{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:45:16Z","timestamp":1791837916716,"version":"4.3.4"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","award":["RESCS-2019-2249-E-UBA-REC"],"award-info":[{"award-number":["RESCS-2019-2249-E-UBA-REC"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]},{"award":["RESCS-2019-2249-E-UBA-REC"],"award-info":[{"award-number":["RESCS-2019-2249-E-UBA-REC"]}],"id":[{"id":"https:\/\/ror.org\/0081fs513","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: In 2018, a classification system for periodontal and peri-implant diseases and conditions defined an endo-periodontal lesion (EPL) as a pathological communication between the endodontic and periodontal tissues of a given tooth. As the evidence to define the etiology, diagnosis, prognosis and treatment was considered limited, a cross-sectional study was carried out to evaluate its prevalence in a population treated at the Periodontics Department of Faculty of Dentistry of University of Buenos Aires (FOUBA). The primary objective was to evaluate the prevalence of EPL. The secondary objective was to identify potential risk indicators associated with their prevalence. Methods: Patients referred for first time to the Periodontics Department of FOUBA during April to June 2025 were consecutively selected. Clinical and radiographic examination was carried out. Categorical outcomes were described using proportions. The crude association between the prevalence of EPL and each of the recorded factors was determined by means of the chi-square test and a logistic regression analysis. Results: A total of 182 participants (128 women and 54 men) with a mean age of 50.8 (standard deviation = 15.6) years were included. The prevalence of participants with EPL was 14.8%. The average was 1.7 teeth per participant with a minimum of 1 tooth and a maximum of 5 teeth. In total, 85.2% of participants with EPL had stage III\u2013IV generalized periodontitis, grade B or C. The logistic regression analysis identified periodontitis stage III\u2013IV (OR = 5.9; 95% Confidence interval [1.9: 18.9] (p = 0.003)) as a potential risk indicator for EPL. Conclusions: The prevalence of participants with EPL in a teaching hospital of the University of Buenos Aires was 14.8%. EPL was more frequently found in participants with periodontitis stage III\u2013IV. Periodontitis stage III\u2013IV was considered a potential risk indicator of EPL.<\/jats:p>","DOI":"10.3390\/dj14060347","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T17:18:16Z","timestamp":1780679896000},"page":"347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Endo-Periodontal Lesions in a Teaching Hospital of the University of Buenos Aires: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0767-8372","authenticated-orcid":false,"given":"Stefania H.","family":"Caceres","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"},{"name":"Periodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7380-2346","authenticated-orcid":false,"given":"Facundo","family":"Caride","sequence":"additional","affiliation":[{"name":"Periodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johana","family":"Castelllanos","sequence":"additional","affiliation":[{"name":"Periodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Bugiolachi","sequence":"additional","affiliation":[{"name":"Periodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Pontarolo","sequence":"additional","affiliation":[{"name":"Periodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagore","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri-Implant Diseases) Research Group, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal and Peri-Implant Diseases) Research Group, Faculty of Dentistry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-6736","authenticated-orcid":false,"given":"Pablo A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Endodontics Department, Faculty of Dentistry, University of Buenos Aires, Buenos Aires C1122, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/jcpe.12935","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions\u2014Introduction and key changes from the 1999 classification","volume":"45","author":"Caton","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1111\/jcpe.12941","article-title":"Acute periodontal lesions (periodontal abscesses and necrotizing periodontal diseases) and endo-periodontal lesions","volume":"45","author":"Herrera","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Aranda Verdu, S., Pallares Sabater, A., Pallares Serrano, A., Rubio Climent, J., and Casino Alegre, A. (2025). Endo-Periodontal Lesions Without Root Damage: Recommendations for Clinical Management. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186655"},{"key":"ref_5","first-page":"134","article-title":"Prevalence of endo-perio lesions according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Disease in a university hospital","volume":"53","author":"Ruetters","year":"2022","journal-title":"Quintessence Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1902\/annals.1999.4.1.84","article-title":"Periodontic-endodontic lesions","volume":"4","author":"Meng","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_7","first-page":"111","article-title":"Assessment of prevalence of Endo-perio lesions among patients of known population: An observational study","volume":"5","author":"Asma","year":"2019","journal-title":"Int. J. Appl. Dent. Sci."