{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:39:05Z","timestamp":1787027945030,"version":"build-2736575974"},"reference-count":67,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Purgo Biologics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Maxillary sinus floor augmentation is widely used to enable implant placement in the atrophic posterior maxilla, yet comparative data for porcine-derived xenografts remain limited. Objective: To evaluate long-term bone regeneration and implant outcomes following sinus augmentation using a collagenated porcine xenograft. Methods: This paper reports a retrospective case series of three partially edentulous patients (aged 46\u201356 years) who underwent lateral sinus augmentation with a small-particle collagenated porcine xenograft (THE Graft\u2122, Purgo Biologics, Gyeonggi-do, Republic of Korea) and staged implant placement. In one case, a controlled perforation of the Schneiderian membrane was performed to access and remove a sinus mucocele, followed by repair using a resorbable collagen membrane. Core biopsies were harvested at implant placement for histology (hematoxylin-eosin, Masson\u2013Goldner) and tartrate-resistant acid phosphatase (TRAP) staining. Clinical outcomes included surgical events, vertical bone gain, marginal bone levels, and implant survival at long-term follow-up. Results: Healing was uneventful in all cases. Mean vertical bone gain was 12.0 mm (baseline 1.33 mm to 13.33 mm final). At a mean 46.8-month follow-up (range 38.3\u201352.2 months), 100% of implants were functional without failure; marginal bone loss remained &lt; 1 mm during the first year and was stable thereafter. Histology at 3.7, 4.7, and 7.5 months showed vascularized new trabecular bone intimately contacting residual xenograft particles (new bone 20\u201330%, residual biomaterial 30\u201340%, connective tissue 30\u201350%). TRAP-positive multinucleated giant cells at 7.5 months indicated ongoing biomaterial degradation without severe inflammatory reactions. Conclusions: Within the limits of a small case series, collagenated porcine xenograft supported predictable bone regeneration and stable long-term implant function after sinus floor elevation, with favorable histologic integration and gradual resorption.<\/jats:p>","DOI":"10.3390\/dj13120584","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T16:37:02Z","timestamp":1764952622000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sinus Lift with Collagenated Porcine Xenograft in Severely Atrophic Posterior Maxillae: Case Series with Histologic Correlation and Long-Term Outcomes"],"prefix":"10.3390","volume":"13","author":[{"given":"Alexandru","family":"Sp\u00eenu","sequence":"first","affiliation":[{"name":"Doctoral School, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"},{"name":"Spinu Dental Clinic, Spinu Learning, 410155 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-1148","authenticated-orcid":false,"given":"Felicia","family":"Manole","sequence":"additional","affiliation":[{"name":"Surgical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-7595","authenticated-orcid":false,"given":"Alexandru","family":"Burcea","sequence":"additional","affiliation":[{"name":"Department of Speciality Disciplines, \u201cTitu Maiorescu\u201d University, 031593 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-149X","authenticated-orcid":false,"given":"Cristina-Crengu\u0163a","family":"Albu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Dentistry, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia-Florica","family":"M\u0103rcu\u021b","sequence":"additional","affiliation":[{"name":"Surgical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana Daniela","family":"Brata","sequence":"additional","affiliation":[{"name":"Medical Disciplines Department, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3410-3870","authenticated-orcid":false,"given":"Alexia","family":"Manole","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-893X","authenticated-orcid":false,"given":"Claudia Florina","family":"Bogdan-Andreescu","sequence":"additional","affiliation":[{"name":"Department of Speciality Disciplines, \u201cTitu Maiorescu\u201d University, 031593 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"ref_1","first-page":"147","article-title":"Maxillary sinus implications in endodontics and implant dentistry\u2014A literature review","volume":"16","author":"Iliescu","year":"2024","journal-title":"Rom. 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