{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:10:16Z","timestamp":1789578616236,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Dental anxiety often poses a significant barrier to effective dental care in pediatric patients. This study evaluated the efficacy and safety of oral midazolam at two different doses for sedation and amnesia in preschool children undergoing dental procedures under 30 min, including primary teeth extraction, root canal treatment, dental filling, and stainless-steel crown. Methods: This prospective, double-blind, randomized controlled trial included 80 children aged 3\u20136 years with dental anxiety (Types 1 and 2 of the Frankl Behavior Rating Scale) at the National Hospital of Odonto-Stomatology, Hanoi. following the CONSORT guidelines. Participants were randomly assigned to receive oral midazolam at 0.3 mg\/kg or 0.6 mg\/kg. Sedation efficacy, onset time, procedure duration, cooperation level (Houpt Behavior Rating Scale), recovery time, and amnesia at 12 h, 24 h, and 1 week, as well as adverse events, were recorded and analyzed. Results: Both midazolam doses were effective for sedation (0.3 mg\/kg: 95% vs. 0.6 mg\/kg: 100%, p = 0.49). The higher dose (0.6 mg\/kg) provided significantly longer effective procedural time (27.3 \u00b1 4.1 min vs. 20.3 \u00b1 4.0 min, p &lt; 0.001) and better patient cooperation (95% vs. 78.9%, p = 0.045), but slightly prolonged recovery time (34.6 \u00b1 4.6 min vs. 31.8 \u00b1 4.4 min, p = 0.008). Both doses produced similar amnesic effects, with approximately 90% anterograde amnesia at 12 h post-procedure. Adverse events were minimal and mild. Conclusions: Both 0.3 mg\/kg and 0.6 mg\/kg doses of oral midazolam are safe and effective for sedation and amnesia in preschool children undergoing dental procedures. While the 0.6 mg\/kg dose provides better procedural cooperation and prolonged sedation, it also requires a slightly longer recovery time.<\/jats:p>","DOI":"10.3390\/dj13070308","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:38:27Z","timestamp":1752140307000},"page":"308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Oral Midazolam for Sedation and Amnesia in Preschool Children with Dental Anxiety: A Double-Blind, Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Nguyen Quang","family":"Binh","sequence":"first","affiliation":[{"name":"National Hospital of Odonto-Stomatology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Truong Nhu","family":"Ngoc","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Quoc","family":"Khanh","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"National Children\u2019s Hospital, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-8671","authenticated-orcid":false,"given":"Nguyen Phuong","family":"Huyen","sequence":"additional","affiliation":[{"name":"National Hospital of Odonto-Stomatology, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh Khanh","family":"Linh","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hanoi Medical University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Phuc","family":"Khanh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Medicine and Pharmacy-Vietnam National University, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7872-9291","authenticated-orcid":false,"given":"Le Kha","family":"Anh","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hanoi Medical University, Hanoi 100000, Vietnam"},{"name":"Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/ipd.12712","article-title":"Prevalence of dental anxiety in children and adolescents globally: A systematic review with meta-analyses","volume":"31","author":"Grisolia","year":"2021","journal-title":"Int. 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