{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:28:56Z","timestamp":1773746936001,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Lithium disilicate (LD) veneers are widely used for minimally invasive anterior rehabilitation because of their favorable optical and mechanical properties. Fully digital workflows have been proposed as alternatives to conventional milling. These approaches combine computer-aided design and manufacturing (CAD\/CAM) with 3D-printed burn-out patterns and subsequent heat pressing of LD ingots. However, clinical documentation of multi-unit anterior cases fabricated exclusively through this additive-plus-pressing route remains scarce. This case report aims to describe a fully digital additive-plus-pressing workflow for four maxillary anterior LD veneers and to report 48-month clinical outcomes. Case Presentation: A 52-year-old female presented with esthetic concerns involving the maxillary central and lateral incisors (teeth 11, 12, 21, and 22). After clinical and radiographic evaluation, a minimally invasive veneer-based rehabilitation was planned. Preparations were performed under magnification, and immediate dentin sealing was applied. Digital impressions were obtained with an intraoral scanner, and veneers were designed using CAD software(Exocad DentalDB 3.0 Galway (Exocad GmbH, Darmstadt, Germany). Castable resin patterns were 3D-printed, invested, and heat-pressed using LD ingots, followed by finishing and glazing. Adhesive cementation was performed under rubber dam isolation after hydrofluoric acid etching and silanization of the intaglio surfaces and conditioning of the tooth substrates according to the adhesive protocol, using a dual-cure resin cement. At the 48-month follow-up, all veneers remained intact, with clinically acceptable marginal adaptation, stable color and surface gloss, and no signs of secondary caries or marginal discoloration. The patient reported sustained esthetic satisfaction and comfortable function without postoperative sensitivity. Conclusions: This single-patient report suggests that a fully digital additive-plus-pressing workflow may be clinically viable for high-demand anterior LD veneers, providing favorable medium-term esthetics and patient-centered outcomes with no technical or biological complications. The reproducible protocol described may facilitate the integration of 3D printing and heat pressing into digital veneer rehabilitation and supports further controlled clinical investigations.<\/jats:p>","DOI":"10.3390\/dj14030175","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:21:41Z","timestamp":1773742901000},"page":"175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four-Year Outcomes of Anterior Pressed Lithium Disilicate Veneers Fabricated from 3D-Printed Burn-Out Patterns: A Clinical Case Report"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9902-4976","authenticated-orcid":false,"given":"Suria Sarahi","family":"Oliver-Rivas","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Roberto","family":"Luna-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Oliver-Parra","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo De Jesus","family":"Figueroa-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo Alberto Salvador","family":"Gomez Lara","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-3860","authenticated-orcid":false,"given":"Jorge Humberto","family":"Luna-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad esq. con Blvd. Adolfo L\u00f3pez Mateos s\/n, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bernauer, S.A., M\u00fcller, J., Zitzmann, N.U., and Joda, T. (2020). Influence of preparation design, marginal gingiva location, and tooth morphology on the accuracy of digital impressions for full-crown restorations: An in vitro investigation. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123984"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/jerd.13028","article-title":"CAD-CAM natural restorations-Reproducing nature using a digital workflow","volume":"35","author":"Segundo","year":"2023","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.jds.2021.04.005","article-title":"Tooth preparation, digital design and milling process considerations for CAD\/CAM crowns: Understanding the transition from analog to digital workflow","volume":"16","author":"Turkyilmaz","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41368-019-0057-y","article-title":"Minimal invasive microscopic tooth preparation in esthetic restoration: A specialist consensus","volume":"11","author":"Yu","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/00220345221142755","article-title":"A critical review of dental lithia-based glass-ceramics","volume":"102","author":"Zhang","year":"2023","journal-title":"J. Dent. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1002\/cre2.761","article-title":"Resin cement selection for different types of fixed partial coverage restorations: A narrative systematic review","volume":"9","author":"Ghodsi","year":"2023","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_7","first-page":"e65534","article-title":"A comparative evaluation of the bonding strength, marginal adaptation, and microleakage of dental cements in prosthodontics: An in vitro comparative study","volume":"16","author":"Vyas","year":"2024","journal-title":"Cureus"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.prosdent.2018.11.024","article-title":"Ten-year survival of pressed, acid-etched e.max lithium disilicate monolithic and bilayered complete-coverage restorations: Performance and outcomes as a function of tooth position and age","volume":"121","author":"Malament","year":"2019","journal-title":"J. Prosthet. