{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:16:20Z","timestamp":1769922980492,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome which often leads to progressive muscular dysfunction and therefore oral health deterioration. The aim of this scoping review is to evaluate oral health status in ALS patients focusing on the importance of dental care in improving patient\u2019s quality of life. Methods: A comprehensive literature search was conducted on PubMed, Scopus, Web of Science, and Embase databases until June 2025 using a combination of keywords and MeSH terms related to ALS and oral health. Studies were screened and selected based on inclusion and exclusion criteria, focusing on human clinical data reporting oral health outcomes in ALS. Results: Eight studies met the inclusion criteria. The findings showed a high prevalence of oral complications in bulbar-onset ALS patients. Common issues included reduced tongue mobility, poor oral hygiene, sialorrhea, and decreased masticatory function were evaluated. Conclusions: Oral health impairment in ALS patients frequently contributes to systemic risks and reduced quality of life. A dental expert may play an important role in multidisciplinary care teams in terms of early diagnosis and conservative treatment of oral diseases ranging from periodontal disease to temporomandibular disorders (TMD). Personalized oral hygiene strategies and adjunctive therapies may serve as key elements in maintaining overall health and patient comfort in ALS. Therefore, the objective of the following review was to evaluate oral health complication in patients with ALS, highlighting the impact of oral care on patients\u2019 quality of life.<\/jats:p>","DOI":"10.3390\/dj13100455","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:22:47Z","timestamp":1759483367000},"page":"455","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Health Status in Patients with Amyotrophic Lateral Sclerosis: A Scoping Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4723-3360","authenticated-orcid":false,"given":"Leopoldo","family":"Mauriello","sequence":"first","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-5139","authenticated-orcid":false,"given":"Alessandro","family":"Cuozzo","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-3270","authenticated-orcid":false,"given":"Vitolante","family":"Pezzella","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"Unit of Periodontology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95124 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-9786","authenticated-orcid":false,"given":"Gianrico","family":"Spagnuolo","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"Therapeutic Dentistry Department, Institute for Dentistry, Sechenov University, Moscow 119991, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Iorio-Siciliano","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1121-121X","authenticated-orcid":false,"given":"Luca","family":"Ramaglia","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8794","authenticated-orcid":false,"given":"Andrea","family":"Blasi","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nrl.2015.12.001","article-title":"Why Do Motor Neurons Degenerate? Actualisation in the Pathogenesis of Amyotrophic Lateral Sclerosis","volume":"34","author":"Riancho","year":"2019","journal-title":"Neurolog\u00eda"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sycinska-Dziarnowska, M., Maglitto, M., Wo\u017aniak, K., and Spagnuolo, G. (2021). Oral Health and Teledentistry Interest during the Covid-19 Pandemic. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163532"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/1874210601711010621","article-title":"Correlation Between Metabolic Syndrome, Periodontitis and Reactive Oxygen Species Production. A Pilot Study","volume":"11","author":"Patini","year":"2017","journal-title":"Open Dent. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000351153","article-title":"Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature","volume":"41","author":"Logroscino","year":"2013","journal-title":"Neuroepidemiology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/0022034516682718","article-title":"A New Definition for Oral Health: Implications for Clinical Practice, Policy and Research","volume":"96","author":"Lee","year":"2017","journal-title":"J. Dent. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/jcpe.13769","article-title":"Prevalence of Periodontitis in Dentate People between 2011 and 2020: A Systematic Review and Meta-Analysis of Epidemiological Studies","volume":"50","author":"Trindade","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jgs.16154","article-title":"The Prevention of Infections in Older Adults: Oral Health","volume":"68","author":"Coll","year":"2020","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","article-title":"Dental Caries","volume":"369","author":"Selwitz","year":"2007","journal-title":"Lancet"},{"key":"ref_9","first-page":"e43","article-title":"Periodontitis and Alzheimers Disease","volume":"26","year":"2021","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1111\/jcpe.12089","article-title":"Periodontitis and Atherosclerotic Cardiovascular Disease: Consensus Report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"40","author":"Tonetti","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/scd.12636","article-title":"Oral Hygiene in Patients with Motor Neuron Disease Requires Attention: A Cross-Sectional Survey Study","volume":"42","author":"Makizodila","year":"2022","journal-title":"Spec. Care Dent."