{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:46:43Z","timestamp":1793155603280,"version":"4.5.0"},"reference-count":117,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Electronic cigarettes (e-cigarettes) are commonly used by former smokers as an alternative product to conventional cigarettes and also by young adults and adolescents to deliver nicotine. E-cigarettes are thought to be a less harmful and more socially acceptable alternative to tobacco smoking; however, their long-term effects on health, including oral health, are currently unknown. Methods: A literature search for relevant papers indexed in the literature from 2016 to 2023 was conducted using the PubMed, Scopus, and Google Scholar databases. In our paper, we included clinical trials and both in vivo and in vitro research concerning the impact of e-cigarettes on oral health. Results: E-cigarettes impact the oral cavity, which is directly exposed to inhaled chemicals present in e-cigarette aerosols. The use of e-cigarettes has been linked to teeth discoloration and dental caries, promoting the development of periodontal diseases and causing oral mucosa lesions, including oral cancer. E-cigarette aerosols might also negatively affect the oral microbiome by suppressing the growth of commensal bacteria and increasing the population of bacteria responsible for developing numerous oral disorders. E-cigarettes also impact saliva composition and its properties, including reducing saliva\u2019s antibacterial and antioxidant properties, which may subsequently lead to the promotion of oral diseases. Conclusions: The outcomes suggest that e-cigarette usage may cause the development of oral diseases, however further longitudinal studies of a larger and homogenous group of e-cigarette users are required.<\/jats:p>","DOI":"10.3390\/dj12120404","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T08:40:10Z","timestamp":1733820010000},"page":"404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Impact of E-Cigarettes on Oral Health\u2014A Narrative Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-4460","authenticated-orcid":false,"given":"Dominika","family":"Cicho\u0144ska","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Gda\u0144sk, 80-208 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-1469","authenticated-orcid":false,"given":"Aida","family":"Kusiak","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Gda\u0144sk, 80-208 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-3068","authenticated-orcid":false,"given":"Maciej L.","family":"Goniewicz","sequence":"additional","affiliation":[{"name":"Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14203, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0972-124X.65442","article-title":"Nicotine and periodontal tissues","volume":"14","author":"Malhotra","year":"2010","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_2","unstructured":"World Health Organization (2024, January 10). Media Centre Tobacco Fact Sheet. Available online: https:\/\/www.who.int\/docs\/default-source\/campaigns-and-initiatives\/world-no-tobacco-day-2020\/wntd-tobacco-fact-sheet.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hoffmann, D., and Hecht, S.S. (1989). Advances in tobacco carcinogenesis. Handbook of Experimental Pharmacology, Springer.","DOI":"10.1007\/978-3-642-74775-5_3"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kusiak, A., Maj, A., Cicho\u0144ska, D., Kocha\u0144ska, B., Cydejko, A., and \u015awietlik, D. (2020). The Analysis of the Frequency of Leukoplakia in Reference of Tobacco Smoking among Northern Polish Population. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186919"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.envres.2018.11.012","article-title":"Risk assessment of toxicants on WHO TobReg priority list in mainstream cigarette smoke using human- smoked yields of Korean smokers","volume":"169","author":"Pack","year":"2019","journal-title":"Environ. Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yu, G., Phillips, S., Gail, M.H., Goedert, J.J., Humphrys, M.S., Ravel, J., Ren, Y., and Caporaso, N.E. (2017). The effect of cigarette smoking on the oral and nasal microbiota. Microbiome, 5.","DOI":"10.1186\/s40168-016-0226-6"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5455\/msm.2012.24.274-276","article-title":"Smoking and periodontal disease","volume":"24","author":"Borojevic","year":"2012","journal-title":"Mater. Sociomed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2221112","DOI":"10.1155\/2021\/2221112","article-title":"The Effect of Smoking on Salivary Calcium Levels, Calcium Intake, and Bleeding on Probing in Female","volume":"2021","author":"Tjahajawati","year":"2021","journal-title":"Int. J. