{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:17:37Z","timestamp":1788171457782,"version":"build-2803163510"},"reference-count":22,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Se\u00f1or de Sipan\u2013Vicerrectorado de investigacion"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. J.","Dentistry Journal"],"abstract":"<jats:p>Background: Radiotherapy-induced xerostomia is a prevalent and disabling complication in patients with head and neck cancer, leading to persistent oral pain, impaired salivary function, and substantial deterioration in quality of life. Photobiomodulation (PBM) has emerged as a supportive therapeutic strategy with potential anti-inflammatory, analgesic, and tissue-preserving effects; however, its clinical effectiveness remains incompletely defined. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials evaluating PBM for the management of radiotherapy-induced xerostomia in adults with head and neck cancer. MEDLINE (PubMed), Embase, Scopus, and Web of Science were searched from inception to October 2025. Eligible studies assessed intraoral and\/or extraoral PBM using predefined laser parameters and reported outcomes related to oral pain, salivary flow, or xerostomia-related quality of life. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Random-effects meta-analyses were performed using the Paule\u2013Mandel estimator. Certainty of evidence was appraised using the GRADE framework. Results: Seven randomized trials were included. PBM significantly reduced oral pain compared with control interventions (mean difference [MD] \u22120.76; 95% CI \u22121.33 to \u22120.20), with moderate heterogeneity. For stimulated and unstimulated salivary flow, pooled estimates favored PBM but did not reach statistical significance, and heterogeneity was considerable (I2 &gt; 90%). Substantial variability in laser wavelength, energy density, treatment frequency, anatomical targeting, and radiation exposure of salivary glands contributed to inconsistent effects across studies. The certainty of evidence was rated as moderate for pain reduction and low to very low for salivary flow outcomes. Conclusions: Photobiomodulation provides a clinically meaningful reduction in radiotherapy-related oral pain and may confer symptomatic benefit in xerostomia; however, its effect on salivary flow restoration remains uncertain. Standardized PBM protocols, improved methodological rigor, and adequately powered trials are required to clarify its role in supportive care for head and neck cancer patients.<\/jats:p>","DOI":"10.3390\/dj14090542","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:21:19Z","timestamp":1788168079000},"page":"542","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Photobiomodulation as a Treatment for Xerostomia in Patients with Head and Neck Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Tom\u00e1s Quintero","family":"De La Hoz","sequence":"first","affiliation":[{"name":"Instituto de Postgrado e Investigaci\u00f3n en Ciencias de la Salud, Universidad Laica \u201cEloy Alfaro\u201d de Manab\u00ed, Manta 30202, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-3190","authenticated-orcid":false,"given":"Yaskara Sanjines","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, S\u00e3o Paulo 13414-018, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4350-5428","authenticated-orcid":false,"given":"Fernando Quispe","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Estomatolog\u00eda, Universidad Privada Antenor Orrego, Trujillo 13009, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-3570","authenticated-orcid":false,"given":"Oriana","family":"Rivera-Lozada","sequence":"additional","affiliation":[{"name":"Vicerrectorado de investigaci\u00f3n, Universidad Se\u00f1or de Sip\u00e1n, Chiclayo 14002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshuan J.","family":"Barboza","sequence":"additional","affiliation":[{"name":"Vicerrectorado de investigaci\u00f3n, Universidad Se\u00f1or de Sip\u00e1n, Chiclayo 14002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kim, Y.-J. (2023). Xerostomia and Its Cellular Targets. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065358"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e057","DOI":"10.1590\/1807-3107bor-2025.vol39.057","article-title":"Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: A randomized controlled trial","volume":"39","author":"Savo","year":"2025","journal-title":"Braz. Oral Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1200\/JCO.21.01208","article-title":"Salivary Gland Hypofunction and\/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO\/MASCC\/ASCO Guideline","volume":"39","author":"Mercadante","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.oraloncology.2016.12.031","article-title":"Interventions for the management of radiotherapy-induced xerostomia and hyposalivation: A systematic review and meta-analysis","volume":"66","author":"Mercadante","year":"2017","journal-title":"Oral Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13014-025-02737-1","article-title":"Prevalence of late xerostomia and hyposalivation with associated risk factors in survivors of head and neck cancer after radiotherapy: A multi-centric cross-sectional study","volume":"20","author":"Hassanein","year":"2025","journal-title":"Radiat. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2410421","DOI":"10.1001\/jamanetworkopen.2024.10421","article-title":"Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer: A Multicenter Randomized Clinical Trial","volume":"7","author":"Cohen","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s00784-020-03634-5","article-title":"Saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia: A randomized controlled trial","volume":"25","author":"Marimuthu","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1186\/s40001-024-02167-x","article-title":"Cancer treatment-related xerostomia: Basics, therapeutics, and future perspectives","volume":"29","author":"Hosseini","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0100-39842006000200012","article-title":"Preven\u00e7\u00e3o da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa pot\u00eancia","volume":"39","author":"Lopes","year":"2006","journal-title":"Radiol. Bras."},{"key":"ref_10","first-page":"294","article-title":"Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy","volume":"33","author":"Elias","year":"2012","journal-title":"Spec. Care Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111933","DOI":"10.1016\/j.jphotobiol.2020.111933","article-title":"Effect of photobiomodulation on salivary flow and composition, xerostomia and quality of life of patients during head and neck radiotherapy in short term follow-up: A randomized controlled clinical trial","volume":"209","author":"Louzeiro","year":"2020","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.34172\/jlms.2024.04","article-title":"Evaluation of the effect of photobiomodulation on radiation-induced xerostomia in head and neck cancer patients: A randomized clinical trial","volume":"15","author":"Delavarian","year":"2024","journal-title":"J. Lasers Med. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10103-025-04539-z","article-title":"Combined extraoral and intraoral photobiomodulation for the prevention and management of oral mucositis and Xerostomia caused by the treatment of head and neck cancers","volume":"40","author":"Brunelli","year":"2025","journal-title":"Lasers Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107266","DOI":"10.1016\/j.oraloncology.2025.107266","article-title":"Photobiomodulation for the prevention of oral side effects secondary to head and neck cancer therapy: Results of a randomised, single-blind clinical trial","volume":"164","author":"Camolesi","year":"2025","journal-title":"Oral Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10103-023-03760-y","article-title":"Photobiomodulation for the management of xerostomia and oral mucositis in patients with cancer: A randomized clinical trial","volume":"38","author":"Degasperi","year":"2023","journal-title":"Lasers Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.oooo.2023.11.007","article-title":"Evaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy","volume":"137","author":"Schepanski","year":"2024","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10103-017-2180-3","article-title":"Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy","volume":"32","author":"Palma","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lopez-Garzon, M., Plata-Peregrina, M.D.C., Perez-Sanchez, E.I., Lozano-Lozano, M., Artacho-Cordon, F., and Galiano-Castillo, N. (2025). Photobiomodulation for restoring salivary flow after radiotherapy in head and neck cancer: A randomised placebo-controlled trial. BMC Oral Health, 25.","DOI":"10.1186\/s12903-025-06735-3"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10103-011-1011-1","article-title":"Low-level laser irradiation, cyclooxygenase-2 (COX-2) expression and necrosis of random skin flaps in rats","volume":"27","author":"Masson","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Melo, W.W.P., Arag\u00e3o, W.A.B., Baia-da-Silva, D.C., Nascimento, P.C., Lima, R.R., and de Souza-Rodrigues, R.D. (2022). Effects of Photobiomodulation on Oral Mucositis: Visualization and Analysis of Knowledge. Life, 12.","DOI":"10.3390\/life12111940"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Khalil, M., Hamadah, O., Saifo, M., Khalil, H., Adi, M., Alabeedi, F., and Kujan, O. (2024). Effect of Photobiomodulation on Salivary Cytokines in Head and Neck Cancer Patients with Oral Mucositis: A Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102822"},{"key":"ref_22","first-page":"8671484","article-title":"Efficacy of Tunnel Technique (TUN) versus Coronally Advanced Flap (CAF) in the Management of Multiple Gingival Recession Defects: A Meta-Analysis","volume":"2023","author":"Barboza","year":"2023","journal-title":"Int. J. Dent."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/9\/542\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:44:51Z","timestamp":1788169491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/9\/542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["dj14090542"],"URL":"https:\/\/doi.org\/10.3390\/dj14090542","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}