{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:17:13Z","timestamp":1785417433263,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek","award":["FDMZ-2025.2026-04"],"award-info":[{"award-number":["FDMZ-2025.2026-04"]}]},{"award":["FDMZ-2025.2026-04"],"award-info":[{"award-number":["FDMZ-2025.2026-04"]}],"id":[{"id":"https:\/\/ror.org\/05sw4wc49","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Objective: To present a split-mouth bilateral case report comparing a graft-free sinus lift technique developed by C.S. and A.P. using a resorbable magnesium membrane with a standard lateral sinus augmentation using xenograft and collagen membrane. The two approaches were evaluated through clinical, radiographic, and histological outcomes. Methods: A healthy 68-year-old female patient underwent bilateral sinus augmentation in the posterior maxilla. On the right side, a standard sinus lift was performed using a xenogeneic bone graft in combination with a resorbable collagen membrane. On the left side, a graft-free approach was done using only a resorbable magnesium membrane to support the elevated sinus membrane. Results: After a six-month healing period, implants were placed, and bone core biopsies were harvested for histological evaluation. Histological analysis revealed 56.4% newly formed bone in the graft-free magnesium membrane site and 22.5% in the grafted control site. A two-year radiological follow-up confirmed complete bone maturation and implant stability on both sides. Conclusions: This case promotes the potential of a graft-free sinus lift approach using a resorbable magnesium membrane as a promising alternative to conventional grafting protocols. The beneficial clinical, radiological and histological outcomes suggest that this technique may simplify the sinus augmentation procedure and should be further explored in larger clinical studies.<\/jats:p>","DOI":"10.3390\/dj14060381","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:04:04Z","timestamp":1781874244000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Graft-Free Sinus Lift Using a Resorbable Magnesium Membrane vs. Standard Grafting Protocol: A Bilateral Case Report with Histological Evaluation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6393-4438","authenticated-orcid":false,"given":"Cristian","family":"Scognamiglio","sequence":"first","affiliation":[{"name":"Private Practice, Studio Odontoiatrico Dr. Perucchi, Via Luigi Lavizzari 20, 6850 Mendrisio, Switzerland"},{"name":"Latin American Institute of Dental Research and Education\u2014ILAPEO, Curitiba 80710-150, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7617-3431","authenticated-orcid":false,"given":"Alessandro","family":"Perucchi","sequence":"additional","affiliation":[{"name":"Private Practice, Studio Odontoiatrico Dr. Perucchi, Via Luigi Lavizzari 20, 6850 Mendrisio, Switzerland"},{"name":"Latin American Institute of Dental Research and Education\u2014ILAPEO, Curitiba 80710-150, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7157","authenticated-orcid":false,"given":"Marija","family":"\u010candrli\u0107","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka","family":"Peri\u0107 Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology, Embriology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1902\/annals.2003.8.1.328","article-title":"Effect of Maxillary Sinus Augmentation on the Survival of Endosseous Dental Implants. A Systematic Review","volume":"8","author":"Wallace","year":"2003","journal-title":"Ann. Periodontol. Am. Acad. Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Esposito, M., Grusovin, M.G., Rees, J., Karasoulos, D., Felice, P., Alissa, R., Worthington, H.V., and Coulthard, P. (2010). Interventions for Replacing Missing Teeth: Augmentation Procedures of the Maxillary Sinus. Cochrane Database Syst. Rev., CD008397.","DOI":"10.1002\/14651858.CD008397"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jormas.2019.12.021","article-title":"Evaluation of Maxillary Sinus Anatomical Variations and Lesions: A Retrospective Analysis Using Cone Beam Computed Tomography","volume":"121","author":"Amine","year":"2020","journal-title":"J. Stomatol. Oral. Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0011-8532(22)02107-3","article-title":"Maxillary and Sinus Implant Reconstructions","volume":"30","author":"Tatum","year":"1986","journal-title":"Dent. Clin. North Am."},{"key":"ref_5","first-page":"154","article-title":"A New Concept in Maxillary Implant Surgery: The Osteotome Technique","volume":"15","author":"Summers","year":"1994","journal-title":"Compendium"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/prd.12165","article-title":"Sinus Floor Elevation Procedures to Enable Implant Placement and Integration: Techniques, Biological Aspects and Clinical Outcomes","volume":"73","author":"Lundgren","year":"2017","journal-title":"Periodontology 2000"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9144661","DOI":"10.1155\/2023\/9144661","article-title":"15-Year Retrospective Study on the Success Rate of Maxillary Sinus Augmentation and Implants: Influence of Bone Substitute Type, Presurgical Bone Height, and Membrane Perforation during Sinus Lift","volume":"2023","author":"Jamcoski","year":"2023","journal-title":"Biomed. Res. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijom.2010.03.009","article-title":"The Innate Osteogenic Potential of the Maxillary Sinus (Schneiderian) Membrane: An Ectopic Tissue Transplant Model Simulating Sinus Lifting","volume":"39","author":"Srouji","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Milillo, L., Cinone, F., Presti, F.L., Lauritano, D., and Petruzzi, M. (2021). The Role of Blood Clot in Guided Bone Regeneration: Biological Considerations and Clinical Applications with Titanium Foil. Materials, 14.","DOI":"10.3390\/ma14216642"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijom.2021.03.016","article-title":"Non-Grafted versus Grafted Sinus Lift Procedures for Implantation in the Atrophic Maxilla: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"51","author":"Lie","year":"2022","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0501.2011.02340.x","article-title":"A 6-Month Histological Analysis on Maxillary Sinus Augmentation with and without Use of Collagen Membranes over the Osteotomy Window: Randomized Clinical Trial","volume":"24","author":"Barone","year":"2013","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Elad, A., Rider, P., Rogge, S., Witte, F., Tadi\u0107, D., Ka\u010darevi\u0107, \u017d.P., and Steigmann, L. (2023). Application of Biodegradable Magnesium Membrane Shield Technique for Immediate Dentoalveolar Bone Regeneration. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030744"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jma.2021.03.004","article-title":"Magnesium-Based Biomaterials as Emerging Agents for Bone Repair and Regeneration: From Mechanism to Application","volume":"9","author":"Zhou","year":"2021","journal-title":"J. Magnes. Alloys"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1901030","DOI":"10.1002\/adhm.201901030","article-title":"Dual Function of Magnesium in Bone Biomineralization","volume":"8","author":"Zhang","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41368-023-00271-y","article-title":"Magnesium Promotes Vascularization and Osseointegration in Diabetic States","volume":"16","author":"Liu","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e5257","DOI":"10.1590\/1414-431x20165257","article-title":"Effect of Magnesium Ion on Human Osteoblast Activity","volume":"49","author":"He","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.bbrc.2020.07.057","article-title":"Biochemical Activity of Magnesium Ions on Human Osteoblast Migration","volume":"531","author":"Choi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbadis.2004.02.004","article-title":"High Concentrations of Magnesium Modulate Vascular Endothelial Cell Behaviour in Vitro","volume":"1689","author":"Maier","year":"2004","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.3390\/nu5083022","article-title":"Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions","volume":"5","author":"Castiglioni","year":"2013","journal-title":"Nutrients"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Elad, A., Pul, L., Rider, P., Rogge, S., Witte, F., Tadi\u0107, D., Mijiritsky, E., Ka\u010darevi\u0107, \u017d.P., and Steigmann, L. (2023). Resorbable Magnesium Metal Membrane for Sinus Lift Procedures: A Case Series. BMC Oral Health, 23.","DOI":"10.1186\/s12903-023-03695-4"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s12011-020-02183-y","article-title":"Insights into the Role of Magnesium Ions in Affecting Osteogenic Differentiation of Mesenchymal Stem Cells","volume":"199","author":"Qi","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1080\/09205063.2024.2311454","article-title":"The Response of Human Osteoblasts on Bovine Xenografts with and without Hyaluronate Used in Bone Augmentation","volume":"35","author":"Qasim","year":"2024","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Koleilat, A., Mansour, A., Alkassimi, F.M., Aguirre, A., and Almaghrabi, B. (2023). A Combination of Platelet-Rich Fibrin and Collagen Membranes for Sinus Membrane Repair: A Case Report (Repair of Sinus Membrane Perforation). Dent. J., 11.","DOI":"10.3390\/dj11030084"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40729-021-00346-7","article-title":"Management of Schneiderian Membrane Perforations during Maxillary Sinus Floor Augmentation with Lateral Approach in Relation to Subsequent Implant Survival Rates: A Systematic Review and Meta-Analysis","volume":"7","author":"Brinkmann","year":"2021","journal-title":"Int. J. Implant. Dent."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ene, V.-L., Neacsu, I.A., Syafiq Alauddin, M., Ayman, N., Hayei, A., Sabarudin, M.A., Haliza, N., and Baharin, M. (2022). Barrier Membrane in Regenerative Therapy: A Narrative Review. Membranes, 12.","DOI":"10.3390\/membranes12050444"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bla\u0161kovi\u0107, M., Butorac Prpi\u0107, I., Aslan, S., Gabri\u0107, D., Bla\u0161kovi\u0107, D., Cvijanovi\u0107 Peloza, O., \u010candrli\u0107, M., and Peri\u0107 Ka\u010darevi\u0107, \u017d. (2024). Magnesium Membrane Shield Technique for Alveolar Ridge Preservation: Step-by-Step Representative Case Report of Buccal Bone Wall Dehiscence with Clinical and Histological Evaluations. Biomedicines, 12.","DOI":"10.3390\/biomedicines12112537"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/njms.NJMS_38_19","article-title":"Graftless Crestal Hydraulic Sinus Lift with Simultaneous Implant Insertion","volume":"11","author":"Manekar","year":"2020","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Albadani, M.M., Elayah, S.A., Al-Wesabi, M.A., Al-Aroomi, O.A., Al Qadasy, N.E., and Saleh, H. (2024). A Graftless Maxillary Sinus Lifting Approach with Simultaneous Dental Implant Placement: A Prospective Clinical Study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-03949-9"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/07315724.2009.10719764","article-title":"Skeletal and Hormonal Effects of Magnesium Deficiency","volume":"28","author":"Rude","year":"2009","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.actbio.2019.06.001","article-title":"The Role of Magnesium Ions in Bone Regeneration Involves the Canonical Wnt Signaling Pathway","volume":"98","author":"Hung","year":"2019","journal-title":"Acta Biomater."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/6\/381\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:27:55Z","timestamp":1782448075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/6\/381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["dj14060381"],"URL":"https:\/\/doi.org\/10.3390\/dj14060381","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}