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Al Kawas, S., Al-Marzooq, F., Rahman, B., Shearston, J.A., Saad, H., Benzina, D., and Weitzman, M. (2021). The impact of smoking different tobacco types on the subgingival microbiome and periodontal health: A pilot study. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-80937-3"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4103\/0970-9290.44540","article-title":"Tobacco smoking and surgical healing of oral tissues: A review","volume":"19","author":"Balaji","year":"2008","journal-title":"Indian J. Dent. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, D., Long, J., Quigley, J., Lee, C., McCarthy, A., and Kavanagh, P. (2021). Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: A systematic review and meta-analysis. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-10935-1"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jadohealth.2014.07.015","article-title":"Rise in Electronic Cigarette Use Among Adolescents in Poland","volume":"55","author":"Goniewicz","year":"2014","journal-title":"J. Adelesc. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.amepre.2010.12.007","article-title":"Tracking the rise in popularity of electronic nicotine delivery systems (electronic cigarettes) using search query surveillance","volume":"40","author":"Ayers","year":"2011","journal-title":"Am. J. Prev. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/j.1360-0443.2011.03505.x","article-title":"Electronic Cigarette: Users profile, utilization, satisfaction and perceived efficiancy","volume":"106","author":"Etter","year":"2011","journal-title":"Addiction"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1183\/23120541.00976-2020","article-title":"Prospective association between use of electronic cigarettes and use of conventional cigarettes: A systematic review and meta-analysis","volume":"7","author":"Adermark","year":"2021","journal-title":"ERJ Open Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Jankowski, M., Krzystanek, M., Zejda, J.E., Majek, P., Lubanski, J., Lawson, J.A., and Brozek, G. (2019). E-Cigarettes are More Addictive than Traditional Cigarettes-A Study in Highly Educated Young People. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16132279"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.31128\/AJGP-03-20-5287","article-title":"Smoking cessation","volume":"49","author":"Zwar","year":"2020","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2011.05.015","article-title":"Non-clinical safety and pharmacokinetic evaluations of propylene glycol aerosol in Sprague-Dawley rats and Beagle dogs","volume":"287","author":"Werley","year":"2011","journal-title":"Toxicology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/jamp.2008.0740","article-title":"Evaluation of lung tolerance of ethanol, propylene glycol, and sorbitan monooleate as solvents in medical aerosols","volume":"23","author":"Montharu","year":"2010","journal-title":"J. Aerosol Med. Pulm. Drug Deliv."},{"key":"ref_20","first-page":"16","article-title":"A Dental Perspective On Electronic Cigarettes: The Good, The Bad and The Ugly","volume":"6","author":"Holliday","year":"2015","journal-title":"Oral Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"h4863","DOI":"10.1136\/bmj.h4863","article-title":"Evidence about electronic cigarettes: A foundation built on rock or sand?","volume":"351","author":"McKee","year":"2015","journal-title":"BMJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1056\/NEJMc1413069","article-title":"Hidden Formaldehyde in E-Cigarette Aerosols","volume":"372","author":"Jensen","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ypmed.2014.10.009","article-title":"A systematic review of health effects of electronic cigarettes","volume":"69","author":"Pisinger","year":"2014","journal-title":"Prev. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/tobaccocontrol-2012-050859","article-title":"Levels of selected carcinogens and toxicants in vapour from electronic cigarettes","volume":"23","author":"Goniewicz","year":"2014","journal-title":"Tob. Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000353253","article-title":"Electronic cigarettes: A short review","volume":"86","author":"Bertholon","year":"2013","journal-title":"Respiration"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3109\/08958378.2012.744781","article-title":"Electronic cigarette aerosol particle size distribution measurements","volume":"24","author":"Ingebrethsen","year":"2012","journal-title":"Inhal. