{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:49:28Z","timestamp":1793047768506,"version":"4.5.0"},"reference-count":82,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek","award":["IP-FDMZ-2024.2025-05"],"award-info":[{"award-number":["IP-FDMZ-2024.2025-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting structures, influenced by immune system dysregulation, oxidative stress, and imbalances in bone metabolism. Given its multifactorial pathogenesis, bioactive compounds such as vitamin D, melatonin, and omega-3 fatty acids have emerged as potential adjuncts to periodontal therapy due to their immunomodulatory, anti-inflammatory, and antioxidative properties. This narrative review explores the role of these three supplements in periodontal health, their potential in synergistic effects, and existing research gaps, providing a foundation for future studies on their clinical applications. Vitamin D is essential for calcium homeostasis, bone remodeling, and immune function. It modulates both innate and adaptive immune responses, enhancing antimicrobial peptide production and reducing inflammatory cytokine expression. Omega-3 fatty acids reduce the production of pro-inflammatory eicosanoids while promoting the synthesis of pro-resolving lipid mediators, contributing to bone preservation and immune balance. Melatonin, known for its antioxidant and osteogenic properties, supports bone remodeling by stimulating osteoblast proliferation and inhibiting osteoclast activity, while also regulating circadian rhythms, which may influence oral health. Although these bioactive compounds show promising effects in preclinical and clinical studies, significant knowledge gaps remain regarding optimal dosages, long-term efficacy, combined use, and standardized treatment protocols. Further clinical trials are necessary to elucidate their therapeutic value in periodontal disease management, especially those focused on their potential synergistic mechanisms. Understanding their synergistic mechanisms may open new avenues for adjunctive strategies in periodontal therapy.<\/jats:p>","DOI":"10.3390\/dj13040178","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:15:06Z","timestamp":1745180106000},"page":"178","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4905-067X","authenticated-orcid":false,"given":"Dora","family":"Dragi\u010devi\u0107 Tomi\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina","family":"Le\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"\u0160krlec","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Biology and Chemistry, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-1124","authenticated-orcid":false,"given":"Larissa","family":"Steigmann","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Tseneva","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"\u010calu\u0161i\u0107 \u0160arac","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"},{"name":"Health Center of Osijek-Baranja County, Park Kralja Petra Kre\u0161imira IV 6, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-9066","authenticated-orcid":false,"given":"Tin","family":"Crni\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Operative Dentistry, University of Mainz, Augustusplatz 2, 55131 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Tomi\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"},{"name":"Health Center of Osijek-Baranja County, Park Kralja Petra Kre\u0161imira IV 6, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka","family":"Peri\u0107 Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"},{"name":"Department of Anatomy, Histology, Embriology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7157","authenticated-orcid":false,"given":"Marija","family":"\u010candrli\u0107","sequence":"additional","affiliation":[{"name":"Department of Integrative Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0757.2010.00347.x","article-title":"Mechanisms and Control of Pathologic Bone Loss in Periodontitis","volume":"53","author":"Bartold","year":"2010","journal-title":"Periodontol 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrendo.2016.91","article-title":"Physiological and Pathophysiological Bone Turnover\u2014Role of the Immune System","volume":"12","author":"Weitzmann","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bacali, C., Vulturar, R., Buduru, S., Cozma, A., Fodor, A., Chi\u0219, A., Lucaciu, O., Damian, L., and Moldovan, M.L. (2022). 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