{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:22:10Z","timestamp":1760242930986,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>While the optimal treatment concept of medication-related osteonecrosis of the jaws (MRONJ) is still in debate, several adjunct therapies have been introduced. Among these adjunctive measures, recombinant human parathyroid hormone (rhPTH, teriparatide) seems to be the most promising treatment modality. Several studies have presented the beneficial effect of short-term teriparatide; they have shown an improved level of bone markers and radiographic evidence of bone healing. Although clinical validation by a controlled trial with prospective design would be essential, short-term teripratide therapy would be a good treatment option for MRONJ patients with impaired bone remodeling.<\/jats:p>","DOI":"10.3390\/dj4040041","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T10:09:39Z","timestamp":1478686179000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Role of Teriparatide in Medication-Related Osteonecrosis of the Jaws (MRONJ)"],"prefix":"10.3390","volume":"4","author":[{"given":"Yong-Dae","family":"Kwon","sequence":"first","affiliation":[{"name":"Center for Refractory Jawbone Diseases, Department of Oral &amp; Maxillofacial Surgery, Kyung Hee University Dental Hospital, Seoul 02447, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deog-Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kyung Hee University Hospital, Seoul 02447, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1210\/jcem.86.3.7366","article-title":"Clinical review 123: Anabolic therapy for osteoporosis","volume":"86","author":"Rosen","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.joms.2006.10.076","article-title":"Resolution of bisphosphonate-associated osteonecrosis of the mandible: Possible application for intermittent low-dose parathyroid hormone [rhpth(1-34)]","volume":"65","author":"Harper","year":"2007","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.oraloncology.2010.12.003","article-title":"Geranylgeraniol\u2014A new potential therapeutic approach to bisphosphonate associated osteonecrosis of the jaw","volume":"47","author":"Ziebart","year":"2011","journal-title":"Oral Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the american society for bone and mineral research","volume":"22","author":"Khosla","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00774-009-0128-9","article-title":"Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice","volume":"28","author":"Kobayashi","year":"2010","journal-title":"J. Bone Miner. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00784-010-0507-6","article-title":"The influence of bisphosphonates on viability, migration, and apoptosis of human oral keratinocytes\u2014In vitro study","volume":"16","author":"Pabst","year":"2012","journal-title":"Clin. Oral Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ijom.2012.12.011","article-title":"The effect of bisphosphonate therapy on neutrophil function: A potential biomarker","volume":"42","author":"Favot","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1476-5381.2011.01592.x","article-title":"Zoledronate and pamidronate depress neutrophil functions and survival in mice","volume":"165","author":"Kuiper","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_10","first-page":"690","article-title":"Anabolic actions of parathyroid hormone on bone","volume":"14","author":"Dempster","year":"1993","journal-title":"Endocr. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1359\/JBMR.050309","article-title":"Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters","volume":"20","author":"Arlot","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1001\/archinte.165.15.1762","article-title":"Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass","volume":"165","author":"McClung","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1359\/jbmr.2001.16.10.1846","article-title":"Effects of daily treatment with parathyroid hormone on bone microarchitecture and turnover in patients with osteoporosis: A paired biopsy study","volume":"16","author":"Dempster","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1359\/jbmr.2003.18.1.9","article-title":"The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis","volume":"18","author":"Orwoll","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tem.2015.01.004","article-title":"Anabolic effects of pth and the \u2018anabolic window\u2019","volume":"26","author":"Pazianas","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1210\/jc.2013-4440","article-title":"Two years of denosumab and teriparatide administration in postmenopausal women with osteoporosis (the data extension study): A randomized controlled trial","volume":"99","author":"Leder","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1056\/NEJMoa1005361","article-title":"Teriparatide and osseous regeneration in the oral cavity","volume":"363","author":"Bashutski","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S8756-3282(00)00251-9","article-title":"Parathyroid hormone-related protein analog rs-66271 is an effective therapy for impaired bone healing in rabbits on corticosteroid therapy","volume":"26","author":"Bostrom","year":"2000","journal-title":"Bone"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1600-0501.2007.01342.x","article-title":"The effect of matrix bound parathyroid hormone on bone regeneration","volume":"18","author":"Jung","year":"2007","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1902\/jop.2010.090562","article-title":"Evaluation of parathyroid hormone bound to a synthetic matrix for guided bone regeneration around dental implants: A histomorphometric study in dogs","volume":"81","author":"Valderrama","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tripleo.2010.04.015","article-title":"The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw","volume":"111","author":"Wilde","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1056\/NEJMc1002684","article-title":"Teriparatide therapy for alendronate-associated osteonecrosis of the jaw","volume":"363","author":"Cheung","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00198-014-2622-8","article-title":"Distinctive role of 6-month teriparatide treatment on intractable bisphosphonate-related osteonecrosis of the jaw","volume":"25","author":"Kim","year":"2014","journal-title":"Osteoporos. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s00198-011-1882-9","article-title":"Short-term teriparatide therapy as an adjunctive modality for bisphosphonate-related osteonecrosis of the jaws","volume":"23","author":"Kwon","year":"2012","journal-title":"Osteoporos. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00198-012-1918-9","article-title":"Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw","volume":"24","author":"Narvaez","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3899\/jrheum.081176","article-title":"Resolution of osteonecrosis of the jaw after teriparatide [recombinant human PTH-(1-34)] therapy","volume":"36","author":"Lau","year":"2009","journal-title":"J. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1002\/hed.21380","article-title":"Successful treatment of advanced bisphosphonate-related osteonecrosis of the mandible with adjunctive teriparatide therapy","volume":"33","author":"Lee","year":"2011","journal-title":"Head Neck"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1754-4505.2009.00128.x","article-title":"Bisphosphonate-associated osteonecrosis of the jaw, with healing after teriparatide: A review of the literature and a case report","volume":"30","author":"Narongroeknawin","year":"2010","journal-title":"Spec. Care Dent."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.ijom.2015.07.018","article-title":"Administration of teriparatide improves the symptoms of advanced bisphosphonate-related osteonecrosis of the jaw: Preliminary findings","volume":"44","author":"Kakehashi","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0501.2010.01965.x","article-title":"Retrospective study of two biochemical markers for the risk assessment of oral bisphosphonate-related osteonecrosis of the jaws: Can they be utilized as risk markers?","volume":"22","author":"Kwon","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/hed.23235","article-title":"Factors predicting the prognosis of oral alendronate-related osteonecrosis of the jaws: A 4-year cohort study","volume":"35","author":"Lee","year":"2013","journal-title":"Head Neck"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000313787","article-title":"Bisphosphonates induce apoptosis of circulating endothelial cells in multiple myeloma patients and in subjects with bisphosphonate-induced osteonecrosis of the jaws","volume":"124","author":"Allegra","year":"2010","journal-title":"Acta Haematol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000313684","article-title":"Avascular osteonecrosis of the jaw as a side effect of bisphosphonate treatment","volume":"33","author":"Bamias","year":"2010","journal-title":"Onkologie"},{"key":"ref_35","first-page":"2893","article-title":"Zoledronic acid induces significant and long-lasting modifications of circulating angiogenic factors in cancer patients","volume":"9","author":"Santini","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1200\/JCO.2007.15.5424","article-title":"Osteonecrosis of the jaw related to bevacizumab","volume":"26","author":"Estilo","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bone.2009.07.011","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation?","volume":"45","author":"Lesclous","year":"2009","journal-title":"Bone"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1158\/1078-0432.CCR-10-1614","article-title":"Effect of zoledronate on oral wound healing in rats","volume":"17","author":"Yamashita","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1016\/j.oooo.2013.02.001","article-title":"Osteonecrosis of the mandible associated with bevacizumab therapy","volume":"115","author":"Dias","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin d deficiency: Histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin d in 675 patients","volume":"25","author":"Priemel","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_41","first-page":"547","article-title":"Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly japanese woman with severe osteoporosis","volume":"32","author":"Iwamoto","year":"2012","journal-title":"Clin. Drug Investig."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMra067395","article-title":"Mechanisms of anabolic therapies for osteoporosis","volume":"357","author":"Canalis","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_43","first-page":"407","article-title":"Effects of platelet-derived growth factor, vitamin D and parathyroid hormone on osteoblasts derived from cancer patients on chronic bisphosphonate therapy","volume":"23","author":"Rao","year":"2009","journal-title":"Inte. J. Mol. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1001\/jama.296.24.2927","article-title":"Effects of continuing or stopping alendronate after 5 years of treatment: The fracture intervention trial long-term extension (flex): A randomized trial","volume":"296","author":"Black","year":"2006","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.11005\/jbm.2015.22.4.167","article-title":"Position statement: Drug holiday in osteoporosis treatment with bisphosphonates in south korea","volume":"22","author":"Lee","year":"2015","journal-title":"J. Bone Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00198-008-0604-4","article-title":"Risk of hip fracture after bisphosphonate discontinuation: Implications for a drug holiday","volume":"19","author":"Curtis","year":"2008","journal-title":"Osteoporos. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3899\/jrheum.091022","article-title":"More on the resolution of bisphosphonate-associated osteonecrosis of the jaw","volume":"37","author":"Tsai","year":"2010","journal-title":"J. Rheumatol."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/4\/4\/41\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:35:05Z","timestamp":1760211305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/4\/4\/41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,12]]}},"alternative-id":["dj4040041"],"URL":"https:\/\/doi.org\/10.3390\/dj4040041","relation":{},"ISSN":["2304-6767"],"issn-type":[{"type":"electronic","value":"2304-6767"}],"subject":[],"published":{"date-parts":[[2016,11,9]]}}}