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"ii81","DOI":"10.1136\/tobaccocontrol-2016-053205","article-title":"Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS)","volume":"25","author":"Leigh","year":"2016","journal-title":"Tob. Control"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.reprotox.2012.08.001","article-title":"Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models","volume":"4","author":"Bahl","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"ref_29","first-page":"14","article-title":"E-cigarettes: An evidence update","volume":"11","author":"McNeill","year":"2015","journal-title":"A report commissioned by Public Health England. Public Health Engl."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/tobaccocontrol-2013-051476","article-title":"Electronic cigarettes: Product characterization and design considerations","volume":"23","author":"Brown","year":"2014","journal-title":"Tob. Control"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Chen, M.S., Hall, M.G., Parada, H., Peebles, K., Brodar, K.E., and Brewer, N.T. (2017). Symptoms during adolescents\u2019 first use of cigarettes and e-cigarettes: A pilot study. Int. J. Environ. Res. Public Health, 14.","DOI":"10.3390\/ijerph14101260"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"77196","DOI":"10.18632\/oncotarget.12857","article-title":"E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts","volume":"7","author":"Sundar","year":"2016","journal-title":"Oncotarget"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ji, E.H., Sun, B., Zhao, T., Shu, S., Chang, C.H., Messadi, D., Xia, T., Zhu, Y., and Hu, S. (2016). Characterization of Electronic Cigarette Aerosol and Its Induction of Oxidative Stress Response in Oral Keratinocytes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0169380"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/tobaccocontrol-2013-051470","article-title":"Electronic cigarettes: Human health effects","volume":"23","year":"2014","journal-title":"Tob. Control"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e108342","DOI":"10.1371\/journal.pone.0108342","article-title":"Electronic Cigarette Liquid Increases Inflammation and Virus Infection in Primary Human Airway Epithelial Cells","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/jre.12458","article-title":"Increasing popularity of waterpipe tobacco smoking and electronic cigarette use: Implications for oral healthcare","volume":"52","author":"Eissenberg","year":"2017","journal-title":"J. Periodontal. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bj.2020.07.003","article-title":"Effects of electronic cigarette aerosol exposure on oral and systemic health","volume":"44","author":"Montierth","year":"2021","journal-title":"Biomed. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408444.2020.1713726","article-title":"The oral health impact of electronic cigarette use: A systematic review","volume":"50","author":"Yang","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jerd.12583","article-title":"Potential oral health effects of e-cigarettes and vaping: A review and case reports","volume":"32","author":"Irusa","year":"2020","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/00220345211002116","article-title":"Electronic Cigarettes and Oral Health","volume":"100","author":"Holliday","year":"2021","journal-title":"J. Dent. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bjoms.2023.03.013","article-title":"e-Cigarettes and Oral Cancer: What do we know so far?","volume":"61","author":"Cameron","year":"2023","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e0324","DOI":"10.1097\/MD.0000000000010324","article-title":"Efficiency and adverse events of electronic cigarettes: A systematic review and meta-analysis (PRISMA-compliant article)","volume":"97","author":"Liu","year":"2018","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.drugalcdep.2018.11.030","article-title":"Adverse symptoms users attribute to e-cigarettes: Results from a national survey of US adults","volume":"196","author":"King","year":"2019","journal-title":"Drug Alcohol Depend."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Polosa, R., Caponnetto, P., Morjaria, J.B., Papale, G., Campagna, D., and Russo, C. (2011). Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: A prospective 6-month pilot study. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-786"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/ntr\/ntz130","article-title":"The Impact of E-liquid Propylene Glycol and Vegetable Glycerin Ratio on Ratings of Subjective Effects, Reinforcement Value, and Use in Current Smokers","volume":"22","author":"Smith","year":"2020","journal-title":"Nicotine Tob. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41415-021-3563-1","article-title":"Erosive potential of commonly available vapes: A cause for concern?","volume":"231","author":"Fairchild","year":"2021","journal-title":"Br. Dent. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/odi.13564","article-title":"Electronic cigarette vapor increases Streptococcus mutans growth, adhesion, biofilm formation, and expression of the biofilm-associated genes","volume":"27","author":"Rouabhia","year":"2021","journal-title":"Oral Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.5958\/0976-5506.2019.01503.1","article-title":"Effect of electronic cigarette usage on oral health: A 6-month prospective study","volume":"10","author":"Ismail","year":"2019","journal-title":"Ind. J. Publ. Health Res. Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1093\/pubmed\/fdy082","article-title":"Association of e-cigarette use with oral health: A population-based cross-sectional questionnaire study","volume":"41","author":"Huilgol","year":"2019","journal-title":"J. Public Health"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kim, S.A., Smith, S., Beauchamp, C., Song, Y., Chiang, M., Giuseppetti, A., Frukhtbeyn, S., Shaffer, I., Wilhide, J., and Routkevitch, D. (2018). Cariogenic potential of sweet flavors in electronic-cigarette liquids. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203717"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/jerd.12436","article-title":"The effect of electronic cigarettes on dental enamel color","volume":"31","author":"Tirapelli","year":"2019","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"993","DOI":"10.12669\/pjms.36.5.2303","article-title":"Influence of electronic nicotine delivery systems (ENDS) in comparison to conventional cigarette on color stability of dental restorative materials","volume":"36","author":"Vohra","year":"2020","journal-title":"Pak. J. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.3390\/ijerph110404356","article-title":"Characteristics, perceived side effects and benefits of electronic cigar- ette use: A worldwide survey of more than 19,000 consumers","volume":"11","author":"Farsalinos","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.etap.2018.05.016","article-title":"Clinical and radiographic periodontal status and whole salivary cotinine, IL-1b and IL-6 levels in cigarette- and water-pipe-smokers and e-cig users","volume":"61","author":"Mokeem","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/JPER.19-0060","article-title":"Associations of electronic and conventional cigarette use with periodontal disease in South Korean adults","volume":"91","author":"Jeong","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1007\/s00784-023-05162-4","article-title":"The impact of electronic and conventional cigarettes on periodontal health-a systematic review and meta-analysis","volume":"27","author":"Thiem","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.archoralbio.2019.05.001","article-title":"Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers","volume":"102","author":"BinShabaib","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.adaj.2018.12.004","article-title":"Tobacco-use patterns and self-reported oral health outcomes: A cross-sectional assssment of the Population Assessment of Tobacco and Health study, 2013\u20132014","volume":"150","author":"Vora","year":"2019","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ibraheem, W.I., Fageeh, H.I., Preethanath, R.S., Alzahrani, F.A., Al-Zawawi, A.S., Divakar, D.D., and Al-Kheraif, A.A. (2020). Comparison of RANKL and osteoprotegerin levels in the gingival crevicular fluid of young cigarette- and waterpipe-smokers and individuals using electronic nicotine delivery systems. Arch. Oral Biol., 115.","DOI":"10.1016\/j.archoralbio.2020.104714"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Xu, F., Aboseria, E., Janal, M.N., Pushalkar, S., Bederoff, M.V., Vasconcelos, R., Sapru, S., Paul, B., Queiroz, E., and Makwana, S. (2021). Comparative Effects of E-Cigarette Aerosol on Periodontium of Periodontitis Patients. Front. Oral Health, 2.","DOI":"10.3389\/froh.2021.729144"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/odi.12902","article-title":"Oral Candida carriage among cigarette- and waterpipe-smokers, and electronic-cigarette users","volume":"25","author":"Mokeem","year":"2019","journal-title":"Oral Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/00016357.2017.1406613","article-title":"Oral mucosal lesions in electronic cigarettes consumers versus former smokers","volume":"76","author":"Bardellini","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/154411130301400403","article-title":"Chronic hyperplastic candido- sis\/candidiasis (candida leukoplakia)","volume":"14","author":"Sitheeque","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.bjoms.2015.06.003","article-title":"Lichenoid eruption associated with use of an e-cigarette","volume":"54","author":"Bartram","year":"2016","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"393","DOI":"10.20344\/amp.5528","article-title":"Lingua villosa nigra associated with the use of electronic cigarette","volume":"28","author":"Farinha","year":"2015","journal-title":"Acta Med. Port."