{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:46:00Z","timestamp":1780944360159,"version":"3.54.1"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARDEC Academy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: The combination of polynucleotides and hyaluronic acid with bovine bone grafts in maxillary sinus lift procedures appears to be a promising strategy to enhance bone regeneration. This study aimed to analyze implant osseointegration, bone repair and sinus mucosa integrity using Bio-Oss\u00ae and Hyaluronic Acid-Polynucleotide Gel (Regenfast\u00ae) in maxillary sinus augmentation in rabbits. Methods: Sinus floor elevation was performed in 12 rabbits, with one implant placed per sinus simultaneously. In the control group, sinuses were grafted with deproteinized bovine bone mineral (Bio-Oss\u00ae) alone; in the test group, Bio-Oss\u00ae was combined with Regenfast\u00ae. Two histological slides were obtained per sinus after 2 weeks (six animals) and 10 weeks (six animals): one from the grafted area alone (non-implant sites), and one from the implant site. Primary outcome variables included the percentage of newly formed bone, the extent of implant osseointegration, and the number of sinus mucosa perforations caused by contact with graft granules. Results: After 10 weeks of healing, the test group showed a significantly higher percentage of new bone formation (37.2 \u00b1 6.7%) compared to the control group (26.8 \u00b1 10.0%; p = 0.031); osseointegration extended to the implant apex in both groups; fewer sinus mucosa perforations were observed in the test group (n = 5) than in the control group (n = 14). Conclusions: The addition of Regenfast\u00ae to Bio-Oss\u00ae granules promoted enhanced bone regeneration within the elevated sinus area and was associated with a lower incidence of sinus membrane perforations compared to the use of Bio-Oss\u00ae alone.<\/jats:p>","DOI":"10.3390\/dj13070293","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:37:51Z","timestamp":1751283471000},"page":"293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss\u00ae and Hyaluronic Acid-Polynucleotide Gel (Regenfast\u00ae) in Maxillary Sinus Augmentation in Rabbits"],"prefix":"10.3390","volume":"13","author":[{"given":"Hiroyuki","family":"Omori","sequence":"first","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"Ardec Academy, 47923 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3657-384X","authenticated-orcid":false,"given":"Erick Ricardo","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9-Subsetor Oeste 11 (N-11), Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-5886","authenticated-orcid":false,"given":"Samuel Porfirio","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9-Subsetor Oeste 11 (N-11), Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Luis Scombatti de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9-Subsetor Oeste 11 (N-11), Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.11607\/prd.1288","article-title":"Long-term implant survival in the grafted maxillary sinus: A systematic review","volume":"33","author":"Wallace","year":"2013","journal-title":"Int. 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Implant."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/7\/293\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:00:44Z","timestamp":1760032844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/7\/293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["dj13070293"],"URL":"https:\/\/doi.org\/10.3390\/dj13070293","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]}}}