{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:49:55Z","timestamp":1778190595546,"version":"3.51.4"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helsinki and Uusimaa Hospital District (HUS), Finland","award":["TYH 2020337"],"award-info":[{"award-number":["TYH 2020337"]}]},{"name":"Helsinki and Uusimaa Hospital District (HUS), Finland","award":["TYH 2022225"],"award-info":[{"award-number":["TYH 2022225"]}]},{"name":"Helsinki and Uusimaa Hospital District (HUS), Finland","award":["Y2519SU010"],"award-info":[{"award-number":["Y2519SU010"]}]},{"name":"Helsinki and Uusimaa Hospital District (HUS), Finland","award":["202231103652"],"award-info":[{"award-number":["202231103652"]}]},{"name":"Finnish Dental Association Apollonia, Finland","award":["TYH 2020337"],"award-info":[{"award-number":["TYH 2020337"]}]},{"name":"Finnish Dental Association Apollonia, Finland","award":["TYH 2022225"],"award-info":[{"award-number":["TYH 2022225"]}]},{"name":"Finnish Dental Association Apollonia, Finland","award":["Y2519SU010"],"award-info":[{"award-number":["Y2519SU010"]}]},{"name":"Finnish Dental Association Apollonia, Finland","award":["202231103652"],"award-info":[{"award-number":["202231103652"]}]},{"name":"Karolinska Institutet, Sweden","award":["TYH 2020337"],"award-info":[{"award-number":["TYH 2020337"]}]},{"name":"Karolinska Institutet, Sweden","award":["TYH 2022225"],"award-info":[{"award-number":["TYH 2022225"]}]},{"name":"Karolinska Institutet, Sweden","award":["Y2519SU010"],"award-info":[{"award-number":["Y2519SU010"]}]},{"name":"Karolinska Institutet, Sweden","award":["202231103652"],"award-info":[{"award-number":["202231103652"]}]},{"name":"PUSLAPDIK","award":["TYH 2020337"],"award-info":[{"award-number":["TYH 2020337"]}]},{"name":"PUSLAPDIK","award":["TYH 2022225"],"award-info":[{"award-number":["TYH 2022225"]}]},{"name":"PUSLAPDIK","award":["Y2519SU010"],"award-info":[{"award-number":["Y2519SU010"]}]},{"name":"PUSLAPDIK","award":["202231103652"],"award-info":[{"award-number":["202231103652"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Periodontitis is a global health crisis that affects almost half of the world\u2019s population and commonly goes unnoticed because of its asymptomatic and pain-free nature. For early and easy detection and treatment, safe and non-invasive chair-side oral fluid biomarker (aMMP-8) diagnostics and new anti-microbial, anti-inflammatory and anti-proteolytic treatment modalities have been developed, which this review aims to introduce. Methods: For convenient diagnosis and tackling of periodontitis, adoption of an oral fluid aMMP-8 chair-side point-of-care rapid diagnostic test (POCT) has been proposed, comparable to home pregnancy and COVID-19 antigen tests, to be conveniently used by healthcare professionals and by patients themselves. To improve treatment of detected periodontitis, Finnish scientists have also developed a potentially industry-altering, biofilm-modulating, anti-microbial, anti-inflammatory, and anti-proteolytic (i) dual-light-activated photodynamic-therapy (2\u00d7PDT) and (ii) fermented lingonberry juice (FLJ) oral rinse designed for home personalized medicine and professional use. These new oral medicine technologies are reviewed and some unpublished results are presented. Results: aMMP-8 is the superior biomarker for grade of periodontitis (progression rate) when compared to the total latent\/proform MMP-8 (total-MMP-8) and microbial lipopolysaccharide (LPS\/LAL) activity. Cut-off 20 ng\/mL is the optimal cut-off for aMMP-8 POCT and does not make false positives. Antibacterial 2\u00d7 PDT light and anti-microbial FLJ treatments can eliminate and reduce problem-causing bacteria and Candida-yeasts from the mouth. Conclusions: These new oral medicine technologies have shown promising results and could have the potential to revolutionize diagnosis, prevention, oral care, plaque control and maintenance. These new game-changer oral medicine technologies have launched a new clinical field in dentistry: oral clinical chemistry.<\/jats:p>","DOI":"10.3390\/dj13030127","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:16:45Z","timestamp":1741861005000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oral Medicine and Oral Clinical Chemistry Game Changers for Future Plaque Control and Maintenance: PerioSafe\u00ae aMMP-8 POCT, Lumoral\u00ae 2\u00d7 PDT- and Lingora\u00ae Fermented Lingonberry Oral Rinse-Treatments"],"prefix":"10.3390","volume":"13","author":[{"given":"Nur Rahman Ahmad Seno","family":"Aji","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Department of Periodontics, Faculty of Dentistry, Universitas Gadjah Mada, Jalan Denta No. 1 Sekip Utara, 10 Sleman, Yogyakarta 55281, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-8654","authenticated-orcid":false,"given":"Vaibhav","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Research & Evidence (RF&E), New Delhi 110001, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9532-8829","authenticated-orcid":false,"given":"Miika T.","family":"Penttala","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Sakellari","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-2230","authenticated-orcid":false,"given":"Andreas","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology, Dental School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Dental Sector, 424 General Military Training Hospital, 56429 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2219-4689","authenticated-orcid":false,"given":"Tommi","family":"P\u00e4til\u00e4","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Surgery and Organ Transplantation, New Children\u2019s Hospital, University of Helsinki, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2994-8690","authenticated-orcid":false,"given":"Pirjo","family":"P\u00e4rn\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3754-8148","authenticated-orcid":false,"given":"Dirk","family":"Neefs","sequence":"additional","affiliation":[{"name":"Department of Biomedical Surgical and Dental Sciences, Faculty of Medicine and Surgery, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-0887","authenticated-orcid":false,"given":"Andreas","family":"Pf\u00fctzner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Laboratory Medicine, University for Digital Technologies in Medicine and Dentistry, 9516 Wiltz, Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-2459","authenticated-orcid":false,"given":"Shipra","family":"Gupta","sequence":"additional","affiliation":[{"name":"Oral Health Sciences Centre, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"},{"name":"Division of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo T.","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat. 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