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Li, Q., Zhan, Y., Wang, L., Leischow, S.J., and Zeng, D.D. (2016). Analysis of symptoms and their potential associations with e-liquids ' components: A social media study. BMC Public Health, 16.","DOI":"10.1186\/s12889-016-3326-0"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/16066359.2015.1077947","article-title":"Views of experienced electronic cigarette users","volume":"24","author":"Baweja","year":"2016","journal-title":"Addict. Res. Theory"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4172\/2161-119X.1000304","article-title":"Oral carcinoma associated with chronic use of electronic cigarettes","volume":"7","author":"Nguyen","year":"2017","journal-title":"Otolaryngology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12223-014-0342-2","article-title":"The oral microbiome diversity and its relation to human diseases","volume":"60","author":"He","year":"2015","journal-title":"Folia Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2334\/josnusd.16-0856","article-title":"The oral microbiome and human health","volume":"59","author":"Yamashita","year":"2017","journal-title":"J. Oral Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1128\/IAI.05371-11","article-title":"Tobacco smoking affects bacterial acquisition and colonization in oral biofilms","volume":"79","author":"Kumar","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"ii11","DOI":"10.1136\/tobaccocontrol-2013-051482","article-title":"Chemical evaluation of electronic cigarettes","volume":"23","author":"Cheng","year":"2014","journal-title":"Tob. Control"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"100884","DOI":"10.1016\/j.isci.2020.100884","article-title":"Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection","volume":"23","author":"Pushalkar","year":"2020","journal-title":"iScience"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1034\/j.1600-051X.2003.00376.x","article-title":"Distribution of selected bacterial species on intraoral surfaces","volume":"30","author":"Mager","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5430\/jer.v2n2p92","article-title":"Oral microbiome and history of smoking and colorectal cancer","volume":"2","author":"Kato","year":"2016","journal-title":"J. Epidemiol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Takeuchi, H., Hirano, T., Whitmore, S.E., Morisaki, I., Amano, A., and Lamont, R.J. (2013). The Serine Phosphatase SerB of Porphyromonas gingivalis Suppresses IL-8 Production by Dephosphorylation of NF-\u03baB RelA\/p65. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003326"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Catala-Valentin, A., Bernard, J.N., Caldwell, M., Maxson, J., Moore, S.D., and Andl, C.D. (2022). E-Cigarette Aerosol Exposure Favors the Growth and Colonization of Oral Streptococcus mutans Compared to Commensal Streptococci. Microbiol. Spectr., 10.","DOI":"10.1128\/spectrum.02421-21"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/dna.2009.0868","article-title":"Bacterial and host interactions of oral streptococci","volume":"28","author":"Kreth","year":"2009","journal-title":"DNA Cell Biol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Nelson, J.M., Cuadra, G.A., and Palazzolo, D.L. (2019). A comparison of flavorless electronic cigarette-generated aerosol and conventional cigarette smoke on the planktonic growth of common oral commensal streptococci. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16245004"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Cuadra, G.A., Smith, M.T., Nelson, J.M., Loh, E.K., and Palazzolo, D.L. (2019). A comparison of flavorless electronic cigarette-generated aerosol and conventional cigarette smoke on the survival and growth of common oral commensal streptococci. Int. J. Environ. Res. Public Health, 16.","DOI":"10.1101\/529909"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Chopyk, J., Bojanowski, C.M., Shin, J., Moshensky, A., Fuentes, A.L., Bonde, S.S., Chuki, D., Pride, D.T., and Crotty Alexander, L.E. (2021). Compositional Differences in the Oral Microbiome of E-cigarette Users. