{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:58:26Z","timestamp":1777409906508,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: The immune reactions of patients suffering from chronic allergies and asthma are associated with systemic imbalances that may lead to the overexpression of mediators potentially involved in bone remodeling during orthodontic tooth movement. Aim: The aim of this systematic review was to evaluate the existing evidence from animal studies with regard to the effects of allergen sensitization on the phenomena correlated with orthodontically induced tooth movement. Materials and Methods: This systematic review was based on PRISMA 2020 guidelines. A search without restrictions and hand searching were performed from inception to December 2024. The investigation focused on the impact of allergen sensitization on phenomena associated with orthodontic tooth movement. After the retrieval and selection of relevant studies, data extraction was performed, and the data\u2019s risk of bias was evaluated with the SYRCLE\u2019s Risk of Bias Tool. Results: From the detected records, the inclusion criteria were met by only three studies. At the beginning of tooth movement, periodontal ligament was found to be more compressed in the stress area and more stretched in the tension area in sensitized animals. The amount of tooth movement after 14 days of force application was also greater. However, there were conflicting outcomes regarding root resorption. The risk of bias in the retrieved studies was assessed as high overall. Conclusions: Despite the fact that existing evidence is not directly related to human beings and is based on a limited number of animal studies, allergen sensitization could potentially influence the phenomena associated with orthodontic tooth movement, and orthodontists should be aware of the relevant implications.<\/jats:p>","DOI":"10.3390\/dj13040166","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:49:54Z","timestamp":1744714194000},"page":"166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How Does Allergen Sensitization Affect Orthodontic Tooth Movement-Associated Phenomena? A Systematic Review of Animal Studies"],"prefix":"10.3390","volume":"13","author":[{"given":"Fatima Saeed","family":"Bineshaq","sequence":"first","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios E.","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"},{"name":"School of Dentistry, European University Cyprus, 2404 Nicosia, Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-8623","authenticated-orcid":false,"given":"Miltiadis A.","family":"Makrygiannakis","sequence":"additional","affiliation":[{"name":"School of Dentistry, European University Cyprus, 2404 Nicosia, Cyprus"},{"name":"School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-2417","authenticated-orcid":false,"given":"Sotirios","family":"Kalfas","sequence":"additional","affiliation":[{"name":"School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-5110","authenticated-orcid":false,"given":"Eleftherios G.","family":"Kaklamanos","sequence":"additional","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates"},{"name":"School of Dentistry, European University Cyprus, 2404 Nicosia, Cyprus"},{"name":"School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.kjms.2018.01.007","article-title":"Orthodontic tooth movement: The biology and clinical implications","volume":"34","author":"Li","year":"2018","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0022034516677539","article-title":"Cellular and Molecular Pathways Leading to External Root Resorption","volume":"96","author":"Hartsfield","year":"2017","journal-title":"J. Dent. 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