{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:29:49Z","timestamp":1786768189906,"version":"build-2736575974"},"reference-count":28,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"crossref","award":["24K13275"],"award-info":[{"award-number":["24K13275"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"award":["24K13275"],"award-info":[{"award-number":["24K13275"]}],"id":[{"id":"https:\/\/ror.org\/048rj2z13","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. J.","Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Mastication may influence oral mucosal immunity; however, its association with postprandial salivary secretory immunoglobulin A (s-IgA) dynamics remains unclear. This pilot study examined the association between mean chewing count per bite during rice ball consumption and the postprandial salivary s-IgA response in healthy men. Methods: Thirty-seven healthy adult men were enrolled. Mean chewing count per bite was analyzed continuously and secondarily in exploratory groups defined by the median (&lt;30, n = 18; \u226530 chews\/bite, n = 19). Unstimulated whole saliva was collected before, 0\u20135, 10\u201315, and 25\u201330 min after eating. Salivary s-IgA concentration, saliva weight, and s-IgA secretion rate were evaluated as absolute values and baseline ratios. Baseline-adjusted, repeated-measures, and sensitivity analyses were performed. Results: Mean chewing count per bite correlated positively with normalized salivary s-IgA concentration at 10\u201315 min (\u03c1 = 0.347, p = 0.036) and 25\u201330 min (\u03c1 = 0.352, p = 0.033), but these associations were attenuated after false discovery rate correction (q = 0.053 for both). Baseline salivary s-IgA was inversely associated with normalized responses. In exploratory group comparisons, normalized salivary s-IgA concentration was higher in the \u226530 chews\/bite group at 10\u201315 and 25\u201330 min, whereas absolute s-IgA concentration, saliva weight, and s-IgA secretion rate did not differ between groups. Baseline-adjusted associations were not statistically significant. Conclusions: Higher mean chewing count per bite may be associated with greater relative postprandial salivary s-IgA responses in healthy adult men, but these findings are exploratory and should be interpreted cautiously.<\/jats:p>","DOI":"10.3390\/dj14080519","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:31:09Z","timestamp":1786613469000},"page":"519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Mean Chewing Count per Bite During Rice Ball Consumption and the Postprandial Salivary Secretory Immunoglobulin a Response in Healthy Adult Men: A Pilot Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Koichiro","family":"Tabata","sequence":"first","affiliation":[{"name":"Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komei","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatoshi","family":"Yonenaga","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-5649","authenticated-orcid":false,"given":"Gen","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Sports Dentistry, School of Dentistry, Meikai University, Sakado 350-0283, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Tomofuji","sequence":"additional","affiliation":[{"name":"Department of Community Oral Health, School of Dentistry, Asahi University, Mizuho 501-0296, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","first-page":"30","article-title":"The effects of oral health on systemic health","volume":"65","author":"Kane","year":"2017","journal-title":"Gen. 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