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.599664"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40248-018-0123-x","article-title":"Non-typeable Haemophilus influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease","volume":"13","author":"Sriram","year":"2018","journal-title":"Multidiscip. Respir. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s12931-019-1206-8","article-title":"Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens","volume":"20","author":"Gilpin","year":"2019","journal-title":"Respir. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"eaaz0108","DOI":"10.1126\/sciadv.aaz0108","article-title":"Adverse effects of electronic cigarettes on the disease-naive oral microbiome","volume":"6","author":"Ganesan","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0975-7406.137251","article-title":"Immunology of oral candidiasis","volume":"6","author":"Dineshshankar","year":"2014","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Haghighi, F., Andriasian, L., Tran, N.C., and Lux, R. (2022). Effect of Cigarette and E-Cigarette Smoke Condensates on Candida albicans Biofilm Formation and Gene Expression. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19084626"},{"key":"ref_87","first-page":"1092","article-title":"A pilot investigation into the influence of electronic cigarettes on oral bacteria","volume":"38","author":"Kusiak","year":"2021","journal-title":"Adv. Dermatol. Alergol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13756-020-0705-1","article-title":"Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: Prevalence, risk factors, and molecular epidemiology","volume":"9","author":"Le","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e4693","DOI":"10.7717\/peerj.4693","article-title":"Effects of tobacco smoke and electronic cigarette vapor exposure on the oral and gut microbiota in humans: A pilot study","volume":"6","author":"Stewart","year":"2018","journal-title":"PeerJ"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/omi.12361","article-title":"Electronic cigarette use enriches periodontal pathogens","volume":"37","author":"Xu","year":"2022","journal-title":"Mol. Oral Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s42770-022-00721-5","article-title":"Effect of electronic cigarette and tobacco smoking on the human saliva microbial community","volume":"53","author":"Wang","year":"2022","journal-title":"Braz. J. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/ismej.2016.37","article-title":"Cigarette smoking and the oral microbiome in a large study of American adults","volume":"10","author":"Wu","year":"2016","journal-title":"ISME J."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Park, B., Koh, H., Patatanian, M., Reyes-Caballero, H., Zhao, N., Meinert, J., Holbrook, J.T., Leinbach, L.I., and Biswal, S. (2023). The mediating roles of the oral microbiome in saliva and subgingival sites between e-cigarette smoking and gingival inflammation. BMC Microbiol., 23.","DOI":"10.1186\/s12866-023-02779-z"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"103","DOI":"10.5507\/bp.2009.017","article-title":"Saliva as a diagnostic medium","volume":"153","author":"Pink","year":"2009","journal-title":"Biomed. Pap. Med. Fac. Palacky Univ. Olomouc."},{"key":"ref_95","first-page":"727","article-title":"Inhibition of salivary amylase activity by cigarette smoke aldehydes","volume":"59","author":"Weiner","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/BF02910990","article-title":"The role of two enzymes (LDH and PHI) and a tumour marker (CEA) in the prognostic evalution of head and neck malignancy","volume":"53","author":"Narang","year":"2001","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_97","first-page":"31","article-title":"Estimation of serum and salivary lactate dehydrogenase levels among healthy individuals and oral cancer patients- A clinical and biochemical study","volume":"2","author":"Rao","year":"2017","journal-title":"Int. J. Dent. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.31557\/APJCP.2021.22.10.3227","article-title":"Lactate Dehydrogenase Levels in the Saliva of Cigarette and E-Cigarette Smokers (Vapers): A Comparative Analysis","volume":"22","author":"Pandarathodiyil","year":"2021","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Cicho\u0144ska, D., Kr\u00f3l, O., S\u0142omi\u0144ska, E.M., Kocha\u0144ska, B., \u015awietlik, D., Ochoci\u0144ska, J., and Kusiak, A. (2021). Influence of Electronic Cigarettes on Antioxidant Capacity and Nucleotide Metabolites in Saliva. Toxics, 9.","DOI":"10.3390\/toxics9100263"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way","volume":"84","author":"Sczepanik","year":"2000","journal-title":"Periodontology"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Cicho\u0144ska, D., Kusiak, A., Kocha\u0144ska, B., Ochoci\u0144ska, J., and \u015awietlik, D. (2019). Influence of Electronic Cigarettes on Selected Antibacterial Properties of Saliva. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16224433"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/gut.31.4.378","article-title":"Mucosal immunodeficiency in smokers, and in patients with epithelial head and neck tumours","volume":"31","author":"Barton","year":"1990","journal-title":"Gut"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0003-9969(96)00104-5","article-title":"A population-based study of salivary lysozyme concentrations and candidal counts","volume":"42","author":"Yeh","year":"2018","journal-title":"Arch. Oral Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1902\/jop.2006.050186","article-title":"Immunolocalization of lactoferrin in healthy and inflamed gingival tissues","volume":"77","author":"Eberhard","year":"2006","journal-title":"J. Periodontol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/JPER.19-0457","article-title":"Inflammatory biomarkers and growth factors in saliva and gingival crevicular fluid of e-cigarette users, cigarette smokers, and dual smokers: A pilot study","volume":"91","author":"Ye","year":"2020","journal-title":"J. Periodontol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"00182","DOI":"10.1183\/23120541.00182-2019","article-title":"Systemic biomarkers in electronic cigarette users: Implications for noninvasive assessment of vaping-associated pulmonary injuries","volume":"5","author":"Singh","year":"2019","journal-title":"ERJ Open Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1038\/sj.onc.1204685","article-title":"Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis","volume":"20","author":"Alevizos","year":"2001","journal-title":"Oncogene"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"S1642","DOI":"10.4103\/jpbs.jpbs_393_21","article-title":"Comparative Evaluation of Salivary Biomarker Levels in e-Cigarette Smokers and Conventional Smokers","volume":"13","author":"Verma","year":"2021","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/1535370220941258","article-title":"Electronic nicotine delivery system-induced alterations in oral health via saliva assessment","volume":"245","author":"Alqahtani","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/odi.13533","article-title":"Salivary biomarker profiles in E-cigarette users and conventional smokers: A cross-sectional study","volume":"27","author":"Faridoun","year":"2021","journal-title":"Oral Dis."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ali, D., Kuyunov, I., Baskaradoss, J.K., and Mikami, T. (2022). Comparison of periodontal status and salivary IL-15 and -18 levels in cigarette-smokers and individuals using electronic nicotine delivery systems. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02700-6"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4103\/0972-124X.118317","article-title":"Salivary pH: A diagnostic biomarker","volume":"17","author":"Baliga","year":"2013","journal-title":"J. Indian Soc. Periodontol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/ijdr.IJDR_387_19","article-title":"Assessment of salivary thiocyanate levels and pH in the saliva of smokers and nonsmokers with chronic periodontitis\u2014A comparative study","volume":"32","author":"Kumar","year":"2021","journal-title":"Indian J. Dent. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5152\/balkanmedj.2021.20125","article-title":"Effects of Oral pH Changes on Smoking Desire","volume":"38","author":"Simsek","year":"2021","journal-title":"Balk. Med. J."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Cicho\u0144ska, D., Kusiak, A., Kocha\u0144ska, B., Ochoci\u0144ska, J., and \u015awietlik, D. (2022). Influence of Electronic Cigarettes on Selected Physicochemical Properties of Saliva. Int. J. Environ. Res. Public Health., 19.","DOI":"10.3390\/ijerph19063314"},{"key":"ref_116","first-page":"96","article-title":"Periodontal Microbiology","volume":"6","author":"Haake","year":"2002","journal-title":"Carranza\u2019s Clin. Periodontol."},{"key":"ref_117","first-page":"84","article-title":"Assessment of Salivary Composition in Smokers and Non Smokers with Chronic Periodontitis","volume":"15","author":"Shashikanth","year":"2016","journal-title":"J. Dent. Med. 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