{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:01:51Z","timestamp":1785438111070,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["5430"],"award-info":[{"award-number":["5430"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]},{"award":["5430"],"award-info":[{"award-number":["5430"]}],"id":[{"id":"https:\/\/ror.org\/05v75r592","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Objectives: This study aimed to assess and compare the fracture resistance (FR) of teeth with simulated root perforations repaired using NeoMTA 2, NeoPUTTY, and Biodentine. Methods: Sixty-five single-rooted human teeth were decoronated to a standardized length of 13 mm from the apex. Their weight, mesiodistal (MD) and buccolingual (BL) dimensions were recorded for even distribution across five groups (n = 13). The teeth in the three experimental groups were instrumented. Standardized 1 mm perforations were created on the buccal root surface at a fixed 105\u00b0 angle using a precision apparatus. The canals were then obturated with gutta-percha and AH Plus sealer. The perforations were subsequently repaired with NeoMTA 2, NeoPUTTY, or Biodentine. The positive control (PC) group included instrumented and perforated roots, while the negative control (NC) group comprised untreated, intact roots. All control group data used in this study were derived from previously published research. Fracture testing was conducted with a universal testing machine applying a compressive vertical load at 1 mm\/min until fracture occurred. The forces were analyzed using one-way analysis of variance (ANOVA), followed by a post hoc Tukey test. Results: The mean fracture loads were as follows: NC Group: 342.68 \u00b1 146.45 N, PC Group: 212.66 \u00b1 77.89 N, NeoMTA 2 Group: 314.34 \u00b1 131.41 N, NeoPUTTY Group: 243.76 \u00b1 93.71 N, and Biodentine Group: 263.73 \u00b1 94.63 N. No statistically significant differences were observed among experimental groups (p &gt; 0.05). Conclusions: The three biomaterials showed similar strengthening effects but did not fully restore fracture strength.<\/jats:p>","DOI":"10.3390\/dj14070437","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:05:58Z","timestamp":1784077558000},"page":"437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Fracture Resistance in Teeth with Iatrogenic Perforations Repaired Using the Newly Developed Materials NeoPUTTY and NeoMTA 2: An In Vitro Comparative Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Flora","family":"Kakoura","sequence":"first","affiliation":[{"name":"Department of Endodontology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleoniki","family":"Lyroudia","sequence":"additional","affiliation":[{"name":"Department of Endodontology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Economides","sequence":"additional","affiliation":[{"name":"Department of Endodontology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-3243","authenticated-orcid":false,"given":"Georgios","family":"Mikrogeorgis","sequence":"additional","affiliation":[{"name":"Department of Endodontology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-9657.1996.tb00524.x","article-title":"Root Perforations: Classification and Treatment Choices Based on Prognostic Factors","volume":"12","author":"Fuss","year":"1996","journal-title":"Endod. 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