bone regeneration may offer numerous benefits that require clinical translation. Conclusions: Implementation of recent modalities such as microvesicles and platelet-rich plasma in growth factors may provide a promising approach to enhance bone formation. In addition, we target different biological markers that give insights into the introduction of new pharmaceutical agents for therapy.<\/jats:p>","DOI":"10.3390\/dj12110357","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:05:41Z","timestamp":1731045941000},"page":"357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-7516","authenticated-orcid":false,"given":"Marwa M. S.","family":"Abbass","sequence":"first","affiliation":[{"name":"Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"},{"name":"Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-6935","authenticated-orcid":false,"given":"Dina","family":"Rady","sequence":"additional","affiliation":[{"name":"Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"},{"name":"Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-8523","authenticated-orcid":false,"given":"Sara","family":"El Moshy","sequence":"additional","affiliation":[{"name":"Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"},{"name":"Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-5941","authenticated-orcid":false,"given":"Israa","family":"Ahmed Radwan","sequence":"additional","affiliation":[{"name":"Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"},{"name":"Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al-Hassan Soliman","family":"Wadan","sequence":"additional","affiliation":[{"name":"Oral Biology Department, Faculty of Dentistry, Galala University, Attaka 15888, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-8075","authenticated-orcid":false,"given":"Christof E.","family":"D\u00f6rfer","sequence":"additional","affiliation":[{"name":"Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 43517 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim M. Fawzy","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Stem Cells and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo 11435, Egypt"},{"name":"Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, 43517 Kiel, Germany"},{"name":"Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo 24105, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref_1","unstructured":"Okeson, J.P. (2019). Management of Temporomandibular Disorders and Occlusion-E-Book, Elsevier Health Sciences."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sambataro, S., Cervino, G., Bocchieri, S., La Bruna, R., and Cicci\u00f9, M. (2019). TMJ dysfunctions systemic implications and postural assessments: A review of recent literature. J. Funct. Morphol. 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