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1007\/s00784-023-05328-0","article-title":"Retrospective clinical study on the performance and aesthetic outcome of pressed lithium disilicate restorations in posterior teeth up to 8.3 years","volume":"27","author":"Lindner","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ispas, A., Moldovan, M., Cuc, S., Prodan, D., Bacali, C., Petean, I., Buduru, S., Manziuc, M., and Iosif, L. (2023). SEM evaluation of marginal adaptation E-Max crowns manufactured by printing-pressed and milling. Diagnostics, 13.","DOI":"10.3390\/diagnostics13233518"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Patel, T., Nathwani, N., Fine, P., and Leung, A. (2022). A scoping review of marginal and internal fit accuracy of lithium disilicate restorations. Dent. J., 10.","DOI":"10.3390\/dj10120236"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.17126\/joralres.2024.037","article-title":"Effect of laboratory workflow on the internal fit of pressed lithium disilicate restorations","volume":"13","author":"Luengo","year":"2024","journal-title":"J. Oral Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"104181","DOI":"10.1016\/j.jdent.2022.104181","article-title":"CAD\/CAM versus 3D-printing\/pressed lithium disilicate monolithic crowns: Adaptation and fatigue behavior","volume":"123","author":"Ottoni","year":"2022","journal-title":"J. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.prosdent.2020.07.007","article-title":"Marginal and internal adaptation of single crowns and fixed dental prostheses by using digital and conventional workflows: A systematic review and meta-analysis","volume":"126","author":"Hasanzade","year":"2021","journal-title":"J. Prosthet. Dent."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cant\u00f3-Nav\u00e9s, O., Michels, K., Figueras-\u00c1lvarez, O., Fern\u00e1ndez-Villar, S., Cabratosa-Termes, J., and Roig, M. (2023). In vitro comparison of internal and marginal adaptation between printed and milled onlays. Materials, 16.","DOI":"10.3390\/ma16216962"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1055.e1","DOI":"10.1016\/j.prosdent.2024.12.023","article-title":"Effects of preparation design on the marginal and internal fit of CAD-CAM overlay restorations: A \u00b5CT evaluation","volume":"133","author":"Mancuso","year":"2025","journal-title":"J. Prosthet. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/jerd.13155","article-title":"3D printing of ultra-thin veneers made of lithium disilicate using the LCM method in a digital workflow: A feasibility study","volume":"36","author":"Schweiger","year":"2024","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/prosthesis6020025","article-title":"A randomized controlled clinical trial on lithium disilicate veneers manufactured by the CAD-CAM method: Digital versus hybrid workflow","volume":"6","author":"Verniani","year":"2024","journal-title":"Prosthesis"},{"key":"ref_19","first-page":"54","article-title":"A retrospective clinical study on 1075 lithium disilicate CAD\/CAM veneers with feather-edge margins cemented on 105 patients","volume":"29","author":"Imburgia","year":"2021","journal-title":"Eur. J. Prosthodont. Restor. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"M\u0103roiu, A.-C., Sinescu, C., Duma, V.-F., Topal\u0103, F., Jiv\u0103nescu, A., Popovici, P.M., Tudor, A., and Rom\u00eenu, M. (2021). Micro-CT and microscopy study of internal and marginal gap to tooth surface of crenelated versus conventional dental indirect veneers. Medicina, 57.","DOI":"10.3390\/medicina57080772"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hardan, L., Devoto, W., Bourgi, R., Cuevas-Su\u00e1rez, C.E., Lukomska-Szymanska, M., Fern\u00e1ndez-Barrera, M.\u00c1., Cornejo-R\u00edos, E., Monteiro, P., Zarow, M., and Jakubowicz, N. (2022). Immediate dentin sealing for adhesive cementation of indirect restorations: A systematic review and meta-analysis. Gels, 8.","DOI":"10.3390\/gels8030175"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.prosdent.2024.03.014","article-title":"Clinical benefits of immediate dentin sealing: A systematic review and meta-analysis","volume":"134","author":"Alghauli","year":"2025","journal-title":"J. Prosthet. Dent."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"482","DOI":"10.61872\/sdj-2022-07-08-877","article-title":"Effect of immediate dentin sealing on the fracture strength of lithium disilicate ceramic onlays","volume":"132","author":"Saadeddin","year":"2022","journal-title":"Swiss Dent. J."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/3\/175\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:45:48Z","timestamp":1773744348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/3\/175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["dj14030175"],"URL":"https:\/\/doi.org\/10.3390\/dj14030175","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}