},{"key":"ref_13","first-page":"e50602","article-title":"Dental Management of Patients with Amyotrophic Lateral Sclerosis","volume":"15","author":"AlMadan","year":"2023","journal-title":"Cureus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/00016357.2017.1420228","article-title":"Oral Health Status of Hospitalized Amyotrophic Lateral Sclerosis Patients: A Single-Centre Observational Study","volume":"76","author":"Nakayama","year":"2018","journal-title":"Acta Odontol. Scand."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00016357.2016.1276212","article-title":"Orofacial Function and Monitoring of Oral Care in Amyotrophic Lateral Sclerosis","volume":"75","author":"Bergendal","year":"2017","journal-title":"Acta Odontol. Scand."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1016\/j.jpainsymman.2021.12.005","article-title":"Prevalence of Sialorrhea Among Amyotrophic Lateral Sclerosis Patients: A Systematic Review and Meta-Analysis","volume":"63","author":"Wang","year":"2022","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/mus.20545","article-title":"Botulinum Toxin Improves Sialorrhea and Quality of Living in Bulbar Amyotrophic Lateral Sclerosis","volume":"34","author":"Verma","year":"2006","journal-title":"Muscle Nerve"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/joor.12597","article-title":"Functional Limitation of the Masticatory System in Patients with Bulbar Involvement in Amyotrophic Lateral Sclerosis","volume":"45","author":"Willaert","year":"2018","journal-title":"J. Oral. Rehabil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.11607\/ofph.1882","article-title":"Alterations in the Masticatory System in Patients with Amyotrophic Lateral Sclerosis","volume":"32","author":"Paipa","year":"2018","journal-title":"J. Oral. Facial Pain. Headache"},{"key":"ref_20","first-page":"49","article-title":"Functional Status and Oral Health in Patients with Amyotrophic Lateral Sclerosis: A Cross-Sectional Study","volume":"48","author":"Invernizzi","year":"2021","journal-title":"NeuroRehabilitation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/adj.12195","article-title":"Oral Health and Dental Treatment Needs of People with Motor Neurone Disease","volume":"59","author":"Tay","year":"2014","journal-title":"Aust. Dent. J."},{"key":"ref_22","first-page":"127","article-title":"Dysarthria and Dysphagia in Amyotrophic Lateral Sclerosis with Spinal Onset: A Study of Quality of Life Related to Swallowing","volume":"36","year":"2015","journal-title":"NeuroRehabilitation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/joor.12019","article-title":"Oropharyngeal Dysphagia in Amyotrophic Lateral Sclerosis Alters Quality of Life","volume":"40","author":"Paris","year":"2013","journal-title":"J. Oral. Rehabil."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic Lateral Sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Oh, J., An, J., Park, K., and Park, Y. (2024). Psychosocial Interventions for People with Amyotrophic Lateral Sclerosis and Motor Neuron Disease and Their Caregivers: A Scoping Review. BMC Nurs., 23.","DOI":"10.1186\/s12912-024-01721-6"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/mus.21213","article-title":"Randomized Double-Blind Study of Botulinum Toxin Type B for Sialorrhea in ALS Patients","volume":"39","author":"Jackson","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/jnnp.69.1.121","article-title":"V Injections of Botulinum Toxin A into the Salivary Glands Improve Sialorrhoea in Amyotrophic Lateral Sclerosis","volume":"69","author":"Giess","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_28","first-page":"CD006981","article-title":"Treatment for Sialorrhea (Excessive Saliva) in People with Motor Neuron Disease\/Amyotrophic Lateral Sclerosis","volume":"5","author":"James","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.apcsb.2019.12.001","article-title":"Roles of Porphyromonas Gingivalis and Its Virulence Factors in Periodontitis","volume":"120","author":"Xu","year":"2020","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Santonocito, S., Giudice, A., Polizzi, A., Troiano, G., Merlo, E.M., Sclafani, R., Grosso, G., and Isola, G. (2022). A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System\u2019s Response during Periodontitis. Nutrients, 14.","DOI":"10.3390\/nu14122426"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jns.2008.12.027","article-title":"Do Patients with Amyotrophic Lateral Sclerosis (ALS) Have Increased Energy Needs?","volume":"279","author":"Vaisman","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Pezzella, V., Cuozzo, A., Mauriello, L., Polizzi, A., Iorio Siciliano, V., Ramaglia, L., and Blasi, A. (2025). Propolis as an Adjunct in Non-Surgical Periodontal Therapy: Current Clinical Perspectives from a Narrative Review. J. Funct. Biomater., 16.","DOI":"10.3390\/jfb16070265"},{"key":"ref_33","first-page":"310","article-title":"Non-Surgical Treatment of Moderate Periodontal Intrabony Defects with Adjunctive Cross-Linked Hyaluronic Acid: A Single-Blinded Randomized Controlled Clinical Trial","volume":"52","author":"Blasi","year":"2024","journal-title":"J. Clin. Periodontol."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/10\/455\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:30:56Z","timestamp":1759483856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/13\/10\/455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["dj13100455"],"URL":"https:\/\/doi.org\/10.3390\/dj13100455","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]}}}