},{"key":"ref_8","first-page":"126","article-title":"Prevalence of periodontal disease among dental school patients","volume":"9","author":"Rhee","year":"2014","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Salceanu, M., Melian, A., Dascalu, C., Giuroiu, C., Concita, C., Topoliceanu, C., Melian, D., Frumuzache, A., Solomon, S.M., and M\u00e2r\u0163u, M.-A. (2025). Endo-Periodontal Lesions in Endodontically Treated Teeth with Periapical Pathology. Diagnostics, 15.","DOI":"10.3390\/diagnostics15131663"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1600-051X.1986.tb00852.x","article-title":"Bleeding on probing. A predictor for the progression of periodontal disease?","volume":"13","author":"Lang","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-051X.1975.tb01734.x","article-title":"Periodontal treatment of multirooted teeth. Results after 5 years","volume":"2","author":"Hamp","year":"1975","journal-title":"J. Clin. Periodontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1902\/jop.2001.72.7.963","article-title":"Tooth mobility revisited","volume":"72","author":"Anderegg","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1902\/jop.1958.29.4.272","article-title":"The Infrabony Pocket: Classification and Treatment","volume":"29","author":"Goldman","year":"1958","journal-title":"J. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1600-051X.2004.00555.x","article-title":"Baseline radiographic defect angle of the intrabony defect as a prognostic indicator in regenerative periodontal surgery with enamel matrix derivative","volume":"31","author":"Tsitoura","year":"2004","journal-title":"J. Clin. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1902\/jop.1996.67.7.658","article-title":"Prognosis versus actual outcome. II. The effectiveness of clinical parameters in developing an accurate prognosis","volume":"67","author":"McGuire","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0757.2011.00421.x","article-title":"Development of prognostic indicators using classification and regression trees for survival","volume":"58","author":"Nunn","year":"2012","journal-title":"Periodontol. 2000"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.joen.2023.07.016","article-title":"Diabetes Mellitus Increases the Risk of Apical Periodontitis in Endodontically-Treated Teeth: A Meta-Analysis from 15 Studies","volume":"49","author":"Liu","year":"2023","journal-title":"J. Endod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/00220345251388340","article-title":"Understanding the Periodontitis-Diabetes Linkage: Mechanisms and Evidence","volume":"105","author":"Graves","year":"2026","journal-title":"J. Dent. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.6026\/973206300211144","article-title":"Correlation between endo-perio lesions and systemic diseases: A cross-sectional study","volume":"21","author":"Singh","year":"2025","journal-title":"Bioinformation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.joen.2013.02.006","article-title":"The Relationship of Endodontic\u2013Periodontic Lesions","volume":"39","author":"Simon","year":"2013","journal-title":"J. Endodont."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e20210012","DOI":"10.1590\/1807-2577.01221","article-title":"Epidemiological profile of patients with disabilities undergoing dental treatment under general anesthesia","volume":"50","author":"Lima","year":"2021","journal-title":"Rev. Odontol. UNESP"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Tietmann, C., Tezer, I., Youssef, E., Jepsen, S., and Jepsen, K. (2023). Management of Teeth with Grade 3 Endo-Periodontal Lesions by Combined Endodontic and Regenerative Periodontal Therapy. J. Clin. Med., 13.","DOI":"10.3390\/jcm13010093"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1600-051X.2011.01768.x","article-title":"Periodontal regeneration versus extraction and prosthetic replacement of teeth severely compromised by attachment loss to the apex: 5-year results of an ongoing randomized clinical trial","volume":"38","author":"Cortellini","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/jcpe.13289","article-title":"Periodontal regeneration versus extraction and dental implant or prosthetic replacement of teeth severely compromised by attachment loss to the apex: A randomized controlled clinical trial reporting 10-year outcomes, survival analysis and mean cumulative cost of recurrence","volume":"47","author":"Cortellini","year":"2020","journal-title":"J. Clin. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dommisch, H., Hoedke, D., Dourou, M., Calciolari, E., Herrera, D., and Toma, S. (2026). Management of Periodontal Abscesses and Endodontic-Periodontal Lesions-A Systematic Review. J. Clin. Periodontol., 1\u201326.","DOI":"10.1111\/jcpe.70135"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/6\/347\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:28:31Z","timestamp":1780979311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/6\/347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,5]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["dj14060347"],"URL":"https:\/\/doi.org\/10.3390\/dj14060347","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,5]]}}}