{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:57:37Z","timestamp":1790801857836,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: We compared the camouflage effect of three white spot lesion (WSL) treatments (infiltration, nano-hydroxyapatite (nHAP) remineralization, and microabrasion) and color stability of the treated surfaces. Methods: Fifty sound extracted teeth were used in the study. WSLs were created on 40 buccal dento-enamel specimens through the use of acidic methylcellulose gel. These specimens were randomly assigned to treatment groups (n = 10 per group): negative controls, nano-hydroxyapatite (nHAP), resin infiltration, and microabrasion. After the treatment, all 50 specimens were immersed in coffee for 7 days. Color measurements were performed four times: at baseline (T0), after the demineralization procedure (T1), after the treatments (T2), and after immersion in coffee (T3). Results: No restoration of the initial enamel color was observed in any of the groups. The ICON and MA groups exhibited the highest masking effect, with the mean \u0394ET0-T2 = 7.46, although the differences among the study groups were insignificant. All three treatments increased the resistance of WSLs to discoloration in coffee compared to the negative control group; however, infiltration (\u2206ET2-T3 = 4.13) and microabrasion (\u2206ET2-T3 = 3.49) showed a better color stability tendency than nHAP remineralization (\u2206ET2-T3 = 7.26). Conclusions: Despite its well-known remineralizing and desensitizing effects, nHAP showed the least masking effect for WSLs and lower color stability compared to resin infiltration and microabrasion. However, none of the methods allowed for complete restoration of the original color. After the discoloration procedure, the color changes in the white spots treated with microabrasion and infiltration were comparable to those of the sound enamel.<\/jats:p>","DOI":"10.3390\/dj13030112","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T09:04:49Z","timestamp":1740992689000},"page":"112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Color Change and Color Stability of White Spot Lesions Treated with Resin Infiltration, Microabrasion, or Nano-Hydroxyapatite Remineralization: An In Vitro Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-7693","authenticated-orcid":false,"given":"Nina","family":"Novozhilova","sequence":"first","affiliation":[{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2021-4673","authenticated-orcid":false,"given":"Anastasia","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4494-2644","authenticated-orcid":false,"given":"Maria","family":"Polyakova","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mikheikina","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3774-3070","authenticated-orcid":false,"given":"Alexandr","family":"Zaytsev","sequence":"additional","affiliation":[{"name":"Institute of Linguistics and Intercultural Communication, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-0858","authenticated-orcid":false,"given":"Ksenia","family":"Babina","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"ref_1","first-page":"61","article-title":"Plaque Microbiome in Caries-Active and Caries-Free Teeth by Dentition","volume":"9","author":"Bhaumik","year":"2024","journal-title":"JDR Clin. Trans. Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Malin, A.J., Wang, Z., Khan, D., and McKune, S.L. (2024). The Potential Systemic Role of Diet in Dental Caries Development and Arrest: A Narrative Review. Nutrients, 16.","DOI":"10.3390\/nu16101463"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1055\/s-0043-1777051","article-title":"Caries Etiology and Preventive Measures","volume":"18","author":"Meyer","year":"2024","journal-title":"Eur. J. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e10714","DOI":"10.1016\/j.heliyon.2022.e10714","article-title":"Changes in the Global Burden of Untreated Dental Caries from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study","volume":"8","author":"Qin","year":"2022","journal-title":"Heliyon"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Campus, G., Niu, J.Y., Sezer, B., and Yu, O.Y. (2024). Prevention and Management of Dental Erosion and Decay. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04257-y"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s13312-024-3190-4","article-title":"Dental Caries in Children: An Update","volume":"61","author":"Kumar","year":"2024","journal-title":"Indian Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Xie, Z., Yu, L., Li, S., Li, J., and Liu, Y. (2023). Comparison of Therapies of White Spot Lesions: A Systematic Review and Network Meta-Analysis. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03076-x"},{"key":"ref_8","unstructured":"Daruich, P.M., and Brizuela, M. (2023). Remineralization of Initial Carious Lesions, StatPearls."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2174\/1874210601105010158","article-title":"A Review on Prevention and Treatment of Post-Orthodontic White Spot Lesions\u2014Evidence-Based Methods and Emerging Technologies","volume":"5","author":"Bergstrand","year":"2011","journal-title":"Open Dent. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-0041-1731931","article-title":"Systematic Review on White Spot Lesions Treatments","volume":"16","author":"Puleio","year":"2022","journal-title":"Eur. J. Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/ccd.ccd_216_17","article-title":"Prevention and Treatment of White Spot Lesions in Orthodontic Patients","volume":"8","author":"Khoroushi","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1007\/s00784-021-03931-7","article-title":"Efficacy of Resin Infiltration to Mask Post-Orthodontic or Non-Post-Orthodontic White Spot Lesions or Fluorosis\u2014A Systematic Review and Meta-Analysis","volume":"25","author":"Bourouni","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/JISPPD.JISPPD_242_16","article-title":"A Comparative Evaluation of the Remineralization Potential of Three Commercially Available Remineralizing Agents on White Spot Lesions in Primary Teeth: An in Vitro Study","volume":"35","author":"Kamath","year":"2017","journal-title":"J. Indian Soc. Pedod. Prev. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1590\/2177-6709.25.1.27.e1-7.onl","article-title":"Evaluation of Color Changes of White Spot Lesions Treated with Three Different Treatment Approaches: An in-Vitro Study","volume":"25","author":"Hammad","year":"2020","journal-title":"Dental Press. J. Orthod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e18283","DOI":"10.1016\/j.heliyon.2023.e18283","article-title":"Surface Roughness and Microhardness of Enamel White Spot Lesions Treated with Different Treatment Methods","volume":"9","author":"Chabuk","year":"2023","journal-title":"Heliyon"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Malcangi, G., Patano, A., Morolla, R., De Santis, M., Piras, F., Settanni, V., Mancini, A., Di Venere, D., Inchingolo, F., and Inchingolo, A.D. (2023). Analysis of Dental Enamel Remineralization: A Systematic Review of Technique Comparisons. Bioengineering, 10.","DOI":"10.3390\/bioengineering10040472"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Grohe, B., and Mittler, S. (2021). Advanced Non-Fluoride Approaches to Dental Enamel Remineralization: The next Level in Enamel Repair Management. Biomater. Biosyst., 4.","DOI":"10.1016\/j.bbiosy.2021.100029"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Carey, C.M. (2023). Remineralization of Early Enamel Lesions with Apatite-Forming Salt. Dent. J., 11.","DOI":"10.3390\/dj11080182"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Butera, A., Gallo, S., Pascadopoli, M., Montasser, M.A., Abd El Latief, M.H., Modica, G.G., and Scribante, A. (2022). Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19148676"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Anil, A., Ibraheem, W.I., Meshni, A.A., Preethanath, R.S., and Anil, S. (2022). Nano-Hydroxyapatite (NHAp) in the Remineralization of Early Dental Caries: A Scoping Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19095629"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2319\/041218-274.1","article-title":"Esthetic Improvements of Postorthodontic White-Spot Lesions Treated with Resin Infiltration and Microabrasion: A Split-Mouth, Randomized Clinical Trial","volume":"89","author":"Gu","year":"2019","journal-title":"Angle Orthod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2174\/1874210601812010406","article-title":"Overview of Calcium Phosphates Used in Biomimetic Oral Care","volume":"12","author":"Meyer","year":"2018","journal-title":"Open Dent. J."},{"key":"ref_23","first-page":"7","article-title":"Synthetic Hydroxyapatite as a Biomimetic Oral Care Agent","volume":"16","author":"Enax","year":"2018","journal-title":"Oral Health Prev. Dent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.identj.2024.01.028","article-title":"Effects of Hydroxyapatite-Containing Toothpastes on Some Caries-Related Variables: A Randomised Clinical Trial","volume":"74","author":"Campus","year":"2024","journal-title":"Int. Dent. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4103\/jispcd.JISPCD_493_19","article-title":"Qualitative and Quantitative Assessment of Remineralizing Effect of Prophylactic Toothpaste Promoting Brushite Formation: A Randomized Clinical Trial","volume":"10","author":"Polyakova","year":"2020","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/jispcd.JISPCD_333_21","article-title":"The Effect of Toothpastes Containing Hydroxyapatite, Fluoroapatite, and Zn-Mg-Hydroxyapatite Nanocrystals on Dentin Hypersensitivity: A Randomized Clinical Trial","volume":"12","author":"Polyakova","year":"2022","journal-title":"J. Int. Soc. Prev. Community Dent."},{"key":"ref_27","first-page":"148","article-title":"Biomimetic Hydroxyapatite and Caries Prevention: A Systematic Review and Meta-Analysis","volume":"55","author":"Limeback","year":"2021","journal-title":"Can. J. Dent. Hyg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4103\/1735-3327.294328","article-title":"Comparison of the Effects of Toothpastes Containing Nanohydroxyapatite and Fluoride on White Spot Lesions in Orthodontic Patients: A Randomized Clinical Trial","volume":"17","author":"Badiee","year":"2020","journal-title":"Dent. Res. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7256056","DOI":"10.1155\/2021\/7256056","article-title":"Nano-Hydroxyapatite Gel and Its Effects on Remineralization of Artificial Carious Lesions","volume":"2021","author":"Juntavee","year":"2021","journal-title":"Int. J. Dent."},{"key":"ref_30","first-page":"1605","article-title":"Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial","volume":"24","author":"Cocco","year":"2025","journal-title":"Int. Dent. J."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Butera, A., Maiorani, C., Gallo, S., Pascadopoli, M., Quintini, M., Lelli, M., Tarterini, F., Foltran, I., and Scribante, A. (2023). Biomimetic Action of Zinc Hydroxyapatite on Remineralization of Enamel and Dentin: A Review. Biomimetics, 8.","DOI":"10.3390\/biomimetics8010071"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100865","DOI":"10.1016\/j.ortho.2024.100865","article-title":"Fluoride-Amorphous Calcium Phosphate and Biomimetic Nano-Hydroxyapatite for Enamel Remineralization: An in-Vitro Study of Surface Microhardness and Composition","volume":"22","author":"Hamed","year":"2024","journal-title":"Int. Orthod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"20503121231221634","DOI":"10.1177\/20503121231221634","article-title":"Remineralization Potential of Strontium-Doped Nano-Hydroxyapatite Dentifrice and Casein Phosphopeptide-Amorphous Calcium Phosphate Cream on White Spot Lesions in Enamel Following Orthodontic Debonding\u2014A Randomized Controlled Trial","volume":"12","author":"Rajendran","year":"2024","journal-title":"SAGE Open Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/jerd.12969","article-title":"Nano-hydroxyapatite-induced Remineralization of Artificial White Spot Lesions after Bleaching Treatment with 10% Carbamide Peroxide","volume":"34","author":"Ortiz","year":"2022","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_35","first-page":"456","article-title":"Microabrasion plus Resin Infiltration in Masking White Spot Lesions","volume":"26","author":"Alrebdi","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.sjbs.2021.09.063","article-title":"Colour Stability of Resin Infiltrated White Spot Lesion after Exposure to Stain-Causing Drinks","volume":"29","author":"Alqahtani","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Saccucci, M., Corridore, D., Di Carlo, G., Bonucci, E., Cicci\u00f9, M., and Vozza, I. (2022). Assessment of Enamel Color Stability of Resins Infiltration Treatment in Human Teeth: A Systematic Review. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191811269"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40510-019-0276-y","article-title":"Comparative Evaluation of Icon\u00ae Resin Infiltration and ClinproTM XT Varnish on Colour and Fluorescence Changes of White Spot Lesions: A Randomized Controlled Trial","volume":"20","author":"Kannan","year":"2019","journal-title":"Prog. Orthod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e2834","DOI":"10.1002\/cre2.834","article-title":"Evaluating Color Stability and Enamel Surface Roughness Following Resin Infiltration Treatment","volume":"10","author":"Sabti","year":"2024","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4103\/JCDE.JCDE_95_23","article-title":"Efficacy of Microabrasion and Resin Infiltration Techniques for Masking of Fluorotic White Spot Lesions: A Randomized Clinical Study","volume":"26","author":"Asthana","year":"2023","journal-title":"J. Conserv. Dent. Endod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/CCIDE.S334633","article-title":"Effect of Ageing Process and Brushing on Color Stability and Surface Roughness of Treated White Spot Lesions: An in Vitro Analysis","volume":"13","author":"Almulhim","year":"2021","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2341\/15-319-L","article-title":"Surface Properties and Color Stability of Resin-Infiltrated Enamel Lesions","volume":"41","author":"Zhao","year":"2016","journal-title":"Oper. Dent."},{"key":"ref_43","first-page":"211","article-title":"Evaluation of Incipient Enamel-Carious\u2013like Lesion Treated with Hydroxyapatite-Chitosan Nanocomposite Hydrogel","volume":"13","author":"Fathy","year":"2024","journal-title":"J. World Fed. Orthod."},{"key":"ref_44","unstructured":"(2025, January 20). METHODS OF USE. Available online: https:\/\/sangi-eu.com\/en\/professional-use\/methods-of-use\/."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Babina, K., Polyakova, M., Sokhova, I., Doroshina, V., Zaytsev, A., Nikonova, E.E., Budylin, G.S., Shirshin, E.A., Tantardini, C., and Novozhilova, N. (2022). Translucency and Color Stability of a Simplified Shade Nanohybrid Composite after Ultrasonic Scaling and Air-Powder Polishing. Nanomaterials, 12.","DOI":"10.3390\/nano12244465"},{"key":"ref_46","first-page":"406","article-title":"Comparative Assessment of Various Composite Materials and Natural Tooth Tissue Translucencies","volume":"14","author":"Babina","year":"2019","journal-title":"Int. J. Esthet. Dent."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ejo\/cjt095","article-title":"Colour Improvement and Stability of White Spot Lesions Following Infiltration, Micro-Abrasion, or Fluoride Treatments in Vitro","volume":"36","author":"Yetkiner","year":"2014","journal-title":"Eur. J. Orthod."