{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:22:01Z","timestamp":1787984521506,"version":"build-2784847793"},"reference-count":80,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RUDN University Strategic Academic Leadership Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Periodontitis (PD), is a chronic inflammatory disease of the periodontal system, which includes gingiva, periodontal ligament, alveolar bone, and tooth cement. It is becoming increasingly prevalent globally, and its implications for oral health are profound. The Nrf2 signaling pathway is crucial in managing the relationship between inflammation and oxidative stress, making it vital for understanding this disease. Nrf2 interacts with key redox-sensitive inflammatory pathways, playing a vital role in the development of periodontitis. Acknowledging these dynamics underscores the importance of proactively addressing the complex aspects of periodontal disease. This review emphasizes its intricate interactions with redox-sensitive transcription factors vital for sustaining the self-perpetuating inflammatory processes underlying the disease. Additionally, it explores promising therapeutic strategies aimed at Nrf2 activation and encourages more effective management of PD.<\/jats:p>","DOI":"10.3390\/dj13070314","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:46:33Z","timestamp":1752237993000},"page":"314","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Activation of the Nrf2 Signaling Pathway as a Therapeutic Strategy Against Periodontal Disease: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5324-1957","authenticated-orcid":false,"given":"Sarmistha","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura 281406, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1100-929X","authenticated-orcid":false,"given":"Nadezhda","family":"Sachivkina","sequence":"additional","affiliation":[{"name":"Department of Microbiology V.S. Kiktenko, Institute of Medicine, Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Lenchenko","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Russian Biotechnological University (BIOTECH University), 125080 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8171-3665","authenticated-orcid":false,"given":"Olga","family":"Pilshchikova","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Dentistry, Institute of Medicine, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3982-5512","authenticated-orcid":false,"given":"Alexandr","family":"Muraev","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Medicine, Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba (RUDN University), 117198 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Inanc, N., Mumcu, G., Can, M., Yay, M., Silbereisen, A., Manoil, D., Direskeneli, H., and Bostanci, N. 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