{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:17:05Z","timestamp":1789042625727,"version":"build-2803163510"},"reference-count":14,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dent. J.","Dentistry Journal"],"abstract":"<jats:p>Background\/Objectives: Toothpastes have recently been developed with purposes ranging from strengthening teeth and restoring periodontal tissue to removing stains and alleviating tooth sensitivity. Although the individual effects of each component are well understood, their interactions with each other remain unclear. Methods: The oral fluoride concentration following the use of dentifrices with different abrasive contents was evaluated in seven healthy adults. In addition, in in vitro apatite pellet experiments, fluoride concentration from the pellets was compared after the use of dentifrices with different abrasive contents. Results: A comparison of fluoride ion concentrations in the oral cavity after using five different types of toothpaste showed that toothpaste without abrasive ingredients retained the highest concentration at all time points from 5 min onward. When the concentration of abrasive ingredients was adjusted in the same toothpaste and compared, the toothpaste with no abrasive (0%) resulted in the highest fluoride concentration compared to all the other toothpastes (10%, 20%, 30%) at 10, 20 and 30 min. The concentration of fluoride released from apatite pellets was also highest in the toothpaste without abrasive ingredients. Conclusions: These results suggest that abrasive ingredients affect the concentration of fluoride in the oral cavity, and the effect may be particularly pronounced in hard tissues such as teeth.<\/jats:p>","DOI":"10.3390\/dj14090584","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:38:39Z","timestamp":1789040319000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Silica-Based Abrasive Ingredients on Fluoride Concentration in Toothpaste: An In Vitro and In Vivo Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Shuma","family":"Hamaguchi","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Akitomo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, Osaka Dental University, Osaka 573-1121, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2225257","DOI":"10.1080\/20002297.2023.2225257","article-title":"Regulatory mechanisms of exopolysaccharide synthesis and biofilm formation in Streptococcus mutans","volume":"15","author":"Zheng","year":"2023","journal-title":"J. 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Res."},{"key":"ref_5","first-page":"CD007868","article-title":"Fluoride toothpastes of different concentrations for preventing dental caries","volume":"3","author":"Walsh","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106376","DOI":"10.1016\/j.archoralbio.2025.106376","article-title":"Effect of adding soluble calcium and pyrophosphate to fluoride toothpaste on enamel remineralization: An in vitro study","volume":"179","author":"Fujiki","year":"2025","journal-title":"Arch. Oral Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Liu, H., and Tu, J. (2021). Reduction of extrinsic tooth stain by a toothpaste containing 10% high cleaning silica, 0.5% sodium phytate and 0.5% sodium pyrophosphate: An 8-week randomised clinical trial. 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J., 12.","DOI":"10.3390\/dj12030064"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105779","DOI":"10.1016\/j.jdent.2025.105779","article-title":"Impact of modifications on the characteristics of salivary pellicle on dental hard tissue: A scoping review","volume":"157","author":"Schestakow","year":"2025","journal-title":"J. Dent."},{"key":"ref_14","first-page":"16","article-title":"Enhancing Intraoral Fluoride Retention in Older Adults: A Randomized Crossover Study","volume":"10","author":"Danciu","year":"2025","journal-title":"JDR Clin. Transl. Res."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/9\/584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:55:41Z","timestamp":1789041341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/14\/9\/584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":14,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["dj14090584"],"URL":"https:\/\/doi.org\/10.3390\/dj14090584","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}