{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:45:03Z","timestamp":1785930303253,"version":"3.56.0"},"reference-count":90,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. J.","Dentistry Journal"],"abstract":"<jats:p>Background and Objectives: This narrative review aims to evaluate the correlation between dental luting cements, peri-implantitis and the molecular mechanisms governing tissue destruction, with a specific focus on the role of autophagy and nanotechnology. Methods: A comprehensive literature search was conducted across electronic databases, including PubMed, Scopus and Web of Science, to identify relevant studies on cement cytotoxicity, cellular responses and nanomaterial integration. Results: Residual cement in the peri-implant sulcus promotes biofilm accumulation and severe inflammation. At a cellular level, resin-base monomers (e.g., Bis-GMA) impair human gingival fibroblasts via oxidative stress and mitochondrial dysfunction. Autophagy serves as a vital cytoprotective mechanism against cement toxicity and titanium particle accumulation. Experimental studies suggest that incorporating nanomaterials, specifically graphene oxide and silver nanoparticles (\u22641 wt.%), has shown promising results in enhancing antimicrobial efficacy without compromising biocompatibility in vitro. Conclusions: To minimize peri-implantitis, clinical protocols should prioritize the meticulous removal of excess cement and the development of nano-reinforced luting agents. Optimizing these molecular pathways offers actionable preventive strategies, guiding clinicians toward safer cementation protocols and enhanced long-term implant success.<\/jats:p>","DOI":"10.3390\/dj14080485","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:41:42Z","timestamp":1785926502000},"page":"485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dental Luting Cements and Peri-Implantitis: Molecular Mechanisms, Clinical Implications and the Role of Autophagy and Nanotechnology\u2014A Narrative Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Adriana","family":"Bucat\u0103","sequence":"first","affiliation":[{"name":"Pedodontics Department, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 041292 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0329-5102","authenticated-orcid":false,"given":"Lucian Toma","family":"Ciocan","sequence":"additional","affiliation":[{"name":"Discipline of Dental Prosthesis Technology, Faculty of Dentistry, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Dionisie Lupu Street, No. 37, District 2, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4345-282X","authenticated-orcid":false,"given":"Alexandra","family":"Ripszky","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania"},{"name":"The Interdisciplinary Center for Dental Research and Development, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 19-21 Jean Louis Calderon Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"T\u0103nase","sequence":"additional","affiliation":[{"name":"Pedodontics Department, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 041292 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103dulescu","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 37 Dionisie Lupu Street, District 2, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melis","family":"Izet","sequence":"additional","affiliation":[{"name":"The Interdisciplinary Center for Dental Research and Development, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 19-21 Jean Louis Calderon Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6970-1307","authenticated-orcid":false,"given":"Ana","family":"Cernega","sequence":"additional","affiliation":[{"name":"Department of Professional Organization and Medical Legislation-Malpractice, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Mele\u015fcanu","family":"Imre","sequence":"additional","affiliation":[{"name":"Department of Complete Denture, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 17-23 Plevnei Street, 010221 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4047\/jap.2020.12.1.15","article-title":"Attitude and treatment options in implant-supported prosthetics: A survey among a cohort of German dentists","volume":"12","author":"Rauch","year":"2020","journal-title":"J. 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