{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:47:15Z","timestamp":1785757635844,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the S\u00e3o Paulo Research Foundation","award":["#2021\/05925-9"],"award-info":[{"award-number":["#2021\/05925-9"]}]},{"name":"the S\u00e3o Paulo Research Foundation","award":["#2014\/11427-8"],"award-info":[{"award-number":["#2014\/11427-8"]}]},{"award":["#2021\/05925-9"],"award-info":[{"award-number":["#2021\/05925-9"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"publisher"}]},{"award":["#2014\/11427-8"],"award-info":[{"award-number":["#2014\/11427-8"]}],"id":[{"id":"https:\/\/ror.org\/02ddkpn78","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. J.","Dentistry Journal"],"abstract":"<jats:p>Objectives: The aim of this study was to evaluate the influence of systemic lutein (LT) supplementation on the progression of experimental periodontitis (EP) and its impact on mechanical periodontal therapy (SRP) in rats. Methods: A total of 120 male Wistar rats were used, and EP was induced by placing a ligature around the left mandibular first molar. The animals were allocated into four groups: NT (no treatment)\/VEH (vehicle), NT\/LT, SRP\/VEH and SRP\/LT. Supplementation was administered daily by oral gavage (0.7 mL\/kg of vehicle or 250 mg\/kg of LT). Animals were euthanized at 7, 15 and 30 days, and the hemimandibles were collected for histomorphometric analysis of the percentage of bone in the furcation region (PBF), histopathological assessment and immunohistochemical detection of inflammatory mediators (tumor necrosis factor-alpha, interleukin-1\u03b2 and interleukin-10) and bone markers (tartrate-resistant acid phosphatase and osteocalcin). Results: Systemic LT supplementation, particularly when associated with scaling and root planning (SRP\/LT), reduced the intensity and extent of the inflammatory infiltrate, partially decreased immunolabelling for IL-1\u03b2 and TNF-\u03b1, and promoted greater organization of the connective tissue. Higher PBF values and fewer TRAP-positive cells were observed in LT-treated groups. Conclusions: Systemic LT supplementation reduced inflammation and alveolar bone resorption and enhanced the effects of mechanical periodontal therapy.<\/jats:p>","DOI":"10.3390\/dj14080466","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:24:07Z","timestamp":1785752647000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Systemic Lutein Supplementation on Periodontal Repair in Experimental Periodontitis in Wistar Rats"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0579-3009","authenticated-orcid":false,"given":"Ot\u00e1vio Augusto Pacheco","family":"Vit\u00f3ria","sequence":"first","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Cristina Noronha","family":"Novaes","sequence":"additional","affiliation":[{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Department of Periodontics, University Center of Santa F\u00e9 do Sul (UNIFUNEC), Santa F\u00e9 do Sul 15775-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-2787","authenticated-orcid":false,"given":"Elisa Mara de Abreu","family":"Furquim","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-5176","authenticated-orcid":false,"given":"Bianca Rafaeli","family":"Piovezan","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-0035","authenticated-orcid":false,"given":"Luiz Guilherme","family":"Fiorin","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-1618","authenticated-orcid":false,"given":"Ruan Henrique Delmonica","family":"Barra","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6220-8024","authenticated-orcid":false,"given":"Gabriela Carrara","family":"Simionato","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Periodontics Division, Department of Diagnostic and Surgery, School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"},{"name":"Nucleus of Study and Research in Periodontics and Implantology (NEPPI), School of Dentistry, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Nucleus of Study and Research in Periodontics and Implantology 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