{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T04:22:44Z","timestamp":1761366164065,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016991","name":"Universidad de Guadalajara","doi-asserted-by":"crossref","award":["2955274-PROSNII"],"award-info":[{"award-number":["2955274-PROSNII"]}],"id":[{"id":"10.13039\/100016991","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CONACyT-SECIHTI-Mexico","award":["CVU 1254496"],"award-info":[{"award-number":["CVU 1254496"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Hemophilic pseudotumor (HP) is a rare but severe complication of hemophilia, characterized by progressive bleeding in the muscles, joints, and bone tissue, which can lead to lytic lesions. Its prevalence is approximately 1\u20132% among patients with hemophilia. This report presents a male patient with mild hemophilia A who developed an intraosseous lesion in the posterior region of the right maxilla, with a prior history of endodontic treatment in the area. Surgical excision was performed and, following clinicopathological correlation, the lesion was diagnosed as HP. Background\/Objectives: This review aims to identify previously reported cases of HP located in the maxilla. Methods: The study protocol followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines. The databases PubMed, Scopus, and ScienceDirect were searched, and Google Scholar was used to identify gray literature. The Joanna Briggs Institute (JBI) tool was employed to assess the risk of bias and the quality of the included reports and case series. Results: A total of 1487 publications were identified using specific keywords. After removing duplicates and non-relevant titles\/abstracts, 42 full-text articles were reviewed. Of these, 10 met the inclusion criteria: 7 case reports and 3 case series, comprising 13 cases of HP in the maxilla, including the case presented here. Although rare in the maxillofacial region, when it does occur, it is more commonly seen in the mandible and is often linked to prior trauma. In this case, endodontic treatment may have triggered lesion development. Conclusions: This report highlights that, although uncommon, HP can manifest with involvement of the maxilla, and that specific dental interventions may represent potential triggering events.<\/jats:p>","DOI":"10.3390\/dj13110491","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T01:35:11Z","timestamp":1761269711000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemophilic Pseudotumor of the Maxilla Secondary to Endodontic Treatment: Case Report and Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0602-7394","authenticated-orcid":false,"given":"Jose Rodolfo","family":"Quiroz-Gomez","sequence":"first","affiliation":[{"name":"Master\u2019s Program in Oral Pathology and Medicine, Department of Integral Dental Clinics, University Center of Health Sciences, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Manuel","family":"Roa-Encarnaci\u00f3n","sequence":"additional","affiliation":[{"name":"High Specialty Medical Unit\u2014Pediatrics, National Medical Center of the West, Instituto Mexicano del Seguro Social, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-6504","authenticated-orcid":false,"given":"Ana Graciela","family":"Puebla-Mora","sequence":"additional","affiliation":[{"name":"Pathology Research and Diagnostic Center, Department of Microbiology and Pathology, University Center of Health Sciences, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-9249","authenticated-orcid":false,"given":"Antonio","family":"Hern\u00e1ndez-Morales","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of the Mexico State, Toluca de Lerdo 50130,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Padilla-Rosas","sequence":"additional","affiliation":[{"name":"Master\u2019s Program in Oral Pathology and Medicine, Department of Integral Dental Clinics, University Center of Health Sciences, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-8521","authenticated-orcid":false,"given":"Mario","family":"Nava-Villalba","sequence":"additional","affiliation":[{"name":"Pathology Research and Diagnostic Center, Department of Microbiology and Pathology, University Center of Health Sciences, Universidad de Guadalajara, Guadalajara 44340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/hae.13870","article-title":"Characteristics and management of the haemophilia-associated pseudotumours","volume":"26","author":"Doyle","year":"2020","journal-title":"Haemophilia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/MPH.0b013e3181758926","article-title":"Maxillary hemophilic pseudotumor in a patient with mild hemophilia A","volume":"30","year":"2008","journal-title":"J. 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