{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:45:23Z","timestamp":1790246723716,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological Development\/Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["302999\/2024-8"],"award-info":[{"award-number":["302999\/2024-8"]}]},{"name":"National Council for Scientific and Technological Development\/Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["302545\/2025-5"],"award-info":[{"award-number":["302545\/2025-5"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>This review aims to provide an overview of the role of vitamin D in peri-implant and periodontal tissue. Electronic searches were carried out of the PubMed\/Medline database. Since this is a narrative review, no systematic search, meta-analysis, or statistical analysis was performed. Vitamin D plays a crucial role in bone balance and metabolism, contributing to reducing early implant failure and improving dental implant osseointegration. Vitamin D deficiency poses a challenge to clinical outcomes, and its supplementation can be an effective alternative to overcome this limitation. The results reported in this article show that vitamin D application on implants can improve the osseointegration, bone-to-implant contact, implant stability, and bone density. Moreover, vitamin D supplementation can increase RUNX2, ALP, OPN, and OCN expression, contributing to periodontal tissue health and its regeneration. Together, findings provide an overview of these topics and present future perspectives for clinical practice in dentistry.<\/jats:p>","DOI":"10.3390\/dj13100448","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T09:12:23Z","timestamp":1759223543000},"page":"448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D in Peri-Implant and Periodontal Tissue"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-6873","authenticated-orcid":false,"given":"Felipe de Souza","family":"Duarte","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-6360","authenticated-orcid":false,"given":"Nath\u00e1lia Dantas","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Mulinari-Santos","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-5093","authenticated-orcid":false,"given":"Paula Buzo","family":"Frig\u00e9rio","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba School of Dentistry (FOA-UNESP), S\u00e3o Paulo State University, Ara\u00e7atuba 16015-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-2218","authenticated-orcid":false,"given":"Rogerio Leone","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry (FOB-USP), University of S\u00e3o Paulo, Bauru 17012-901, Brazil"},{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Sciences, University of S\u00e3o Paulo (FMVZ-USP), S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9914-1262","authenticated-orcid":false,"given":"Daniela Vieira","family":"Buchaim","sequence":"additional","affiliation":[{"name":"Graduate Program in Anatomy of Domestic and Wild Animals, School of Veterinary Medicine and Animal Sciences, University of S\u00e3o Paulo (FMVZ-USP), S\u00e3o Paulo 05508-270, Brazil"},{"name":"Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil"},{"name":"Department of Postgraduate, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-0795","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Mardegan","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, Ribeir\u00e3o Preto School of Dentistry (FORP-USP), University of S\u00e3o Paulo, Ribeir\u00e3o Preto 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S346","DOI":"10.4103\/jpbs.jpbs_543_22","article-title":"Assessment of Outcome of Oral Supplementation of Vitamin D3 as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients with Type II Diabetes Mellitus\u2014A Randomized Controlled Clinical Trial","volume":"15","author":"Ramaprabha","year":"2023","journal-title":"J. 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