{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:17:10Z","timestamp":1778145430584,"version":"3.51.4"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Residual EDTA may persist after smear-layer removal and after the application of contact sealers during setting. This in vitro study compared the effect of 1 min of pre-setting surface contact with 17% EDTA (vs. distilled water) on a calcium silicate-based sealer (AH Plus Bioceramic Sealer) and an epoxy resin-based sealer (AH Plus). Methods: Discs were prepared (N = 108) in a 2 \u00d7 2 design (n = 27\/group); per group; n = 12 were used for solubility followed by eluate pH using the same specimens\/eluates after 24 h immersion in distilled water; n = 12 were used to test Vickers microhardness on an independent set after setting; and n = 3 were used for SEM\/EDS. Results: Data were analyzed at \u03b1 = 0.05 using Kruskal\u2013Wallis tests followed by Bonferroni-adjusted pairwise Mann\u2013Whitney U tests for solubility and eluate pH, and one-way ANOVA was performed followed by Tukey\u2019s post hoc test to assess the microhardness. Solubility differed among groups (p &lt; 0.001) and was higher for the bioceramic sealer than for the resin sealer; pre-setting EDTA exposure increased solubility for the AH Plus Bioceramic Sealer (0.86 \u00b1 0.08% to 1.30 \u00b1 0.16%) and decreased solubility for AH Plus (0.34 \u00b1 0.04% to 0.22 \u00b1 0.03%) (p &lt; 0.05). The eluate pH also differed among groups (p = 0.001) and was higher for the bioceramic sealer (\u224811.7) than for the resin sealer (\u22488.7\u20139.3), with no within-material differences (p = 0.999 and p = 0.851). Microhardness differed among groups (p &lt; 0.001) and was higher for AH Plus (239.70\u2013246.92 HV) than for AH Plus Bioceramic (131.72\u2013170.83 HV); EDTA reduced microhardness only for the bioceramic sealer (p &lt; 0.001), with no significant change for AH Plus (p = 0.475). Descriptive SEM\/EDS findings suggested increased surface irregularities and lower surface Ca for AH Plus Bioceramic after EDTA exposure (12.68 to 7.31 wt%). Conclusions: Pre-setting EDTA contact therefore produced material-dependent changes in early properties and adverse surface-related effects in the calcium silicate-based sealer, supporting thorough chelator removal before obturation.<\/jats:p>","DOI":"10.3390\/dj14040191","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:58:59Z","timestamp":1774357139000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Pre-Setting Exposure to 17% EDTA on Physicochemical and Surface Properties of AH Plus Bioceramic and AH Plus Endodontic Sealers"],"prefix":"10.3390","volume":"14","author":[{"given":"Gerardo","family":"Gomez-Lara","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Luna-Lara","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Oliver-Parra","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suria","family":"Oliver-Rivas","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Luna-Dominguez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Luna-Dominguez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Autonomous University of Tamaulipas, Av. Universidad Esq. con Blvd, Adolfo Lopez Mateos S\/N, Tampico C.P. 89337, Tamaulipas, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref_1","unstructured":"Torabinejad, M., and Walton, R.E. (2009). Endodontics: Principles and Practice, Elsevier Health Sciences. 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