{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:32:47Z","timestamp":1780533167707,"version":"3.54.1"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Current Research IRCCS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Objective: The objective of this study is to highlight the critical role of pediatric dentists in promoting oral health prevention among leukemia patients. In fact, oral manifestations frequently serve as the initial clinical indicators of leukemia, occurring in up to 10% of cases. In acute myelomonocytic leukemia, oral lesions are observed in 65\u201390% of patients. Methods: A cohort of 63 patients (30 males and 33 females) with a mean age of 10 years participated in this study. All participants adhered to a standardized preventive dental care protocol, referred to as the \u201cPreventive Iter\u201d. This protocol focuses on individualized oral hygiene education, regular monitoring, and professional dental interventions aimed at preventing and managing oral health complications associated with systemic conditions such as leukemia. Results: The results demonstrated a statistically significant and progressive improvement across all evaluated oral health parameters as patients advanced through the Preventive Iter protocol. Conclusions: The Preventive Iter protocol has proven to be highly effective in improving oral health outcomes, as evidenced by notable reductions in plaque accumulation, microbial imbalance, and gingival inflammation. The structured, individualized approach\u2014incorporating professional hygiene interventions and tailored educational strategies\u2014appears to be a key factor in achieving and maintaining these improvements. These findings underscore the critical importance of early and ongoing preventive care, particularly for medically vulnerable populations.<\/jats:p>","DOI":"10.3390\/dj13040164","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T03:39:16Z","timestamp":1744601956000},"page":"164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Operative Preventive Oral Hygiene Protocols in Pediatric Patients with Leukemia: A Non-Randomized Clinical Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Guido","family":"Galbiati","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Giannini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"del Rosso","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Innovazione Tecnologica, Corso di Laurea in Odontoiatria e Protesi Dentaria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-0585","authenticated-orcid":false,"given":"Maria Grazia","family":"Cagetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-1698","authenticated-orcid":false,"given":"Cinzia","family":"Maspero","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universit\u00e0 degli Studi di Milano, 20122 Milan, Italy"},{"name":"Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/scd.12384","article-title":"Oral and dental management of people with myelodysplastic syndromes and acute myeloid leukemia: A systematic search and evidence-based clinical guidance","volume":"39","author":"Hassan","year":"2019","journal-title":"Spec. 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