{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:15:30Z","timestamp":1778516130781,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Matrix metalloproteinases (MMP-8 and MMP-9) are key mediators of periodontal tissue degradation and have been proposed as salivary biomarkers of disease activity. However, their comparative responsiveness to non-surgical periodontal therapy remains insufficiently clarified. This study aimed to assess short-term changes in salivary MMP-8 and MMP-9 following full-mouth disinfection (FMD), to evaluate their association with clinical periodontal parameters, and to explore potential differences according to depressive comorbidity. Methods: Eighty patients were included and divided into two groups: 40 patients without depressive disorder (PAR group) and 40 patients with depressive disorder (DEP group). Clinical periodontal parameters (probing depth and clinical attachment loss) and salivary levels of MMP-8 and MMP-9 were assessed at baseline and 12 weeks following FMD. Salivary MMP-8 and MMP-9 levels were determined using the enzyme-linked immunosorbent assay (ELISA). Results: Significant reductions in probing depth and clinical attachment loss were observed following therapy (p &lt; 0.01). Salivary MMP-9 levels decreased significantly in both groups (PAR: 2.4 to 1.1 ng\/mL, p = 0.002; DEP: 2.6 to 1.5 ng\/mL, p = 0.004), whereas MMP-8 did not show statistically significant changes (p &gt; 0.05). Moderate positive correlations were identified between MMP-9 and clinical parameters (r = 0.46\u20130.51), while MMP-8 showed no significant associations. No significant differences in treatment response or biomarker dynamics were observed between groups. Conclusions: The findings indicate a differential salivary biomarker response to periodontal therapy, with MMP-9 showing greater responsiveness than MMP-8 under the conditions of this study. These results suggest a potential role for salivary MMP-9 in reflecting short-term periodontal changes; however, further longitudinal and controlled studies are required to establish its clinical applicability. Depressive comorbidity did not appear to influence short-term outcomes, although this finding should be interpreted cautiously due to the lack of a standardized severity assessment.<\/jats:p>","DOI":"10.3390\/dj14050283","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:32Z","timestamp":1778513972000},"page":"283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Response of Salivary MMP-8 and MMP-9 to Full-Mouth Disinfection: Implications for Biomarker Sensitivity in Periodontal Therapy"],"prefix":"10.3390","volume":"14","author":[{"given":"Bogdan-Constantin","family":"Vasiliu","sequence":"first","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-916X","authenticated-orcid":false,"given":"Ionu\u021b","family":"T\u0103r\u0103boan\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, Clinical Emergency Hospital \u201cSfantul Spiridon\u201d, 700106 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-2368","authenticated-orcid":false,"given":"Alexandra Cornelia","family":"Teodorescu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Lodb\u0103","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2536-7667","authenticated-orcid":false,"given":"Gabriel","family":"Rotundu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecaterina","family":"Anisie","sequence":"additional","affiliation":[{"name":"Department of Microbiology\/Immunology, Clinical Emergency Hospital \u201cSfantul Spiridon\u201d, 700106 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-9672","authenticated-orcid":false,"given":"Ionut","family":"Luchian","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-6910","authenticated-orcid":false,"given":"Sorina Mihaela","family":"Solomon","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: A polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. 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Control"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/5\/283\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:04:34Z","timestamp":1778515474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/5\/283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["dj14050283"],"URL":"https:\/\/doi.org\/10.3390\/dj14050283","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]}}}