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Lopes, P.C., Carvalho, T., Gomes, A.T.P.C., Veiga, N., Blanco, L., Correia, M.J., and Mello-Moura, A.C.V. (2024). White Spot Lesions: Diagnosis and Treatment\u2014A Systematic Review. BMC Oral Health, 24.","DOI":"10.1186\/s12903-023-03720-6"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Dziaruddin, N., and Zakaria, A.S.I. (2022). Resin Infiltration of Non-Cavitated Enamel Lesions in Paediatric Dentistry: A Narrative Review. Children, 9.","DOI":"10.3390\/children9121893"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jdent.2018.02.004","article-title":"Remineralisation of Enamel White Spot Lesions Pre-Treated with Chitosan in the Presence of Salivary Pellicle","volume":"72","author":"Zhang","year":"2018","journal-title":"J. Dent."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e923279-1","DOI":"10.12659\/MSMBR.923279","article-title":"Discoloration of Resin Composites Induced by Coffee and Tomato Sauce and Subjected to Surface Polishing: An In Vitro Study","volume":"26","author":"Assaf","year":"2020","journal-title":"Med. Sci. Monit. Basic. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1177\/00220345890680120801","article-title":"Visual and Instrumental Colorimetric Assessments of Small Color Differences on Translucent Dental Porcelain","volume":"68","author":"Seghi","year":"1989","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Limvisitsakul, A., Komalsingsakul, A., Thamsrithip, P., Thammasupapong, Y., Chaisomsukrudee, S., Aramlerttrakul, S., and Senawongse, P. (2024). The Color Stability of Artificial White Spot Lesions Treated with Resin Infiltration after Exposure to Staining Beverages. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04693-w"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2334\/josnusd.21-0447","article-title":"Effects of Dyes Used in Photodynamic Therapy on Color Stability of Composite Resins","volume":"64","author":"Ozkocak","year":"2022","journal-title":"J. Oral. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"374","DOI":"10.2319\/050914-334.1","article-title":"Camouflage Effects Following Resin Infiltration of Postorthodontic White-Spot Lesions in Vivo: One-Year Follow-Up","volume":"85","author":"Eckstein","year":"2015","journal-title":"Angle Orthod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"103943","DOI":"10.1016\/j.jdent.2021.103943","article-title":"In-Vivo Colour Stability of Enamel after ICON\u00ae Treatment at 6 Years of Follow-up: A Prospective Single Center Study","volume":"122","author":"Mazur","year":"2022","journal-title":"J. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2341\/19-206-S","article-title":"Esthetic Management of Incisors with Diffuse and Demarcated Opacities: 24 Month Follow-up Case Report","volume":"45","author":"Jorge","year":"2020","journal-title":"Oper. Dent."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zotti, F., Albertini, L., Tomizioli, N., Capocasale, G., and Albanese, M. (2020). Resin Infiltration in Dental Fluorosis Treatment\u20141-Year Follow-Up. Medicina, 57.","DOI":"10.3390\/medicina57010022"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ajodo.2020.04.039","article-title":"A Comparison of Resin Infiltration and Microabrasion for Postorthodontic White Spot Lesion","volume":"160","author":"Shan","year":"2021","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jdent.2004.10.018","article-title":"Influence of Food-Simulating Solutions and Surface Finish on Susceptibility to Staining of Aesthetic Restorative Materials","volume":"33","author":"Bagheri","year":"2005","journal-title":"J. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1007\/s00784-020-03732-4","article-title":"Do Bleaching Gels Affect the Stability of the Masking and Caries-Arresting Effects of Caries Infiltration\u2014In Vitro","volume":"25","author":"Jansen","year":"2021","journal-title":"Clin. Oral. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1016\/j.jdent.2013.04.003","article-title":"Masking of White Spot Lesions by Resin Infiltration in Vitro","volume":"41","author":"Paris","year":"2013","journal-title":"J. Dent."},{"key":"ref_63","first-page":"394","article-title":"Color Restoration and Stability in Two Treatments for White Spot Lesions","volume":"13","author":"Silva","year":"2018","journal-title":"Int. J. Esthet. Dent."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Baptista-S\u00e1nchez, H., Antonio-Zancajo, L., Albaladejo-Mart\u00ednez, A., Colino Gallardo, P., Garcovich, D., Alvarado-Lorenzo, M., and Alvarado-Lorenzo, A. (2022). Changes in the Color and Brightness of White Spots Associated with Orthodontic Treatment 6 Months after the Application of Infiltrative Resins: Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19159277"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/3\/112\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:46:20Z","timestamp":1760028380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/3\/112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":64,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["dj13030112"],"URL":"https:\/\/doi.org\/10.3390\/dj13030112","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}